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Article
Identification of Protein–Protein Interaction Associated Functions Based on Gene Ontology
Protein–protein interactions (PPIs) involve the physical or functional contact between two or more proteins. Generally, proteins that can interact with each other always have special relationships. Some previo...
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Article
Tungsten chalcogenides as anodes for potassium-ion batteries
Potassium-ion batteries (PIBs) by virtue of their strong cost competitiveness and similar electrochemical properties to lithium-ion batteries have been deemed to be a promising electrochemical energy storage t...
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Article
Boosting lithium storage of BaFe12O19 by element do** engineering
Ternary metal oxides have been considered a promising anode material for lithium-ion batteries (LIBs) based on their stable chemical compositions and abundant active sites. This work doped Mn into BaFe12O19 by a ...
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Article
Resonant orbit search and stability analysis for elongated asteroids
Periodic orbits are crucial in facilitating the understanding of the dynamical behavior of elongated asteroids. As a specific type of periodic orbit, resonant orbits can enrich the orbit design method of deep-...
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Article
Open AccessArtificial intelligence for diagnosing microvessels of precancerous lesions and superficial esophageal squamous cell carcinomas: a multicenter study
Intrapapillary capillary loop (IPCL) is an important factor for predicting invasion depth of esophageal squamous cell carcinoma (ESCC). The invasion depth is closely related to the selection of treatment strat...
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Article
Screening gene signatures for clinical response subtypes of lung transplantation
Lung is the most important organ in the human respiratory system, whose normal functions are quite essential for human beings. Under certain pathological conditions, the normal lung functions could no longer b...
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Article
Predicting gene phenotype by multi-label multi-class model based on essential functional features
Phenotype is one of the most significant concepts in genetics, which is used to describe all the characteristics of a research object that can be observed. Considering that phenotype reflects the integrated fe...
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Article
Increased S1P induces S1PR2 internalization to blunt the sensitivity of colorectal cancer to 5-fluorouracil via promoting intracellular uracil generation
Sphingosine-1-phosphate (S1P), the backbone of most sphingolipids, activating S1P receptors (S1PRs) and the downstream G protein signaling has been implicated in chemoresistance. In this study we investigated ...
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Article
SphK2 confers 5-fluorouracil resistance to colorectal cancer via upregulating H3K56ac-mediated DPD expression
Aberrant sphingolipid metabolism has been implicated in chemoresistance, but the underlying mechanisms are still poorly understood. Herein we revealed a previously unrecognized mechanism of 5-fluorouracil (5-F...
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Article
Open AccessRisk factors for distal migration of biliary plastic stents and related duodenal injury
The risk factors of duodenal injury from distal migrated biliary plastic stents remain uncertain. The aim of this study was to determine the risk factors of distal migration and its related duodenal injury in ...
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Article
Identification of leukemia stem cell expression signatures through Monte Carlo feature selection strategy and support vector machine
Acute myeloid leukemia (AML) is a type of blood cancer characterized by the rapid growth of immature white blood cells from the bone marrow. Therapy resistance resulting from the persistence of leukemia stem c...
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Article
Inferring novel genes related to oral cancer with a network embedding method and one-class learning algorithms
Oral cancer (OC) is one of the most common cancers threatening human lives. However, OC pathogenesis has yet to be fully uncovered, and thus designing effective treatments remains difficult. Identifying genes ...
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Article
HIV infection alters the human epigenetic landscape
Many complex diseases or traits are the results of both genetic and environmental factors. The environmental factors affect the human body by modifying its epigenetics, which controls the activity of genomes w...
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Article
Identification of the copy number variant biomarkers for breast cancer subtypes
Breast cancer is a common and threatening malignant disease with multiple biological and clinical subtypes. It can be categorized into subtypes of luminal A, luminal B, Her2 positive, and basal-like. Copy numb...
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Article
Discriminating cirRNAs from other lncRNAs using a hierarchical extreme learning machine (H-ELM) algorithm with feature selection
As non-coding RNAs, circular RNAs (cirRNAs) and long non-coding RNAs (lncRNAs) have attracted an increasing amount of attention. They have been confirmed to participate in many biological processes, including ...
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Article
Open AccessIdentification of the core regulators of the HLA I-peptide binding process
During the display of peptide/human leukocyte antigen (HLA) -I complex for further immune recognition, the cleaved and transported antigenic peptides have to bind to HLA-I protein and the binding affinity betw...
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Article
Identification of compound–protein interactions through the analysis of gene ontology, KEGG enrichment for proteins and molecular fragments of compounds
Compound–protein interactions play important roles in every cell via the recognition and regulation of specific functional proteins. The correct identification of compound–protein interactions can lead to a go...
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Article
Open AccessIdentification of novel candidate drivers connecting different dysfunctional levels for lung adenocarcinoma using protein-protein interactions and a shortest path approach
Tumors are formed by the abnormal proliferation of somatic cells with disordered growth regulation under the influence of tumorigenic factors. Recently, the theory of “cancer drivers” connects tumor initiation...
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Article
Identifying novel protein phenotype annotations by hybridizing protein–protein interactions and protein sequence similarities
Studies of protein phenotypes represent a central challenge of modern genetics in the post-genome era because effective and accurate investigation of protein phenotypes is one of the most critical procedures t...
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Article
Open AccessGene expression profiling gut microbiota in different races of humans
The gut microbiome is shaped and modified by the polymorphisms of microorganisms in the intestinal tract. Its composition shows strong individual specificity and may play a crucial role in the human digestive ...
