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Article
Open AccessIntrinsic signaling pathways modulate targeted protein degradation
Targeted protein degradation is a groundbreaking modality in drug discovery; however, the regulatory mechanisms are still not fully understood. Here, we identify cellular signaling pathways that modulate the t...
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Article
Open AccessDifferences between pathologic and non-pathologic high myopia in 4-year outcomes of anti-VEGF therapy for macular neovascularization
This retrospective observational study aimed to investigate the difference in 4-year outcomes of ranibizumab or aflibercept therapy for macular neovascularization (MNV) with high myopia between pathologic myop...
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Open AccessIn response to “An “outer subarachnoid space”: fact or artifact? A commentary on “Structural characterization of SLYM: a 4th meningeal membrane” fluids and barriers of the CNS (2023) 20:93 by V. Plá et al.”
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Article
Open AccessOff-camera gaze decreases evaluation scores in a simulated online job interview
During the pandemic, digital communication became paramount. Due to the discrepancy between the placement of the camera and the screen in typical smartphones, tablets and laptops, mutual eye contact cannot be ...
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Article
Open AccessBrain-derived neurotrophic factor from microglia regulates neuronal development in the medial prefrontal cortex and its associated social behavior
Microglia and brain-derived neurotrophic factor (BDNF) are essential for the neuroplasticity that characterizes critical developmental periods. The experience-dependent development of social behaviors—associat...
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Open AccessTransient but not chronic hyperglycemia accelerates ocular glymphatic transport
Glymphatic transport is vital for the physiological homeostasis of the retina and optic nerve. Pathological alterations of ocular glymphatic fluid transport and enlarged perivascular spaces have been described...
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Open AccessThe impact of respiratory reactance in oscillometry on survival in patients with idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a poor prognosis. Pulmonary function tests (PFTs) aid in evaluating the disease status of IPF. The clinical significance of oscillometry measur...
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Open AccessStructural characterization of SLYM—a 4th meningeal membrane
Traditionally, the meninges are described as 3 distinct layers, dura, arachnoid and pia. Yet, the classification of the connective meningeal membranes surrounding the brain is based on postmortem macroscopic e...
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Article
Open AccessPleomorphic liposarcoma of the extremity with solitary huge liver metastasis at initial diagnosis treated with conversion surgery combined with adjuvant chemotherapy: a case report
Pleomorphic liposarcoma is the rarest subtype of liposarcoma. Pleomorphic liposarcomas are generally unresponsive to chemotherapy and radiotherapy. Moreover, metastasis in the liver, as the first and sole site...
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Open AccessEffect of grain size on amorphization mechanism and kinetics of bridgmanite in shocked meteorites
Bridgmanite formation and amorphization in shocked meteorites constrain the pressure and temperature conditions during planetary impact. However, the effect of the bridgmanite grain size on its amorphization k...
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Open AccessStapler port position determination using 3-dimensional virtual simulation software in robot-assisted thoracic surgery
In robot-assisted thoracic surgery (RATS) lobectomy using a robotic stapler, stapling is difficult when the stapler port place is close to the resection target vessel. We examined whether three-dimensional com...
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Open AccessLong-term high-fat diet increases glymphatic activity in the hypothalamus in mice
Obesity affects millions of people worldwide and is associated with an increased risk of cognitive decline. The glymphatic system is a brain-wide metabolic waste clearance system, dysfunction of which is linke...
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Article
cIAP1-based degraders induce degradation via branched ubiquitin architectures
Targeted protein degradation through chemical hijacking of E3 ubiquitin ligases is an emerging concept in precision medicine. The ubiquitin code is a critical determinant of the fate of substrates. Although tw...
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Severe leukocytopenia due to copper deficiency induced by zinc supplementation in a patient on peritoneal dialysis: a case report
Zinc deficiency is one cause of anemia. However, it has been reported that some patients who were treated with zinc supplementation to resolve this anemia subsequently experienced copper deficiency, which lead...
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Association between central serous chorioretinopathy susceptibility genes and choroidal parameters
To evaluate the association between central serous chorioretinopathy (CSC) susceptibility genes and choroidal parameters in a large Japanese cohort.
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Open AccessModeling the early stages of Alzheimer’s disease by administering intracerebroventricular injections of human native Aβ oligomers to rats
Alzheimer’s disease (AD) is a progressive and irreversible neurodegenerative disease characterized by the accumulation of aggregated amyloid beta (Aβ) and hyperphosphorylated tau along with a slow decline in c...
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Article
The difficulty of estimating the electron transport rate at photosystem I
It is still a controversial issue how the electron transport reaction is carried out around photosystem I (PSI) in the photosynthetic electron transport chain. The measurable component in PSI is the oxidized P...
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Open AccessTrinity review: integrating Registered Reports with research ethics and funding reviews
One major source of exhaustion for researchers is the redundant paperwork of three different documents—research papers, ethics review applications, and research grant applications—for the same research plan. T...
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Article
Open AccessHuman integrin α10β1-selected mesenchymal stem cells home to cartilage defects in the rabbit knee and assume a chondrocyte-like phenotype
Mesenchymal stem cells (MSCs) have shown promising results in stimulating cartilage repair and in the treatment of osteoarthritis (OA). However, the fate of the MSCs after intra-articular injection and their r...
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Open AccessBrain lipidomics and neurodevelopmental outcomes in intrauterine growth restricted piglets fed dairy or vegetable fat diets
Breast milk has neurodevelopmental advantages compared to infant formula, especially in low-birth-weight infants, which may in part relate to the fat source. This study compared neurodevelopmental outcomes in ...
