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Article
Open AccessExperimental study of sulfate crystallization damage to glutenite rock in the Maijishan Grottoes
Salt crystallization is one of the most important factors causing weathering in grottoes. Cumulative crystallization of salts causes damage such as flaking and peeling of the rocks and accelerates the weatheri...
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Article
Open AccessActivation of CD44 signaling in leader cells induced by tumor-associated macrophages drives collective detachment in luminal breast carcinomas
Collective detachment of cancer cells at the invading front could generate efficient metastatic spread. However, how cancer cell clusters shed from the leading front remains unknown. We previously reported tha...
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Article
Hyaluronan synthase 2 (HAS2) regulates cell phenotype and invadopodia formation in luminal-like breast cancer cells
Although luminal breast cancer cells are typically highly cohesive epithelial cells and have low invasive ability, many eventually develop metastasis. Until now, the underlying mechanisms remain obscure. In th...
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Article
Open AccessCD44/HA signaling mediates acquired resistance to a PI3Kα inhibitor
Most luminal breast carcinomas (BrCas) bearing PIK3CA mutations initially respond to phosphoinositide-3-kinase (PI3K)-α inhibitors, but many eventually become resistant. The underlying mechanisms of this resis...
