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  1. No Access

    Article

    Atypical chemokine receptor 3 induces colorectal tumorigenesis in mice by promoting β-arrestin-NOLC1-fibrillarin-dependent rRNA biogenesis

    Atypical chemokine receptor 3 (ACKR3) has emerged as a key player in various biological processes. Its atypical “intercepting receptor” properties have established ACKR3 as the major regulator in the pathophys...

    Juan Yang, Rong-rong Miao, Ya-nan Li, Ting Pan, Shu-hua Wu… in Acta Pharmacologica Sinica (2022)

  2. No Access

    Article

    Targeting NQO1/GPX4-mediated ferroptosis by plumbagin suppresses in vitro and in vivo glioma growth

    Ferroptosis has attracted increasing interest in cancer therapy. Emerging evidences suggest that naturally occurring naphthoquinones exhibit potent anti-glioma effects via various mechanisms.

    Sheng Zhan, Li Lu, Shu-shan Pan, **ao-qian Wei, Rong-rong Miao… in British Journal of Cancer (2022)

  3. No Access

    Article

    SphK2 confers 5-fluorouracil resistance to colorectal cancer via upregulating H3K56ac-mediated DPD expression

    Aberrant sphingolipid metabolism has been implicated in chemoresistance, but the underlying mechanisms are still poorly understood. Herein we revealed a previously unrecognized mechanism of 5-fluorouracil (5-F...

    Yu-Hang Zhang, Wen-Na Shi, Shu-Hua Wu, Rong-Rong Miao, Shi-Yue Sun… in Oncogene (2020)