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Article
Open AccessInduction of CYP3A activity by dexamethasone may not be strong, even at high doses: insights from a case of tacrolimus co-administration
Dexamethasone (DEX) induces CYP3A activity in a concentration-dependent manner. However, no study has examined changes in the blood concentration of CYP3A substrate drugs when DEX is administered at high doses...
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Chapter and Conference Paper
Sparse Direct Convolutional Neural Network
We propose a new computation and memory efficient algorithm to speed up Convolutional Neural Networks (CNNs). Equipped with several millions of parameters, leveraging large datasets, CNNs have achieved state-o...
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Article
Persistent drug interaction between aprepitant and warfarin in patients receiving anticancer chemotherapy
Case We describe two cases in which treatment with aprepitant persistently altered antithrombotic control in patients receiving warfarin. A 60-year-old man received 5 weekly cycles of chemotherap...
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Article
A Proposal for a Pharmacokinetic Interaction Significance Classification System (PISCS) Based on Predicted Drug Exposure Changes and Its Potential Application to Alert Classifications in Product Labelling
Pharmacokinetic drug-drug interactions (DDIs) are one of the major causes of adverse events in pharmacotherapy, and systematic prediction of the clinical relevance of DDIs is an issue of significant clinical i...
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Article
General Framework for the Prediction of Oral Drug Interactions Caused by CYP3A4 Induction from In Vivo Information
Background: Induction of cytochrome P450 (CYP) 3A4 potentially reduces the blood concentrations of substrate drugs to less than one-tenth, which results in ineffective pharmacotherapy. Although t...
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Article
General Framework for the Quantitative Prediction of CYP3A4-Mediated Oral Drug Interactions Based on the AUC Increase by Coadministration of Standard Drugs
Cytochrome P450 (CYP) 3A4 is the most prevalent metabolising enzyme in the human liver and is also a target for various drug interactions of significant clinical concern. Even though there are numerous reports...
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Article
Treatment of osteochondral fracture of the trochlea of the PIP joint
Introduction: Osteochondral (OC) fractures of the trochlea of the PIP joint are rare but the treatment of these fractures can be challenging [2, 5, 6, 10]. And the therapeutic guideline i...
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Article
Nutritional factors and risk of pancreatic cancer: a population-based case-control study based on direct interview in Japan
Few epidemiologic studies have examined the role of nutrient intake in the development of pancreatic cancer in Japan. We addressed this association in a population-based case-control study.
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Article
Menstrual and reproductive factors and the mortality risk of gastric cancer in Japanese menopausal females
Objective: The relationship between gastric cancer and menstrual and reproductive history was investigated for 40,535 postmenopausal females from a large-scale prospective cohort in Japan (JACC: Japan Collaborat...
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Article
A prospective cohort study of cigarette smoking and pancreatic cancer in Japan
Objective: To examine the association of cigarette smoking with the risk of death from pancreatic cancer in a prospective cohort study. Methods: A total of 110,792 inhabitants, aged 40–79 years (46,465 men and 6...
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Article
Nationwide epidemiological survey of chronic pancreatitis in Japan
The aim of this study was to estimate the number of patients treated for chronic pancreatitis in 1994 in Japan and to explore the clinico-epidemiological features of chronic pancreatitis. Two surveys were con...
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Article
A study on how a 6-month aerobic exercise program can modify coronary risk factors depending on their severity in middle-aged sedentary women
It is well known that physical exercise can reduce coronary risk factors. But how an aerobic exercise modifies coronary risk factors in relation to severity and physical fitness is still controversial.
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Article
A case-control study on risk factors for scleroderma
We conducted a case-control study to evaluate the contribution of some risk factors to the development of scleroderma. Fifty-seven patients with scleroderma (seven males and 50 females) were interviewed with a...
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Article
Case-control study of oral cancer in Shenyang, Northeastern China
To investigate the risk factors of oral cancer, a hospital-based case-control study was conducted from March 1989 to September 1995 in Shenyang, Liaoning Province, China.
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Article
Abustracts from Japanese journal of hygiene (Nihon Eiseigaku Zasshi) vol.52 no.4
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Article
Report on the nationwide epidemiological survey of exudative age-related macular degeneration in Japan
The research Committee on Chorioretinal Degeneration, incooperation with the Research Committee on theEpidemiology of Intractable Diseases, performed the secondnationwide epidemiological survey of exudative ag...
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Article
Subsite-specific risk factors for colorectal cancer: a hospital-based case-control study in Japan
To investigate the subsite-specific risk factors for colorectal cancer, we conducted a case-control study, using a common questionnaire which inquired about general lifestyles over the past five years (1988–92...
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Article
Relationship between chlordane and its metabolites in blood of pest control operators and spraying conditions
Chlordane has been widely used to protect soil and house foundations against termite infestation. Pest control operators (PCOs) are occupationally exposed to chlordane. The relationship between chlordane and i...
