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Article
Open AccessA computationally designed ACE2 decoy has broad efficacy against SARS-CoV-2 omicron variants and related viruses in vitro and in vivo
SARS-CoV-2, especially B.1.1.529/omicron and its sublineages, continues to mutate to evade monoclonal antibodies and antibodies elicited by vaccination. Affinity-enhanced soluble ACE2 (sACE2) is an alternative...
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Article
Open AccessCell response analysis in SARS-CoV-2 infected bronchial organoids
The development of an in vitro cell model that can be used to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) research is expected. Here we conducted infection experiments in bronchial organ...
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Article
Open AccessSARS-CoV-2 ORF6 disrupts nucleocytoplasmic trafficking to advance viral replication
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF6 is an antagonist of interferon (IFN)-mediated antiviral signaling, achieved through the prevention of STAT1 nuclear localization. However, the ...
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Article
Open AccessEngineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2
SARS-CoV-2 has mutated during the global pandemic leading to viral adaptation to medications and vaccinations. Here we describe an engineered human virus receptor, ACE2, by mutagenesis and screening for bindin...
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Article
Open AccessCorrection: Corrigendum: Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3
Nature Communications 7: Article number: 10959 (2016); Published: 24 March 2016; Updated: 27 June 2016 In this Article, there is an error in the labelling of the western blot in Fig. 3f. The labels indicating ...
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Open AccessPterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3
Osteoarthritis is a common debilitating joint disorder. Risk factors for osteoarthritis include age, which is associated with thinning of articular cartilage. Here we generate chondrocyte-specific salt-inducib...
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Article
Callicarpa longissima extract, carnosol-rich, potently inhibits melanogenesis in B16F10 melanoma cells
Cosmetic industries focus on develo** materials and resources that regulate skin pigmentation. Melanin, the major pigment in human skin, protects the skin against damage from ultraviolet light. An ethanolic ...
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Is IgA Nephropathy (IgAN) a Familial or Sporadic Disease?
There have been several lines of evidences for familial aggregation of IgA nephropathy (IgAN), as well as mesangial deposition of IgA, suggesting that the susceptibility to this disease is genetically controll...
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Article
Plasma adiponectin levels predict cardiovascular events in the observational Arita Cohort Study in Japan: the importance of the plasma adiponectin levels
As the plasma level of adiponectin is related to metabolic syndrome and cardiovascular events, a low plasma adiponectin level may either cause or trigger cardiovascular disorders. The purpose of this study was...
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Article
Localization of vascular endothelial growth factor in synovial membrane mast cells: examination with ”multi-labelling subtraction immunostaining”
Mast cells are believed to play a novel part in the development of destructive synovial pannus in rheumatoid arthritis (RA). This study was undertaken to investigate the localization of vascular endothelial g...
