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An ethanol extract of Lysimachia mauritiana exhibits inhibitory activity against hepatitis E virus genotype 3 replication

  • Virology
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Abstract

Hepatitis E virus (HEV) is an etiological agent of acute hepatitis E, a self-limiting disease prevalent in develo** countries. HEV can cause fulminant hepatic failure with high mortality rates in pregnant women, and genotype 3 is reported to trigger chronic hepatitis in immunocompromised individuals worldwide. Screening of plant extracts for compounds with potential anti-HEV effects led to the identification of a 70% ethanol extract of Lysimachia mauritiana (LME) that interferes with replication of the swine HEV genotype 3 replicon. Furthermore, LME significantly inhibited replication of HEV genotype 3 and expression of HEV ORF2 in infected cells without exerting cytotoxic effects. Collectively, our findings demonstrate the potential utility of LME in the development of novel antiviral drugs against HEV infection.

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Authors and Affiliations

  1. Department of Life Science, Gachon University, Seongnam, 13120, Republic of Korea

    Seong Eun **, Jung-Eun Kim & Yoon-Jae Song

  2. College of Pharmacy, Gachon University, Incheon, 21936, Republic of Korea

    Sun Yeou Kim

  3. Gachon Institute of Pharmaceutical Science, Gachon University, Incheon, 21936, Republic of Korea

    Sun Yeou Kim

  4. Department of Electronic Engineering, Gachon University, Seongnam, 13120, Republic of Korea

    Bang Ju Park

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  1. Seong Eun **
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Correspondence to Yoon-Jae Song.

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**, S.E., Kim, JE., Kim, S.Y. et al. An ethanol extract of Lysimachia mauritiana exhibits inhibitory activity against hepatitis E virus genotype 3 replication. J Microbiol. 55, 984–988 (2017). https://doi.org/10.1007/s12275-017-7477-1

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  • DOI: https://doi.org/10.1007/s12275-017-7477-1

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