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Article
Open AccessThe Hippo pathway effector YAP inhibits HIF2 signaling and ccRCC tumor growth
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Characterization of Smoothened Phosphorylation and Activation
The GPCR-family protein Smoothened (Smo) is an obligatory signal transducer of the Hedgehog (Hh) signaling pathway. Binding of Hh to its receptor Patched (Ptc) alleviates Ptc-mediated inhibition of Smo, allowi...
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Article
Open AccessOverlap** functions of the MAP4K family kinases Hppy and Msn in Hippo signaling
The Hippo (Hpo) tumor suppressor pathway is an evolutionarily conserved signaling pathway that controls tissue growth and organ size in species ranging from Drosophila to human, and its malfunction has been impli...
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Article
Open AccessInhibition of Pseudomonas aeruginosa with a recombinant RNA-based viral vector expressing human β-defensin 4
Harassed with extensive epithelial burn wounds, patients can be affected by complications, such as infection, hypovolemic shock, hypothermia, and respiratory failure. Immediate first aid and followed supportiv...