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Article
Open AccessEfficacy of a virtual nursing simulation-based education to provide psychological support for patients affected by infectious disease disasters: a randomized controlled trial
Virtual simulation-based education for healthcare professionals has emerged as a strategy for dealing with infectious disease disasters, particularly when training at clinical sites is restricted due to the ri...
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Article
Open AccessIdentification of exosomal microRNA panel as diagnostic and prognostic biomarker for small cell lung cancer
Small cell lung cancer (SCLC) has an exceptionally poor prognosis; as most of the cases are initially diagnosed as extensive disease with hematogenous metastasis. Therefore, the early diagnosis of SCLC is very...
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Article
Neurofeedback Effect on Symptoms of Posttraumatic Stress Disorder: A Systematic Review and Meta-Analysis
Posttraumatic stress disorder (PTSD) encompasses various psychological symptoms and a high early dropout rate due to treatment unresponsiveness. In recent years, neurofeedback has been implemented to control P...
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Article
Open AccessA machine learning approach to the development and prospective evaluation of a pediatric lung sound classification model
Auscultation, a cost-effective and non-invasive part of physical examination, is essential to diagnose pediatric respiratory disorders. Electronic stethoscopes allow transmission, storage, and analysis of lung...
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Article
The effect of employment status on people with a mental disability and on daily life satisfaction: The mediating effect of acceptance of disability
This study examined the mediating effects of acceptance of disability on the relationship between employment and daily life satisfaction in people with a mental disability. Participants included 160 subjects w...
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Article
Open AccessA simulation-based nursing education of psychological first aid for adolescents exposed to hazardous chemical disasters
Simulation-based education facilitates a learner-centered experience, which has been found to be effective in improving clinical performance, problem-solving ability, and self-confidence in nursing practice. T...
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Article
Open AccessContribution of p53 in sensitivity to EGFR tyrosine kinase inhibitors in non-small cell lung cancer
The emergence of resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) with activating EGFR mutations is a major hindrance to treatment. ...
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Article
Open AccessExosomal miR-1260b derived from non-small cell lung cancer promotes tumor metastasis through the inhibition of HIPK2
Tumor-derived exosomes (TEXs) contain enriched miRNAs, and exosomal miRNAs can affect tumor growth, including cell proliferation, metastasis, and drug resistance through cell-to-cell communication. We investig...
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Article
Association between PD-L1 expression and 18F-FDG uptake in ovarian cancer
Immunotherapy for programmed cell death 1 (PD-1) and its ligand, PD-L1, has been considered an effective treatment for ovarian cancer. 18F-labeled fluoro-2-deoxyglucose positron emission tomography/computed tomog...
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Article
Antioxidant activity and calcium bioaccessibility of Moringa oleifera leaf hydrolysate, as a potential calcium supplement in food
Moringa oleifera leaf (ML) is rich in vitamins and minerals, specially abundant calcium, therefore it is widely used as a calcium supplement for food. This study aimed to investigate the antioxidant activity and ...
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Article
Natural Killer Cells as a Potential Biomarker for Predicting Immunotherapy Efficacy in Patients with Non-Small Cell Lung Cancer
Immunotherapy with immune checkpoint inhibitors for non-small cell lung cancer (NSCLC) has emerged as an important treatment option. Although immunotherapy may significantly improve survival and quality of lif...
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Article
Open AccessAnnual and seasonal patterns in etiologies of pediatric community-acquired pneumonia due to respiratory viruses and Mycoplasma pneumoniae requiring hospitalization in South Korea
Community–acquired pneumonia (CAP) is one of the leading worldwide causes of childhood morbidity and mortality. Its disease burden varies by age and etiology and is time dependent. We aimed to investigate the ...
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Article
Open AccessEpigenetic priming by Dot1l in lymphatic endothelial progenitors ensures normal lymphatic development and function
Proper functioning of the lymphatic system is required for normal immune responses, fluid balance, and lipid reabsorption. Multiple regulatory mechanisms are employed to ensure the correct formation and functi...
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Article
Open AccessEfficacy of glucocorticoids for the treatment of macrolide refractory mycoplasma pneumonia in children: meta-analysis of randomized controlled trials
Mycoplasma pneumoniae is one of the most common pathogens causing community acquired pneumonia in children. Although the rate of macrolide-refractory Mycoplasma pneumoniae (MRMP) has increased, systemic glucocort...
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Article
Open AccessExosomal PD-L1 promotes tumor growth through immune escape in non-small cell lung cancer
Programmed cell death protein-1/programmed cell death ligand-1 (PD-1/PD-L1) pathway blockade is a promising new cancer therapy. Although PD-1/PD-L1 treatment has yielded clinical benefits in several types of c...
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Article
Open AccessEfficacy of the novel CDK7 inhibitor QS1189 in mantle cell lymphoma
Mantle cell lymphoma (MCL) is typically an aggressive and rare form of non-Hodgkin lymphoma (NHL) with a poor prognosis despite recent advances in immunochemotherapy and targeted therapeutics against NHL. New ...
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Article
Open AccessArhalofenate acid inhibits monosodium urate crystal-induced inflammatory responses through activation of AMP-activated protein kinase (AMPK) signaling
Arhalofenate acid, the active acid form of arhalofenate, is a non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand, with uricosuric activity via URAT1 inhibition. Phase II studies revealed d...
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Article
Open AccessCorrection: Corrigendum: Microarray profiling of miRNA and mRNA expression in Rag2 knockout and wild-type mouse spleens
Scientific Data 5:170199 doi: 10.1038/sdata.2017.199 (2018); Published 9 January 2018; Updated 31 July 2018 The Data Descriptor incorrectly states that hybridization for the miRNA expression microarray analysi...
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Article
Discovery of a Potent and Mutant-Selective EGFR Inhibitor that Overcomes T790M-Mediated Resistance in Lung Cancer
Despite remarkable activity in epidermal growth factor receptor (EGFR)-mutant lung cancer patients, the clinical efficacy of EGFR tyrosine kinase inhibitors (TKIs) is limited by the emergence of acquired resis...
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Article
Open AccessComparison of a PCR assay using novel selective primers with current methods in terms of ABO blood phenoty** in rhesus macaques
Nonhuman primates are important animal models in transplantation. To prevent fatal transplantation-induced immune responses, it is necessary to accurately phenotype the monkey ABH antigens, which are the same ...
