-
Article
Open AccessIRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis
Cellular sensitivity to ferroptosis is primarily regulated by mechanisms mediating lipid hydroperoxide detoxification. We show that inositol-requiring enzyme 1 (IRE1α), an endoplasmic reticulum (ER) resident p...
-
Article
Dodging death
Ferroptosis, a cell death mechanism induced by lipid peroxidation, is pivotal in tumor suppression. A recent study shows that tumor repopulating cells evade ferroptosis and develop resistance to therapy via su...
-
Article
Reply to: DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition
-
Article
Open AccessSLC7A11 expression level dictates differential responses to oxidative stress in cancer cells
The cystine transporter solute carrier family 7 member 11 (SLC7A11; also called xCT) protects cancer cells from oxidative stress and is overexpressed in many cancers. Here we report a surprising finding that, ...
-
Article
Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis
SLC7A11-mediated cystine uptake suppresses ferroptosis yet promotes cell death under glucose starvation; the nature of the latter cell death remains unknown. Here we show that aberrant accumulation of intracel...
-
Article
Open AccessA targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers
Targeting ferroptosis, a unique cell death modality triggered by unrestricted lipid peroxidation, in cancer therapy is hindered by our incomplete understanding of ferroptosis mechanisms under specific cancer g...
-
Article
Open AccessFerroptosis, radiotherapy, and combination therapeutic strategies
Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently been revealed to play an im...
-
Article
Author Correction: DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer
-
Article
DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer
Ferroptosis, a form of regulated cell death that is induced by excessive lipid peroxidation, is a key tumour suppression mechanism1–4. Glutathione peroxidase 4 (GPX4)5,6 and ferroptosis suppressor protein 1 (FSP1...
-
Article
Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity
Ferroptosis, a form of regulated cell death triggered by lipid peroxidation, was recently identified as an important mechanism in radiotherapy (RT)-mediated tumor suppression and radioresistance, although the ...
