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Article
Transgenic cucumber fruits that produce elevated level of an anti-aging superoxide dismutase
Superoxide dismutase (SOD) plays an important role in cellular defense against oxidative stress in aerobic organisms. To generate cucumber (Cucumis sativus L.) fruits producing high yields of SOD for an anti-agin...
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Article
BAK7 displays unequal genetic redundancy with BAK1 in brassinosteroid signaling and early senescence in arabidopsis
BRI1-Associated kinase1 (BAK1), a five leucine-rich-repeat containing receptor-like serine/threonine kinase, has been shown to have dual functions: mediating brassinosteroid (BR) signaling and acting in the BR...
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Article
Identification and analysis of cold stress-inducible genes in Korean rapeseed varieties
The rapeseed plant (Brassica napus) is one of the top five oil-producing crops in the world. However, its potential for global cultivation is limited due to its sensitivity to cold. We selected five varieties of ...
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Article
Open AccessCombination treatment with 2-methoxyestradiol overcomes bortezomib resistance of multiple myeloma cells
Bortezomib is a proteasome inhibitor used for the treatment of relapsed/refractory multiple myeloma (MM). However, intrinsic and acquired resistance to bortezomib has already been observed in MM patients. In a...
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Article
The arabidopsis gulliver2/phyB mutant exhibits reduced sensitivity to brassinazole
Brassinosteroids (BRs) are essential plant hormones with roles in normal growth and development. Based on the severe light-independent hypocotyl shortening phenotype of BR mutants, it has been proposed that BR...
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Article
Analysis of anti-BZR1 antibody reveals the roles BES1 in maintaining the BZR1 levels in Arabidopsis
The transcription factor brassinazole-resistant 1 (BZR1) is a key component and positive regulator of the brassinosteroid (BR) signaling pathway. In this study, we report the cloning, expression, and purificat...
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Article
Overexpression of the 3’ half of the PHYB partially suppresses dwarfism in the brassinosteroid-insensitive bri1-5 mutant
Brassinosteroids (BRs) control virtually every aspect of plant growth and development. BRs act alone or in combination with other signals. To identify the signaling components that interact with BRs, we screen...
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Article
Enhanced production of resveratrol derivatives in tobacco plants by improving the metabolic flux of intermediates in the phenylpropanoid pathway
The biosynthesis of flavonoids such as anthocyanin and stilbenes has attracted increasing attention because of their potential health benefits. Anthocyanins and stilbenes share common phenylpropanoid precursor...
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Article
Open AccessGlucocorticoid receptor positively regulates transcription of FNDC5 in the liver
Irisin is secreted by skeletal muscle during exercise and influences energy and metabolic homeostasis. This hormone is a cleaved and secreted fragment of fibronectin type III domain-containing 5 (FNDC5). Eluci...
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Article
Open AccessChebulinic acid inhibits smooth muscle cell migration by suppressing PDGF-Rβ phosphorylation and inhibiting matrix metalloproteinase-2 expression
Excessive migration of vascular smooth muscle cells (VSMCs) after vascular injury contributes to the development of occlusive vascular disease. Inhibition of VSMC migration is a validated therapeutic modality ...
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Article
Plant synthetic GP4 and GP5 proteins from porcine reproductive and respiratory syndrome virus elicit immune responses in pigs
We demonstrated successful overexpression of porcine reproductive and respiratory syndrome virus (PRRSV)-derived GP4D and GP5D antigenic proteins in Arabidopsis. Pigs immunized with transgenic plants expressing G...
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Article
DNA-free mutagenesis of GIGANTEA in Brassica oleracea var. capitata using CRISPR/Cas9 ribonucleoprotein complexes
The CRISPR–Cas9 system is a powerful tool for editing genes of interest in specific plant genomes. Indeed, genome-editing systems have been used to enhance a variety of agricultural traits and to study gene fu...
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Article
Open AccessInduced extracellular production of stilbenes in grapevine cell culture medium by elicitation with methyl jasmonate and stevioside
We report the high production of stilbenes, including resveratrol and viniferin, in grapevine (Vitis labruscana L.) cell cultures through elicitation with methyl jasmonate (MeJA) and stevioside (STE). Methyl-β-cy...
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Article
Pharmacological inhibition of androgen receptor expression induces cell death in prostate cancer cells
The androgen receptor (AR) plays an important role in the pathogenesis and development of prostate cancer (PCa). Mostly, PCa progresses to androgen-independent PCa, which has activated AR signaling from androg...
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Article
Putative E3 ligases as candidates controlling BRASSINOSTEROID INSENSITIVE 2 (BIN2) kinase in Arabidopsis
The Glycogen synthase kinase 3 (GSK3)-like kinase BRASSINOSTEROID-INSENSITIVE2 (BIN2), a major negative regulator in the Brassinosteroids (BRs) signaling, is involved in a variety of plant signaling pathways b...
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Article
Characterization of BRASSINOSTEROID F-BOX Proteins BRFPs that Regulate BRASSINOSTEROID-INSENSITIVE 2 Kinase
BRASSINOSTEROIDS (BRs) play important roles in regulating plant growth and development. The Arabidopsis GSK3-like kinase BIN2, a major negative regulator of BR signaling, plays diverse roles in plant growth an...
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Article
Overexpression of R2R3-MYB IbMYB1a induces anthocyanin pigmentation in soybean cotyledon
This is the first report showing anthocyanin accumulation in the soybean cotyledon via genetic transformation of a single gene.
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Article
Open AccessSoybean flower-specific R2R3-MYB transcription factor gene GmMYB108 induces anthocyanin production in Arabidopsis thaliana
R2R3-MYB transcription factors (TFs) are known to play a key role in regulating the expression of structural genes involved in plant flavonoid biosynthesis. However, the regulatory networks and related genes c...
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Article
Optimization of CRISPR/Cas9 ribonucleoprotein delivery into cabbage protoplasts for efficient DNA-free gene editing
The CRISPR/Cas9-based gene editing system for the direct delivery of pre-assembled Cas9 ribonucleoproteins (RNPs), consisting of a Cas9 nuclease and a single guide RNA (sgRNA), into plant protoplasts enables D...
