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  1. No Access

    Article

    CGI1746 targets σ1R to modulate ferroptosis through mitochondria-associated membranes

    Ferroptosis is iron-dependent oxidative cell death. Labile iron and polyunsaturated fatty acid (PUFA)-containing lipids are two critical factors for ferroptosis execution. Many processes regulating iron homeos...

    Zili Zhang, Hong Zhou, Wenjia Gu, Yuehan Wei, Shan Mou… in Nature Chemical Biology (2024)

  2. Article

    Open Access

    Renal histopathological lesions after liver transplantation: What can we find besides calcineurin inhibitor-induced nephrotoxicity?

    Chronic kidney disease (CKD) is a common complication after liver transplantation and is traditionally considered to be secondary to calcineurin inhibitors (CNIs). However, several studies have reported that t...

    Haijiao **, Yuehan Wei, Yongbing Qian, Jiang Zhang, Yao Xu, Hang Zhou… in BMC Nephrology (2022)

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  3. No Access

    Article

    Ubiquitin ligase E3 HUWE1/MULE targets transferrin receptor for degradation and suppresses ferroptosis in acute liver injury

    Hepatic ischemia followed by reperfusion (I/R), a major clinical problem during liver surgical procedures, can induce liver injury with severe cell death including ferroptosis which is characterized by iron-de...

    Yan Wu, Huike Jiao, Yangbo Yue, Kang He, Yuting **… in Cell Death & Differentiation (2022)