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Article
Culture of cerebrospinal fluid-contacting neurons from neonatal mouse spinal cord
Cerebrospinal fluid-contacting neurons (CSF-cNs) act crucial role in chemosensory and mechanosensory function in spinal cord. Recently, CSF-cNs were found to be an immature neuron and may be involved in spinal...
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Article
Hypoplastic modeling of inherent anisotropy in normally and overconsolidated clays
Inherent anisotropy is often observed in natural clays. This paper presents a hypoplastic constitutive model to describe the inherent anisotropy of normally and overconsolidated clays. A stress transformation ...
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Article
Endoscopic resection of gastric low-grade dysplasia with high risk factors is associated with decreased advanced neoplasia: a single-center retrospective cohort study
The natural course of gastric low-grade dysplasia (LGD) remains unclear, and there are inconsistent management recommendations among guidelines and consensus.
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Article
Trilobatin rescues cognitive impairment of Alzheimer’s disease by targeting HMGB1 through mediating SIRT3/SOD2 signaling pathway
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with cognitive impairment that currently is uncurable. Previous study shows that trilobatin (TLB), a naturally occurring food additive, exer...
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Article
Open AccessEndoscopic resections for superficial esophageal squamous cell epithelial neoplasia: focus on histological discrepancies between biopsy and resected specimens
Endoscopic resection has been used for high-grade intraepithelial neoplasia (HGIN) and superficial esophageal squamous cell carcinoma (ESCC) with limited risk of lymph node metastasis. However, some of these l...
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Article
Open AccessLongitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19
Understanding the processes of immune regulation in patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for improving treatment. Here, we performed longitudinal w...
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Article
Open AccessPost-translational modification of Parkin and its research progress in cancer
Clinical practice has shown that Parkin is the major causative gene found in an autosomal recessive juvenile parkinsonism (AR-JP) via Parkin mutations and that the Parkin protein is the core expression product of...
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Chapter
Quantitative Description of Orthotropic Fabric of Sand
Based on the microscopic theory of sand fabric, the novel amplitude parameters describing the spatial arrangement of non-spherical particles is defined, and the verification with the microscopic test for Toyou...
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Chapter
A Novel Description of Plastic Strain Direction
The paper presents a plastic flow equation based on a property-dependent potential theory for geomaterials to describe the flow of sand during loadings involving rotation of principal stress direction. To over...
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Article
Rutaecarpine ameliorates hyperlipidemia and hyperglycemia in fat-fed, streptozotocin-treated rats via regulating the IRS-1/PI3K/Akt and AMPK/ACC2 signaling pathways
We have shown that rutaecarpine extracted from the dried fruit of Chinese herb Evodia rutaecarpa (Juss) Benth (Wu Zhu Yu) promotes glucose consumption and anti-inflammatory cytokine expression in insulin-resistan...
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Article
Gomisin A is a Novel Isoform-Specific Probe for the Selective Sensing of Human Cytochrome P450 3A4 in Liver Microsomes and Living Cells
Nearly half of prescription medicines are metabolized by human cytochrome P450 (CYP) 3A. CYP3A4 and 3A5 are two major isoforms of human CYP3A and share most of the substrate spectrum. A very limited previous s...
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Article
Open AccessFunctional and structural properties of a novel cellulosome-like multienzyme complex: efficient glycoside hydrolysis of water-insoluble 7-xylosyl-10-deacetylpaclitaxel
Cellulosome is a kind of multienzyme complex that displays high activity, selectivity and stability. Here, we report a novel, non-cellulolytic, cellulosome-like multienzyme complex that produced by the Cellulosim...
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Article
Open AccessEstradiol regulates miR-135b and mismatch repair gene expressions via estrogen receptor-β in colorectal cells
Estrogen has anti-colorectal cancer effects which are thought to be mediated by mismatch repair gene (MMR) activity. Estrogen receptor (ER) expression is associated with microRNA (miRNA) expression in ER-posit...
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Article
Characterization of nuciferine metabolism by P450 enzymes and uridine diphosphate glucuronosyltransferases in liver microsomes from humans and animals
To characterize the metabolism of nuciferine by P450 enzymes and uridine diphosphate glucuronosyltransferase (UGT) in liver microsomes from humans and several other animals including rats, mice, dogs, rabbits ...
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Article
Characterization of cardamonin metabolism by P450 in different species via HPLC-ESI-ion trap and UPLC-ESI-quadrupole mass spectrometry
To characterize the metabolism of cardamonin by the P450 enzymes in human and animal liver microsomes.
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Article
Simultaneous Determination of Danshensu and Puerarin in Rat Plasma by LC-MS-MS and Its Application to a Pharmacokinetics and Bioequivalence Study after Oral Administration of Tongmai Drip** Pill and Tongmai Oral Solutions
The active components danshensu (DS) and puerarin (PA) of Tongmai drip** pills (TDP) and oral solution (TOS) were detected in rat plasma after liquid–liquid extraction and oral administration of formulated ...
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Article
Pharmacokinetic behavior of gentiopicroside from decoction of radix gentianae, gentiana macrophylla after oral administration in rats: A pharmacokinetic comaprison with gentiopicroside after oral and intravenous administration alone
The pharmacokinetics in rats of gentiopicroside (GPS) from orally administered decoctions ofRadix Gentianae (DRG) andGentiana macrophlla (DGM) were compared with that of GPS alone administered at 150 mg/kg orally...
