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A case-control study on risk factors for scleroderma

  • Original Article
  • Published:
Japanese Journal of Rheumatology

Abstract

We conducted a case-control study to evaluate the contribution of some risk factors to the development of scleroderma. Fifty-seven patients with scleroderma (seven males and 50 females) were interviewed with a structured questionnaire at Saga Medical School Hospital from 1993 to 1995. Fifty-seven controls, who were individually sex and age matched with each case, were also interviewed with the same questionnaire during the same period. Eight individuals of parents or siblings of the scleroderma patients had Raynaud’s phenomenon, as compared to none of the controls (P<0.01). Four siblings of the cases had been affected by autoimmune connective tissue diseases, as compared to none of the controls (P<0.05). The percentage of the cases who had experience in the work exposed to hand-arm stress or vibration was larger than that of the controls (P<0.05). These findings may reflect familial or environmental factors operating in the development of scleroderma.

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Authors and Affiliations

  1. Department of Community Health Science, Saga Medical School, 5-1-1, Nabeshima, 849-0937, Saga, Japan

    Mitsuru Mori

  2. Department of Clinical Nursing, Saga Medical School, 5-1-1, Nabeshima, 849-0937, Saga, Japan

    Akihide Ohta

  3. Department of Internal Medicine, Saga Medical School, 5-1-1, Nabeshima, 849-0937, Saga, Japan

    Noriaki Suzuki, Osamu Ushiyama & Kohei Nagasawa

  4. Department of General Medicine, Saga Medical School, 5-1-1, Nabeshima, 849-0937, Saga, Japan

    Kojiro Yoshihara, Seiji Yamashiro, Hiroshi Kohno, Sumiko Kanegae & Shunzo Koizumi

  5. Department of Preventive Medicine, Nagoya University School of Medicine, Tsurumai-cho 65, Showa-ku, 466, Nagoya, Japan

    Yoshiyuki Ohno

Authors
  1. Mitsuru Mori
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  2. Akihide Ohta
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  4. Osamu Ushiyama
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  5. Kohei Nagasawa
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  6. Kojiro Yoshihara
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  7. Seiji Yamashiro
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  8. Hiroshi Kohno
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  9. Sumiko Kanegae
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  10. Shunzo Koizumi
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  11. Yoshiyuki Ohno
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Cite this article

Mori, M., Ohta, A., Suzuki, N. et al. A case-control study on risk factors for scleroderma. Japanese Journal of Rheumatology 8, 239–248 (1998). https://doi.org/10.1007/BF03041245

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  • DOI: https://doi.org/10.1007/BF03041245

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