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Article
Multiparty sharing of quantum images based on product state of maximally entangled GHZ state
To share images securely in the network, this paper proposes a multiparty sharing of quantum images scheme based on the basic theory of quantum state sharing. According to the number of qubits within the share...
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Article
Open AccessHigh-throughput and targeted drug screens identify pharmacological candidates against MiT-translocation renal cell carcinoma
MiT-Renal Cell Carcinoma (RCC) is characterized by genomic translocations involving microphthalmia-associated transcription factor (MiT) family members TFE3, TFEB, or MITF. MiT-RCC represents a specific subtype o...
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Article
Open AccessFumarate hydratase-deficient renal cell carcinoma cells respond to asparagine by activation of the unfolded protein response and stimulation of the hexosamine biosynthetic pathway
The loss-of-function mutation of fumarate hydratase (FH) is a driver of hereditary leiomyomatosis and renal cell carcinoma (HLRCC). Fumarate accumulation results in activation of stress-related mechanisms lead...
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Article
BTBD9 and dopaminergic dysfunction in the pathogenesis of restless legs syndrome
Restless legs syndrome (RLS) is characterized by an urge to move legs, usually accompanied by uncomfortable sensations. RLS symptoms generally happen at night and can be relieved by movements. Genetic studies ...
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Article
Open AccessProteasome inhibition disrupts the metabolism of fumarate hydratase- deficient tumors by downregulating p62 and c-Myc
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is characterized by germline mutations of the FH gene that encodes for the TCA cycle enzyme, fumarate hydratase. HLRCC patients are at risk for the devel...
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Article
Open AccessPreclinical efficacy of dual mTORC1/2 inhibitor AZD8055 in renal cell carcinoma harboring a TFE3 gene fusion
Renal cell carcinomas (RCC) harboring a TFE3 gene fusion (TfRCC) represent an aggressive subset of kidney tumors. Key signaling pathways of TfRCC are unknown and preclinical in vivo data are lacking. We investiga...
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Article
Open AccessS100A4 promotes pancreatic cancer progression through a dual signaling pathway mediated by Src and focal adhesion kinase
S100A4 expression is associated with poor clinical outcomes of patients with pancreatic cancer. The effects of loss or gain of S100A4 were examined in pancreatic cancer cell lines. S100A4 downregulation remark...
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Article
Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers
Recent large-scale next-generation genetic analyses underscore the frequent occurrence and importance of gene fusion events—including those involving the MiT t...
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Article
Reductive carboxylation supports growth in tumour cells with defective mitochondria
Tumour cells with defective mitochondria are found to use glutamine-dependent reductive carboxylation, rather than oxidative metabolism, as the major pathway of citrate and lipid formation.
