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Article
Nanoparticle delivery for central nervous system diseases and its clinical application
In the treatment of central nervous system (CNS) diseases such as glioma, Alzheimer’s disease (AD) and Parkinson’s disease (PD), drugs are expected to reach specific areas of the brain to achieve the desired e...
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Article
Hierarchical multi-agent reinforcement learning for cooperative tasks with sparse rewards in continuous domain
The sparse reward problem has long been one of the most challenging topics in the application of reinforcement learning (RL), especially in complex multi-agent systems. In this paper, a hierarchical multi-agen...
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Article
Utilizing diatomaceous earth (DE) as a surface-treating agent of recycled aggregate (RA) for the performance modification of recycled aggregate concrete
This study proposes the use of diatomaceous earth (DE) as a surface-treating agent for recycled aggregate (RA) to enhance the performance of recycled aggregate concrete (RAC). The treatment process involves pr...
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Article
Credit assignment in heterogeneous multi-agent reinforcement learning for fully cooperative tasks
Credit assignment poses a significant challenge in heterogeneous multi-agent reinforcement learning (MARL) when tackling fully cooperative tasks. Existing MARL methods assess the contribution of each agent thr...
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Article
Open AccessOncolytic adenoviruses expressing checkpoint inhibitors for cancer therapy
Despite the remarkable success of immune checkpoint inhibitors (ICIs), primary resistance to ICIs causes only subsets of patients to achieve durable responses due to the complex tumor microenvironment (TME). O...
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Article
Multi-objective deep reinforcement learning for crowd-aware robot navigation with dynamic human preference
The growing development of autonomous systems is driving the application of mobile robots in crowded environments. These scenarios often require robots to satisfy multiple conflicting objectives with different...
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Article
Open AccessComparison of the treatment efficacy of umbilical mesenchymal stem cell transplantation via renal subcapsular and parenchymal routes in AKI-CKD mice
Mesenchymal stem cells (MSCs) have emerged as a promising cell-based therapy for acute kidney injury (AKI). However, the optimal route of MSC transplantation remains controversial, and there have been no compa...
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Article
Open AccessRational design of innate defense regulator peptides as tumor vaccine adjuvants
The development of adjuvants has been an empirical process. Efforts to develop a new design and evaluation system for novel adjuvants are not only desirable but also necessary. Moreover, composite adjuvants th...
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Article
AGL19 directly interacts with floral signal integrator AGL24 in flowering time control of Brassica juncea
SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 (SOC1) and AGAMOUS-LIKE 24 (AGL24) are pivotal flowering signal integrators, which respectively, belong to TM3/SOC1 and STMADS11 clades of MIKC-type MADS-box family. AGAM...
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Chapter and Conference Paper
Research on Mathematical Model of Mission Effectiveness for Tanker Aircraft
Using probability method, mathematical model of mission effectiveness for tanker aircraft is established based on operation service condition. It is a feasible model to demonstrate indicators for tanker aircra...