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Article
Open AccessPotential impact of blood cholesterol guidelines on statin treatment in the U.S. population using interrupted time series analysis
The 2013 ACC/AHA Guideline was a paradigm shift in lipid management and identified the four statin-benefit groups. Many have studied the guideline’s potential impact, but few have investigated its potential long-...
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Article
Open AccessSUMOylation of annexin A6 retards cell migration and tumor growth by suppressing RHOU/AKT1–involved EMT in hepatocellular carcinoma
The protein annexin A6 (AnxA6) is involved in numerous membrane-related biological processes including cell migration and invasion by interacting with other proteins. The dysfunction of AnxA6, including protei...
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Article
Open AccessAsialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes multi-organ damage, which includes hepatic dysfunction, as observed in over 50% of COVID-19 patients. Angiotensin I converting enzyme (peptid...
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Article
Unique genes carried by abundant species enhance CH4 emissions during the growing season at the Tibetan Plateau
• CH4 emission rates followed an increased pattern during the growing season at Tibetan Plateau.
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Article
Open AccessVOC species controlling O3 formation in ambient air and their sources in Kaifeng, China
The concentration of ozone has been in a rising crescendo in the last decade while the fine particles (PM2.5) is gradually decreasing but still at a high level in central China. Volatile organic compounds (VOCs) ...
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Article
Open AccessDifferential correlation between time in range and eGFR or albuminuria in type 2 diabetes
As a CGM-derived indicator, ‘time in range’ (TIR) is emerging as a key indicator for accurate assessment of glycaemic control. However, there is few report focusing on the correlation of TIR with albumuria and...
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Article
Open AccessA dominant variant in apoptosis-related gene XKR8 is relevant to hereditary auditory neuropathy
Auditory neuropathy is an unusual type of hearing loss. At least 40% of patients with this disease have underlying genetic causes. However, in many hereditary auditory neuropathy cases, etiology remains undete...
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Article
Open AccessDeubiquitinase catalytic activity of MYSM1 is essential in vivo for hematopoiesis and immune cell development
Myb-like SWIRM and MPN domains 1 (MYSM1) is a chromatin binding protein with deubiquitinase (DUB) catalytic activity. Rare MYSM1 mutations in human patients result in an inherited bone marrow failure syndrome,...
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Article
Open AccessRice flowering improves the muscle nutrient, intestinal microbiota diversity, and liver metabolism profiles of tilapia (Oreochromis niloticus) in rice-fish symbiosis
Rice-fish symbiosis, as an ecological and green aquaculture model, is an effective measure to relieve the environmental stress from intensive aquaculture. Compared with traditional aquaculture, the altered rea...
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Article
Open AccessFuel Cell Reactors for the Clean Cogeneration of Electrical Energy and Value-Added Chemicals
Fuel cell reactors can be tailored to simultaneously cogenerate value-added chemicals and electrical energy while releasing negligible CO2 emissions or other pollution; moreover, some of these reactors can even “...
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Article
Open AccessResearch on water meter reading recognition based on deep learning
At present, there are still many old-fashioned water meters in the society, and the water department needs to send staff to read the water meter after arriving at the scene with a handheld all-in-one machine. ...
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Article
Open AccessCTHRC1 targeted by miR-30a-5p regulates cell adhesion, invasion and migration in lung adenocarcinoma
The morbidity of lung cancer ranks first among all cancers. Lung adenocarcinoma (LUAD) is a classification of lung cancer, and cell invasion and migration of LUAD are the main causes for its high mortality. Th...
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Article
Open AccessCaller ID for Risso’s and Pacific White-sided dolphins
Tracking species with expanding ranges is crucial to conservation efforts and some typically temperate marine species are spreading northward into the Arctic Ocean. Risso’s (Gg) and Pacific white-sided (Lo) do...
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Article
Open AccessBiomacromolecules in recent phosphate-shelled brachiopods: identification and characterization of chitin matrix
Phosphate-shelled brachiopods differ in filter-feeding lifestyle, with Lingula anatina an active infaunal burrower, and Discinisca tenuis a shallow marine epibenthic animal. The shells of these animals are built ...
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Article
Spatio-temporal analysis of urban air pollutants throughout China during 2014–2019
Air pollution control has become the top priority of China’s “green development” concept since 2013. The Chinese government has enacted a range of policies and statutes to control contaminant emissions and imp...
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Article
Open AccessExistence of positive solutions for the fractional q-difference boundary value problem
In this paper, we investigate the existence of positive solutions for a class of fractional boundary value problems involving q-difference. By using the fixed point theorem of cone map**s, two existence results...
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Article
Open AccessAn encrusting kleptoparasite-host interaction from the early Cambrian
Parasite–host systems are pervasive in nature but are extremely difficult to convincingly identify in the fossil record. Here we report quantitative evidence of parasitism in the form of a unique, enduring lif...
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Article
Open AccessPositive periodic solutions for high-order differential equations with multiple delays in Banach spaces
This paper deals with the existence of positive ω-periodic solutions for nth-order ordinary differential equation with delays in Banach space E of the form Lnu(t)=f(t,u(t−τ1),…,u(t−τm)),t∈R,$$L_{n}u(t)=f\bigl(t,u...
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Article
Open AccessDifferential DAMP release was observed in the sputum of COPD, asthma and asthma-COPD overlap (ACO) patients
Asthma-COPD overlap (ACO) has been under intensive focus; however, the levels of damage-associated molecular patterns (DAMPs) that can activate the innate and adaptive immune responses of ACO are unknown. The ...
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Article
Open AccessHigher axillary lymph node metastasis burden in breast cancer patients with positive preoperative node biopsy: may not be appropriate to receive sentinel lymph node biopsy in the post-ACOSOG Z0011 trial era
Breast cancer patients with suspicious axillary lymph node (ALN) at ultrasound and positive fine-needle aspiration (FNA) results were required to receive ALN dissection (ALND), which was not certain in the pos...
