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Article
Coordinated action of a gut–liver pathway drives alcohol detoxification and consumption
Alcohol use disorder (AUD) affects millions of people worldwide, causing extensive morbidity and mortality with limited pharmacological treatments. The liver is considered as the principal site for the detoxif...
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Article
Open AccessAcute depletion of BRG1 reveals its primary function as an activator of transcription
The mammalian SWI/SNF-like BAF complexes play critical roles during animal development and pathological conditions. Previous gene deletion studies and characterization of human gene mutations implicate that th...
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Article
Kupffer cell restoration after partial hepatectomy is mainly driven by local cell proliferation in IL-6-dependent autocrine and paracrine manners
Kupffer cells (KCs), which are liver-resident macrophages, originate from the fetal yolk sac and represent one of the largest macrophage populations in the body. However, the current data on the origin of the ...
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Article
Open AccessManganese salts function as potent adjuvants
Aluminum-containing adjuvants have been used for nearly 100 years to enhance immune responses in billions of doses of vaccines. To date, only a few adjuvants have been approved for use in humans, among which a...
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Article
Open AccessManganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy
CD8+ T cell-mediated cancer clearance is often suppressed by the interaction between inhibitory molecules like PD-1 and PD-L1, an interaction acts like brakes to prevent T cell overreaction under normal condition...
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Article
Open AccessNLRP6 self-assembles into a linear molecular platform following LPS binding and ATP stimulation
NOD-like receptors (NLRs) localize in the cytosol to recognize intracellular pathogen products and initialize the innate immune response. However, the ligands and ligand specificity of many NLRs remain unclear...
