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  1. Article

    Open Access

    Genome wide screen identifies microsatellite markers associated with acute adverse effects following radiotherapy in cancer patients

    The response of normal tissues in cancer patients undergoing radiotherapy varies, possibly due to genetic differences underlying variation in radiosensitivity.

    Yuichi Michikawa, Tomo Suga, Atsuko Ishikawa, Hideki Hayashi… in BMC Medical Genetics (2010)

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  2. No Access

    Article

    Reliable and Fast Allele-Specific Extension of 3′-LNA Modified Oligonucleotides Covalently Immobilized on a Plastic Base, Combined with Biotin-dUTP Mediated Optical Detection

    In the present work, a convenient microarray SNP ty** system has been developed using a plastic base that covalently immobilizes amino-modified oligonucleotides. Reliable SNP allele discrimination was achiev...

    Yuichi Michikawa, Kentaro Fujimoto, Kenji Kinoshita, Seiko Kawai… in Analytical Sciences (2006)

  3. No Access

    Protocol

    Screening for Aging-Dependent Point Mutations in mtDNA

    Recently, clear evidence has been obtained in our laboratory of a large accumulation of specific point mutations at the same critical control sites for replication in mitochondrial DNA (mtDNA) of human fibrobl...

    Yuichi Michikawa, Giuseppe Attardi in Mitochondrial DNA (2002)

  4. No Access

    Article

    Brief Communication: Role of Nuclear Background and in vivo Environment in Variable Segregation Behavior of the Aging-Dependent T414G Mutation at Critical Control Site for Human Fibroblast mtDNA Replication

    Previous work had shown a large accumulation (up to 50% of mtDNA) of a noninherited T414G transversion at a critical control site for mtDNA replication in skin fibroblasts from the majority of human subjects a...

    Yuichi Michikawa, Kenneth Laderman, Kathleen Richter… in Somatic Cell and Molecular Genetics (1999)