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Article
Synthesis and Characterization of Novel Homopolyimides Containing Pyridine and Morpholine Groups for Gas Separation by Molecular Design and Simulation
A novel 4-(4-(1-morpholinyl)phenyl)-2,6-bis(4-aminophenyl)pyridine (MPAP) diamine monomer was designed and synthesized by introducing non-coplanar morpholine groups and pyridine heterocyclic structures. By one...
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Article
High-performance, water-resistant and ion-conducting gel used as underwater ECG electrodes
High-performance and multifunctional gel materials are valuable in the field of bio-signal monitoring, but their application in underwater environments still faces great challenges. Herein, we have designed a ...
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Article
Low emissivity and thermal insulating infrared stealth composite of silver plating TPU fibers@WPU/CNF aerogel with all-in-one structure
With the development of infrared detection, a single low emissivity or thermal insulation material can no longer meet the needs, and it is particularly important to design a composite material combining these ...
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Article
Application of physiologically based pharmacokinetics modeling in the research of small-molecule targeted anti-cancer drugs
Physiologically based pharmacokinetics (PBPK) models are increasingly used in the drug research and development, especially in anti-cancer drugs. Between 2001 and 2020, a total of 89 small-molecule targeted an...
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Article
Combining temporal and spatial attention for seizure prediction
Approximately 1% of the world population is currently suffering from epilepsy. Successful seizure prediction is necessary for those patients. Influenced by neurons in their own and surrounding locations, the e...
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Article
Open AccessUSP7- and PRMT5-dependent G3BP2 stabilization drives de novo lipogenesis and tumorigenesis of HNSC
GTPase-activating protein-binding protein 2 (G3BP2) is a key stress granule-associated RNA-binding protein responsible for the formation of stress granules (SGs). Hyperactivation of G3BP2 is associated with va...
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Article
Lyocell fiber modified with Schiff base-Cu(II) Reaction and its excellent antimicrobial properties
Lyocell Fiber (LF) with antimicrobial activity is of interest in textile and medical supplies. In this study, a new Schiff base ligand and copper ion (Cu (II)) complex antibacterial Lyocell fiber was prepared....
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Article
Fabrication of gelatin methacryloyl hydrogel microneedles for transdermal delivery of metformin in diabetic rats
Injection therapy for diabetes has poor patient compliance, and the pain occurring at the site of subcutaneous injections causes significant inconvenience to diabetic patients. In this work, to demonstrate the...
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Article
Open AccessMutation spectrum of EXT1 and EXT2 in the Saudi patients with hereditary multiple exostoses
Hereditary Multiple Exostoses (HME), also known as Multiple Osteochondromas (MO) is a rare genetic disorder characterized by multiple benign cartilaginous bone tumors, which are caused by mutations in the gene...
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Article
Noether Theorem on Time Scales for Lagrangian Systems in Event Space
The Noether symmetry and the conserved quantity on time scales in event space are studied in this paper. Firstly, the Lagrangian of parameter forms on time scales in event space are established. The Euler-Lagr...
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Article
Open AccessPhenotype heterogeneity of congenital adrenal hyperplasia due to genetic mosaicism and concomitant nephrogenic diabetes insipidus in a sibling
Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD) is an autosomal recessive disorder caused by mutations in the CYP21A2. Congenital nephrogenic diabetes insipidus (NDI) is a rare X-lin...
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Article
Synthesis, growth mechanism, and photoluminescence property of hierarchical SnO2 nanoflower-rod arrays: an experimental and first principles study
Upstanding SnO2 nanorod arrays covered by hierarchical SnO2 nanoflowers grow on the indium tin oxide (ITO) substrate through a direct hydrothermal method. Corresponding growth mechanism has been investigated alon...
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Article
Open AccessClassical V600E and other non-hotspot BRAF mutations in adult differentiated thyroid cancer
BRAF is the most frequently mutated gene in differentiated thyroid cancer (DTC). Previous studies on DTC have well documented high rates of the BRAF ...
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Article
Mutation prediction by PolyPhen or functional assay, a detailed comparison of CYP27B1 missense mutations
Vitamin D-dependent rickets type 1 (VDDR-I) is caused by mutation in CYP27B1. The glycine residue at codon 102 is not conserved between human (G102) and rodent (S102). G102E mutation results in 80% reduction in i...
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Article
Open AccessMitochondrial lineage M1 traces an early human backflow to Africa
The out of Africa hypothesis has gained generalized consensus. However, many specific questions remain unsettled. To know whether the two M and N macrohaplogroups that colonized Eurasia were already present in...
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Article
High frequency of somatic mitochondrial DNA mutations in human thyroid carcinomas and complex I respiratory defect in thyroid cancer cell lines
Significant progress has been made to elucidate the molecular mechanisms that determine thyroid tumor development and progression. However, most investigations have mainly focused on the genetic alterations of...
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Chapter
Matrix Metalloproteinases in Thyroid Cancer
As compared with tumors from other organs such as lung, colon, and breast, a limited number of studies have been carried out so far on the involvement of MMPs and TIMPs in thyroid tumorigenesis. Based upon the...
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Article
Erratum: Gene therapy of melanoma pulmonary metastasis by intramuscular injection of plasmid DNA encoding tissue inhibitor of metalloproteinases-1
Gene therapy of melanoma pulmonary metastasis by intramuscular injection of plasmid DNA encoding tissue inhibitor of metalloproteinases-1
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Article
Gene therapy of melanoma pulmonary metastasis by intramuscular injection of plasmid DNA encoding tissue inhibitor of metalloproteinases-1
Tumor cell invasion and metastasis are a complex multistep process that involves the degradation of extracellular matrix proteins by matrix metalloproteinases. Tissue inhibitor of metalloproteinase-1 (TIMP-1) ...
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Article
TRAIL-induced apoptosis of thyroid cancer cells: potential for therapeutic intervention
To determine whether the apoptotic machinery of thyroid cancer cells is functional and could be activated for tumoricidal purposes, we examined the apoptosis induced by the cytokines TNF-α, Fas and TRAIL in th...
