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  1. Article

    Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound

    Prophylactic vaccination of rhesus macaques with rhesus cytomegalovirus (RhCMV) vectors expressing simian immunodeficiency virus (SIV) antigens (RhCMV/SIV) elicits immune responses that stringently control hig...

    Afam A. Okoye, Scott G. Hansen, Mukta Vaidya, Yoshinori Fukazawa… in Nature Medicine (2018)

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    B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers

    Fukazawa et al. report that SIV persists in follicular helper T cells in elite controller macaques, evading clearance by CD8+ T cells

    Yoshinori Fukazawa, Richard Lum, Afam A Okoye, Haesun Park… in Nature Medicine (2015)

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    Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines

    Live attenuated SIV vaccines protect nonhuman primates from infection with pathogenic wild-type SIV, but the crucial mechanisms have not been clear. In this issue, Louis Picker and colleagues show that protect...

    Yoshinori Fukazawa, Haesun Park, Mark J Cameron, Francois Lefebvre… in Nature Medicine (2012)