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Open AccessIntrinsic signaling pathways modulate targeted protein degradation
Targeted protein degradation is a groundbreaking modality in drug discovery; however, the regulatory mechanisms are still not fully understood. Here, we identify cellular signaling pathways that modulate the t...
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Article
cIAP1-based degraders induce degradation via branched ubiquitin architectures
Targeted protein degradation through chemical hijacking of E3 ubiquitin ligases is an emerging concept in precision medicine. The ubiquitin code is a critical determinant of the fate of substrates. Although tw...
