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  1. No Access

    Article

    Nanoparticle delivery for central nervous system diseases and its clinical application

    In the treatment of central nervous system (CNS) diseases such as glioma, Alzheimer’s disease (AD) and Parkinson’s disease (PD), drugs are expected to reach specific areas of the brain to achieve the desired e...

    Lin Tang, Rui Zhang, Yusi Wang, Mohan Liu, Die Hu, Yuanda Wang, Li Yang in Nano Research (2024)

  2. No Access

    Article

    Hierarchical multi-agent reinforcement learning for cooperative tasks with sparse rewards in continuous domain

    The sparse reward problem has long been one of the most challenging topics in the application of reinforcement learning (RL), especially in complex multi-agent systems. In this paper, a hierarchical multi-agen...

    **gyu Cao, Lu Dong, **n Yuan, Yuanda Wang in Neural Computing and Applications (2024)

  3. No Access

    Article

    Utilizing diatomaceous earth (DE) as a surface-treating agent of recycled aggregate (RA) for the performance modification of recycled aggregate concrete

    This study proposes the use of diatomaceous earth (DE) as a surface-treating agent for recycled aggregate (RA) to enhance the performance of recycled aggregate concrete (RAC). The treatment process involves pr...

    Hongru Zhang, Mengtao Wan, Yawan Zhao, Yuanda Wang, Bingjian He in Materials and Structures (2023)

  4. No Access

    Article

    Credit assignment in heterogeneous multi-agent reinforcement learning for fully cooperative tasks

    Credit assignment poses a significant challenge in heterogeneous multi-agent reinforcement learning (MARL) when tackling fully cooperative tasks. Existing MARL methods assess the contribution of each agent thr...

    Kun Jiang, Wenzhang Liu, Yuanda Wang, Lu Dong, Changyin Sun in Applied Intelligence (2023)

  5. Article

    Open Access

    Oncolytic adenoviruses expressing checkpoint inhibitors for cancer therapy

    Despite the remarkable success of immune checkpoint inhibitors (ICIs), primary resistance to ICIs causes only subsets of patients to achieve durable responses due to the complex tumor microenvironment (TME). O...

    Daoyuan **e, Yaomei Tian, Die Hu, Yuanda Wang in Signal Transduction and Targeted Therapy (2023)

  6. No Access

    Article

    Multi-objective deep reinforcement learning for crowd-aware robot navigation with dynamic human preference

    The growing development of autonomous systems is driving the application of mobile robots in crowded environments. These scenarios often require robots to satisfy multiple conflicting objectives with different...

    Guangran Cheng, Yuanda Wang, Lu Dong, Wenzhe Cai in Neural Computing and Applications (2023)

  7. Article

    Open Access

    Comparison of the treatment efficacy of umbilical mesenchymal stem cell transplantation via renal subcapsular and parenchymal routes in AKI-CKD mice

    Mesenchymal stem cells (MSCs) have emerged as a promising cell-based therapy for acute kidney injury (AKI). However, the optimal route of MSC transplantation remains controversial, and there have been no compa...

    Mengjie Huang, Duo Li, Jianwen Chen, Yuwei Ji, Tingyu Su in Stem Cell Research & Therapy (2022)

  8. Article

    Open Access

    Rational design of innate defense regulator peptides as tumor vaccine adjuvants

    The development of adjuvants has been an empirical process. Efforts to develop a new design and evaluation system for novel adjuvants are not only desirable but also necessary. Moreover, composite adjuvants th...

    Yaomei Tian, Qiuyue Hu, Rui Zhang, Bailing Zhou, Daoyuan **e, Yuanda Wang in npj Vaccines (2021)

  9. No Access

    Article

    AGL19 directly interacts with floral signal integrator AGL24 in flowering time control of Brassica juncea

    SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 (SOC1) and AGAMOUS-LIKE 24 (AGL24) are pivotal flowering signal integrators, which respectively, belong to TM3/SOC1 and STMADS11 clades of MIKC-type MADS-box family. AGAM...

    Yuanda Wang, Wei Jiang, Yue Dong, **ao Ma, Wenwen Zhou in Acta Physiologiae Plantarum (2020)

  10. No Access

    Chapter and Conference Paper

    Research on Mathematical Model of Mission Effectiveness for Tanker Aircraft

    Using probability method, mathematical model of mission effectiveness for tanker aircraft is established based on operation service condition. It is a feasible model to demonstrate indicators for tanker aircra...

    Zhe Li, Yuanda Wang, Qian Zhang in Proceedings of the First Symposium on Avia… (2014)