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Article
Open AccessA study on the fabrication of metal microneedle array electrodes for ECG detection based on low melting point Bi–In–Sn alloys
This study describes the fabrication and characteristics of microneedle array electrodes (MAEs) using Bismuth–Indium–Tin (Bi–In–Sn) alloys. The MAEs consist of 57 pyramid-shaped needles measuring 340 μm wide a...
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Article
Coordinated regulation of interferon and inflammasome signaling pathways by SARS-CoV-2 proteins
Type I and III interferons (IFNs) and the nucleotide-binding domain (NBD) leucine-rich repeat (LRR)-containing receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome play pivotal roles in the pat...
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Article
Human cytomegalovirus IE86 protein aa 136–289 mediates STING degradation and blocks the cGAS-STING pathway
We previously reported that human cytomegalovirus (HCMV) 86 kDa immediate-early 2 gene product (IE86) promotes proteasome-dependent degradation of STING. In the present study, we determined the specific residu...
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Article
Open AccessSpicatoside A derived from Liriope platyphylla root ethanol extract inhibits hepatitis E virus genotype 3 replication in vitro
Hepatitis E virus (HEV) is the causative agent of hepatitis E in humans worldwide. Although hepatitis E is self-limiting without chronic infection development, HEV infection often leads to severe liver disease...
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Anti-varicella-zoster virus activity of cephalotaxine esters in vitro
Harringtonine (HT) and homoharringtonine (HHT), alkaloid esters isolated from the genus Cephalotaxus, exhibit antitumor activity. A semisynthetic HHT has been approved for treatment of chronic myelogenous leukemi...
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Article
Evaluating natural compounds as potential insecticides against three economically important pests, Bemisia tabaci (Hemiptera: Aleyrodidae), Frankliniella occidentalis (Thysanoptera: Thripidae), and Myzus persicae (Hemiptera: Aphididae), on greenhouse sweet peppers
Sweet pepper (Capsicum annuum L.) is one of the major export crops in the Republic of Korea. Currently, synthetic insecticides are frequently used to control major greenhouse pests including Bemisia tabaci (Hemip...
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Article
An ethanol extract of Lysimachia mauritiana exhibits inhibitory activity against hepatitis E virus genotype 3 replication
Hepatitis E virus (HEV) is an etiological agent of acute hepatitis E, a self-limiting disease prevalent in develo** countries. HEV can cause fulminant hepatic failure with high mortality rates in pregnant wo...
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Article
Open AccessInhibition of human cytomegalovirus immediate-early gene expression and replication by the ethyl acetate (EtOAc) fraction of Elaeocarpus sylvestris in vitro
In immunocompromised patients, human cytomegalovirus (HCMV) infection can lead to severe, life-threatening diseases, such as pneumonitis, hepatitis, gastrointestinal tract disease, and retinitis. We previously...
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Article
Effects of compounds isolated from a Litsea japonica fruit extract on the TNF-α signaling pathway and cell viability
Tumor necrosis factor-α (TNF-α) plays an important role in inflammatory responses. Deregulated activation of TNF-α signaling is associated with various inflammatory diseases. In view of the finding that the se...
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Article
Safety of using Escherichia coli bacteriophages as a sanitizing agent based on inflammatory responses in rats
Use of bacteriophages as sanitizing agents has received much attention. However, safety in humans is debatable. To determine inflammatory immune responses against bacteriophages, rats were treated with a 8 log...
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Characterization of the rapamycin-inducible EBV LMP1 activation system
Epstein-Barr virus (EBV) latent infection membrane protein 1 (LMP1) is required for EBV-mediated B lymphocyte transformation into proliferating lymphoblastoid cell lines (LCL). LMP1 oligomerizes spontaneously ...
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Article
The extract of Tamarindus indica L. suppresses IKKβ activity and NF-κB-dependent lymphoblastoid cell line survival
The NF-κB family of transcription factors is a critical regulator for the cell survival by inducing the expression of anti-apoptotic genes. In this study, we found that a seventy percent ethanol extract of Tamari...
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Cellular imaging assay for early evaluation of an apoptosis inducer
The objective of this study was to propose a feasibility of a cellular imaging assay as an alternative to the conventional cytotoxicity assay, such as MTS assay, for apoptosis monitoring. As an apoptosis monit...
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Article
Open AccessThe role of promoter methylation in Epstein-Barr virus (EBV) microRNA expression in EBV-infected B cell lines
Epstein-Barr virus (EBV) microRNAs (miRNAs) are expressed in EBV-associated tumors and cell lines, but the regulation mechanism of their expression is unclear yet. We investigated whether the expression of EBV...
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Article
Roles of TRAF2 and TRAF3 in Epstein-Barr virus latent membrane protein 1-induced alternative NF-κB activation
Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1)-induced NF-κB activation is essential for EBV-transformed B cell survival. LMP1 has two C-terminal cytoplasmic domains referred to as C-Terminal Activa...
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Regulation of Cellular Genes by Cytomegalovirus
