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Article
Soliton-Based Signaling Communication and Supermolecular Nano-complex by DDMC/PTX in Tumor Microenvironment
Drug delivery systems (DDSs) using DEAE-dextran-MMA graft copolymer (DDMC)/Paclitaxel (PTX) have shown excellent anticancer activity when used as artificial enzymes in a tumor microenvironment (TME). Treatment...
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Article
Soliton Dynamics and DDMC/sncRNAs Complex for Epigenetic Change to Normal Cells in TME
Complex by DDMC/sncRNAs(a-miR-155, piR-30074, and miR-125b) have shown the full recovery of mice from virus-induced sarcoma after treatment by changing to normal cells from cancer cells. With kinetic of inhibi...
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Article
Molecular Identification of Aedes, Armigeres, and Culex Mosquitoes (Diptera: Culicidae) Using Mitochondrial Cytochrome Oxidase Subunit I Genes in Myanmar
Mosquitoes are important vectors that carry disease-causing agents that can affect humans and animals. DNA barcoding is a complementary identification which can be used to validate morphological characterizati...
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Article
Open AccessExpanding diversity of bunyaviruses identified in mosquitoes
Mosquitoes interact with various organisms in the environment, and female mosquitoes in particular serve as vectors that directly transmit a number of microorganisms to humans and animals by blood-sucking. Com...
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Article
Open AccessGlobal research alliance in infectious disease: a collaborative effort to combat infectious diseases through dissemination of portable sequencing
To disseminate the portable sequencer MinION in develo** countries for the main purpose of battling infectious diseases, we found a consortium called Global Research Alliance in Infectious Diseases (GRAID). ...
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Article
Open AccessAn African tick flavivirus forming an independent clade exhibits unique exoribonuclease-resistant RNA structures in the genomic 3′-untranslated region
Tick-borne flaviviruses (TBFVs) infect mammalian hosts through tick bites and can cause various serious illnesses, such as encephalitis and hemorrhagic fevers, both in humans and animals. Despite their importa...
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Article
Serological evidence of Zika virus infection in non-human primates in Zambia
Zika virus (ZIKV) circulation occurs between non-human primates (NHPs) in a sylvatic transmission cycle. To investigate evidence of flavivirus infection in NHPs in Zambia, we performed a plaque reduction neutr...
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Article
Open AccessMolecular detection of Rickettsia felis in dogs, rodents and cat fleas in Zambia
Flea-borne spotted fever is a zoonosis caused by Rickettsia felis, a Gram-negative obligate intracellular bacterium. The disease has a worldwide distribution including western and eastern sub-Saharan Africa where...
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Article
Role of simvastatin in tumor lymphangiogenesis and lymph node metastasis
Lymphangiogenesis plays a crucial role in promoting cancer metastasis to sentinel lymph nodes (LNs) and beyond. Increasing data have shown that simvastatin, a cholesterol-lowering medication for the prevention...
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Article
Open AccessAn innovative diagnostic technology for the codon mutation C580Y in kelch13 of Plasmodium falciparum with MinION nanopore sequencer
The recent spread of artemisinin (ART)-resistant Plasmodium falciparum represents an emerging global threat to public health. In Southeast Asia, the C580Y mutation of kelch13 (k13) is the dominant mutation of ART...
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Article
Open AccessNanopore sequencing of drug-resistance-associated genes in malaria parasites, Plasmodium falciparum
Here, we report the application of a portable sequencer, MinION, for genoty** the malaria parasite Plasmodium falciparum. In the present study, an amplicon mixture of nine representative genes causing resistanc...
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Article
Open AccessA novel diagnostic method for malaria using loop-mediated isothermal amplification (LAMP) and MinION™ nanopore sequencer
A simple and accurate molecular diagnostic method for malaria is urgently needed due to the limitations of conventional microscopic examination. In this study, we demonstrate a new diagnostic procedure for hum...
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Article
Open AccessSeroty** dengue virus with isothermal amplification and a portable sequencer
The recent development of a nanopore-type portable DNA sequencer has changed the way we think about DNA sequencing. We can perform sequencing directly in the field, where we collect the samples. Here, we repor...
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Article
Open AccessGenetic polymorphisms in Plasmodium falciparum chloroquine resistance genes, pfcrt and pfmdr1, in North Sulawesi, Indonesia
Malaria still poses one of the major threats to human health. Development of effective antimalarial drugs has decreased this threat; however, the emergence of drug-resistant Plasmodium falciparum, a cause of Mala...
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Article
Medicinal facilities to B16F10 melanoma cells for distant metastasis control with a supramolecular complex by DEAE-dextran-MMA copolymer/paclitaxel
The resistance of cancer cells to chemotherapeutic drugs (MDR) is a major problem to be solved. A supramolecular DEAE-dextran-MMA copolymer (DDMC)/paclitaxel (PTX) complex was obtained by using PTX as the gues...
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Article
Rapamycin inhibition of CFA-induced lymphangiogenesis in PLN is independent of mast cells
Elucidation of the events responsible for the interaction between lymphatic endothelial cells (LECs) and mast cells (MCs) may prove to be a valuable source for controlling lymphangiogenesis. In the present st...
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Article
Open AccessDengue transmission model by means of viremic adult immuno-competent mouse
Dengue virus infection manifests in three distinct forms in humans: dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. Infection with the virus is a fatal disease; no vaccine is available and p...
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Article
Open AccessFactors associated with skip** breakfast among Inner Mongolia Medical students in China
Few studies on the breakfast consumption habits of medical students in China have been carried out. The aim of the present study was to determine the prevalence of skip** breakfast and factors associated wit...
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Chapter
Dextran Graft Copolymers: Synthesis, Properties and Applications
A graft polymer of methyl methacrylate (MMA) on dextran was prepared using ceric ammonium nitrate (CAN). The properties of these graft copolymers are very interesting because of their amphiphilic microseparate...
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Article
Open AccessPrevalence of and factors associated with daily smoking among Inner Mongolia medical students in China: a cross-sectional questionnaire survey
To date, no study on smoking behavior of medical students in Inner Mongolia has been reported. The aim of the present study was to determine the 1-month prevalence of and factors associated with daily smoking ...
