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Open AccessThe association of arterial partial oxygen pressure with mortality in critically ill sepsis patients: a nationwide observational cohort study
Although several trials were conducted to optimize the oxygenation range in intensive care unit (ICU) patients, no studies have yet reached a universal recommendation on the optimal a partial pressure of oxyge...
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Open AccessPrognosis of mechanically ventilated patients with COVID-19 after failure of high-flow nasal cannula: a retrospective cohort study
There is an argument whether the delayed intubation aggravate the respiratory failure in Acute respiratory distress syndrome (ARDS) patients with coronavirus disease 2019 (COVID-19). We aimed to investigate th...
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Open AccessPrognostic evaluation of quick sequential organ failure assessment score in ICU patients with sepsis across different income settings
There is conflicting evidence on association between quick sequential organ failure assessment (qSOFA) and sepsis mortality in ICU patients. The primary aim of this study was to determine the association betwe...
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Open AccessImpact of a cumulative positive fluid balance during the first three ICU days in patients with sepsis: a propensity score-matched cohort study
The optimal strategy for fluid management during the first few days of ICU in sepsis patients remains controversial. We aimed to investigate the impact of cumulative fluid balance during the first three days o...
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Open AccessA targeted metabolomics approach for sepsis-induced ARDS and its subphenotypes
Acute respiratory distress syndrome (ARDS) is etiologically and clinically a heterogeneous disease. Its diagnostic characteristics and subtype classification, and the application of these features to treatment...
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Article
Open AccessMortality of patients with hospital-onset sepsis in hospitals with all-day and non-all-day rapid response teams: a prospective nationwide multicenter cohort study
Hospital-onset sepsis is associated with a higher in-hospital mortality rate than community-onset sepsis. Many hospitals have implemented rapid response teams (RRTs) for early detection and timely management o...
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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
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Article
Open AccessThe story of critical care in Asia: a narrative review
Asia has more critically ill people than any other part of our planet. The aim of this article is to review the development of critical care as a specialty, critical care societies and education and research, ...
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Article
Open AccessExpert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method
Coronavirus disease 2019 (COVID-19) pandemic has caused unprecedented pressure on healthcare system globally. Lack of high-quality evidence on the respiratory management of COVID-19-related acute respiratory f...
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Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19)
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, Coronavirus Disease 2019 (COVID-19), affecting thousands of people around the world. Urgent ...
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Effect of adjunctive corticosteroid on 28-day mortality in neutropenic patients with septic shock
The role of adjunctive corticosteroid in septic shock remains debatable, and its role has not been assessed in neutropenic patients. We evaluated whether hydrocortisone reduces 28-day mortality in neutropenic ...
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Open AccessSerum developmental endothelial locus-1 is associated with severity of sepsis in animals and humans
Disruption of the endothelial glycocalyx has a prominent role in the pathophysiology of sepsis. Developmental endothelial locus-1 (Del-1) is an endothelial-derived anti-inflammatory factor. We hypothesized tha...
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Open AccessResponse to the letter to the Editor “Comparing video and direct laryngoscopy for tracheal intubation in the general ward” by Shao and Colleagues
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Open AccessVideo laryngoscopy versus direct laryngoscopy for first-attempt tracheal intubation in the general ward
Recent trials showed that video laryngoscopy (VL) did not yield higher first-attempt tracheal intubation success rate than direct laryngoscopy (DL) and was associated with higher rates of complications. Trache...
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Severe hypercapnia and outcome of mechanically ventilated patients with moderate or severe acute respiratory distress syndrome
To analyze the relationship between hypercapnia develo** within the first 48 h after the start of mechanical ventilation and outcome in patients with acute respiratory distress syndrome (ARDS).
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Erratum to: Withholding and withdrawal of life-sustaining treatments in low-middle-income versus high-income Asian countries and regions
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Withholding and withdrawal of life-sustaining treatments in low-middle-income versus high-income Asian countries and regions
To compare the attitudes of physicians towards withholding and withdrawing life-sustaining treatments in intensive care units (ICUs) in low-middle-income Asian countries and regions with those in high-income o...
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Article
Open AccessManagement and outcome of mechanically ventilated patients after cardiac arrest
The aim of this study was to describe and compare the changes in ventilator management and complications over time, as well as variables associated with 28-day hospital mortality in patients receiving mechanic...
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Impact of sedation and analgesia during noninvasive positive pressure ventilation on outcome: a marginal structural model causal analysis
There are limited data available about the role of sedation and analgesia during noninvasive positive pressure ventilation (NPPV). The objective of study was to estimate the effect of analgesic or sedative dru...
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Article
Failure of high-flow nasal cannula therapy may delay intubation and increase mortality
Intubation in patients with respiratory failure can be avoided by high-flow nasal cannula (HFNC) use. However, it is unclear whether waiting until HFNC fails, which would delay intubation, has adverse effects....
