32 Result(s)

Article

Close interaction with bone marrow mesenchymal stromal cells induces the development of cancer stem cell-like immunophenotype in B cell precursor acute lymphoblastic leukemia cells

Minimal residual disease of leukemia may reside in the bone marrow (BM) microenvironment and escape the effects of chemotherapeutic agents. This study investigated interactions between B cell precursor (BCP)-a...

Kentaro Kihira, Vipin Shankar Chelakkot… in International Journal of Hematology (2020)

Article

Acute and late toxicities of pirarubicin in the treatment of childhood acute lymphoblastic leukemia: results from a clinical trial by the Japan Association of Childhood Leukemia Study

Anthracyclines are used to treat childhood acute lymphoblastic leukemia (ALL). Even when administered at low doses, these agents are reported to cause progressive cardiac dysfunction. We conducted a clinical t...

Hiroki Hori, Tooru Kudoh… in International Journal of Clinical Oncology (2017)

Article

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity

Jun Yang and colleagues perform targeted sequencing of NUDT15 and identify loss-of-function variants associated with thiopurine intolerance. Functionally, they show that NUDT15 inactivates thiopurine metabolites,...

Takaya Moriyama, Rina Nishii, Virginia Perez-Andreu, Wenjian Yang… in Nature Genetics (2016)

Reference Work Entry In depth

Biomarkers of Graft-Versus-Host Disease

Acute and chronic graft-versus-host disease (GVHD) remains a significant cause of morbidity and mortality after allogeneic hematopoietic stem-cell transplantation (HSCT). Historically, GVHD has been diagnosed ...

Masahiro Hirayama, Eiichi Azuma… in General Methods in Biomarker Research and … (2015)

Article

Analysis of patients with atypical hemolytic uremic syndrome treated at the Mie University Hospital: concentration of C3 p.I1157T mutation

Atypical hemolytic uremic syndrome (aHUS) is caused by abnormalities of the complement system and has a significantly poor prognosis. The clinical phenotypes of 12 patients in nine families with aHUS with fami...

Takeshi Matsumoto, ** Fan, Eiji Ishikawa… in International Journal of Hematology (2014)

Living Reference Work Entry In depth

Biomarkers of Graft-Versus-Host Disease

Acute and chronic graft-versus-host disease (GVHD) remains a significant cause of morbidity and mortality after allogeneic hematopoietic stem-cell transplantation (HSCT). Historically, GVHD has been diagnosed ...

Masahiro Hirayama, Eiichi Azuma… in General Methods in Biomarker Research and …

Article

Simultaneous occurrence of gastric antral vascular ectasia and protein-losing enteropathy in chronic graft-versus-host disease

Gastric antral vascular ectasia (GAVE) leading to upper gastrointestinal bleeding is a heterogeneous disorder that is not commonly recognized in hematopoietic stem cell transplantation (HSCT). Protein-losing e...

Masahiro Hirayama, Eiichi Azuma, Atsuko Nakazawa… in International Journal of Hematology (2013)

Article

Flow cytometric analysis of de novo acute lymphoblastic leukemia in childhood: report from the Japanese Pediatric Leukemia/Lymphoma Study Group

Although the antigen expression patterns of childhood acute lymphoblastic leukemia (ALL) are well known, little attention has been given to standardizing the diagnostic and classification criteria. We retrospe...

Shotaro Iwamoto, Takao Deguchi, Hideaki Ohta… in International Journal of Hematology (2011)

Article

HsMAD2 mRNA expression may be a predictor of sensitivity to paclitaxel and survival in neuroblastoma

We investigated the associations between hsMAD2 mRNA expression in tumor cells and sensitivity to paclitaxel or patient prognosis in neuroblastoma.

Kohei Otake, Keiichi Uchida, Kouji Tanaka, Yuhki Koike… in Pediatric Surgery International (2011)

Article

Flow cytometric analysis of de novo acute myeloid leukemia in childhood: report from the Japanese Pediatric Leukemia/Lymphoma Study Group

Hideaki Ohta, Shotaro Iwamoto, Nobutaka Kiyokawa… in International Journal of Hematology (2011)

Article

Elevated Von Willebrand factor propeptide for the diagnosis of thrombotic microangiopathy and for predicting a poor outcome

Thrombotic microangiopathy (TMA) is associated with vascular endothelial cell injury and is sometimes linked with poor outcome. Von Willebrand factor (VWF) propeptide (VWFpp) is considered to be a marker of va...

Naomi Ito-Habe, Hideo Wada, Takeshi Matsumoto… in International Journal of Hematology (2011)

Article

Immunohistochemical Localization of Manserin, a Novel Neuropeptide Derived from Secretogranin II, in Rat Adrenal Gland, and its Upregulation by Physical Stress

We recently identified a novel 40-amino acid neuropeptide designated manserin from the rat brain (Yajima in NeuroReport 15: 1755–1759, 2004). Manserin is highly expressed in pituitary and hypothalamic nuclei, ...

Naoki Kamada, Kaori Tano, Akiko Oyabu… in International Journal of Peptide Research … (2010)

Article

Postnatal Course of Hypoplastic Left Heart Complex and Restrictive Foramen Ovale

Hypoplastic left heart complex is a cardiac malformation at the mildest end of the spectrum of hypoplastic left heart syndrome. Recently, biventricular repair was proposed for such patients without retrograde ...

Koa Hosoki, Yoshihide Mitani, Shin Takabayashi, Hideto Shimpo… in Pediatric Cardiology (2010)

Article

Alternative Fas-mediated cell death pathway is dependent on the different cleavage patterns of procaspase-8

It has been reported that mitochondria-independent or mitochondria-dependent (type I/II) Fas signaling pathways in leukemia cells depend on the amount of active caspase-8. However, Bid molecules, which could n...

Yufeng Li, Lei Qi, Atsushi Iwao, Kentaro Kihira… in Molecular and Cellular Biochemistry (2009)

Article

Pediatric Cardiac Remodeling After Cardiac Resynchronization Therapy

A 1.8-year-old male required a conventional DDD pacemaker for an atrioventricular block after congenital heart surgery. Five years later, heart failure due to left ventricular (LV) dyssynchrony progressed and ...

Shin Takabayashi, Hideto Shimpo, Yoshihide Mitani, Yoshihiro Komada in Pediatric Cardiology (2006)