56 Result(s)
within
Yong-Gao **a
Life Sciences
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Article
Development of 96 SNP markers for Amorphophallus yuloensis, a species distributed across southwestern China
Amorphophallus yuloensis is a species endemic to southwestern China. Due to the isolated nature of its karst limestone habitat, this species is found in small and isolated populations. Because wild populations of...
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Rice PIFs: Critical regulators in rice development and stress response
Phytochrome-interacting factors (PIFs) belong to a subfamily of the basic helix-loop-helix (bHLH) family of transcription factors, which serve as a “hub” for development and growth of plants. They have the cap...
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Map** the gene of a maize leaf senescence mutant and understanding the senescence pathways by expression analysis
Narrowing down to a single putative target gene behind a leaf senescence mutant and constructing the regulation network by proteomic method.
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YY1 regulates the proliferation and invasion of triple-negative breast cancer via activating PLAUR
It is well-established that breast cancer is a highly prevalent malignancy among women, emphasizing the need to investigate mechanisms underlying its pathogenesis and metastasis. In this study, the Gene Expres...
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Open AccessAssociation between SUMF1 polymorphisms and COVID-19 severity
Evidence shows that genetic factors play important roles in the severity of coronavirus disease 2019 (COVID-19). Sulfatase modifying factor 1 (SUMF1) gene is involved in alveolar damage and systemic inflammatory ...
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miR-330-3p alleviates the progression of atherosclerosis by downregulating AQP9
Atherosclerosis (AS) is the main cause of cardiovascular diseases. However, the role of AQP9 in AS is not well understood. In the present study, we predicted that miR-330-3p might regulate AQP9 in AS through b...
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Open AccessMETTL13 facilitates cell growth and metastasis in gastric cancer via an eEF1A/HN1L positive feedback circuit
Although improved treatment could inhibit progression of gastric cancer (GC), the recurrence and metastasis remain challenging issues. Methyltransferase like 13 (METTL13) has been implicated in most human canc...
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Open AccessAn update regarding the role of WNK kinases in cancer
Mammalian WNK kinases (WNKs) are serine/threonine kinases that contain four members, WNK1–4. They function to maintain ion homeostasis and regulate blood pressure in mammals. Recent studies have revealed that ...
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Open AccessmiR-15a and miR-20b sensitize hepatocellular carcinoma cells to sorafenib through repressing CDC37L1 and consequent PPIA downregulation
Sorafenib is a classical targeted drug for the treatment of advanced hepatocellular carcinoma (HCC), but intrinsic resistance severely limited its therapeutic effects. In the present study, we aimed to identif...
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Open AccessEffects of grazing disturbance of spatial distribution pattern and interspecies relationship of two desert shrubs
Grazing significantly affects the distribution, growth, and productivity of shrubs. In this study, we evaluated the effects of grazing disturbance on the spatial distribution patterns and interspecific relatio...
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Open AccessIFNAR1 gene mutation may contribute to developmental stuttering in the Chinese population
Developmental stuttering is the most common form of stuttering without apparent neurogenic or psychogenic impairment. Recently, whole-exome sequencing (WES) has been suggested to be a promising approach to stu...
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Open AccessWaist-to-height ratio, an optimal anthropometric indicator for metabolic dysfunction associated fatty liver disease in the Western Chinese male population
Non-alcoholic fatty liver disease (NAFLD) has been entitled as metabolic-dysfunction associated fatty liver disease (MAFLD). Therefore anthropometric indicators of adiposity may provide a non-invasive predicti...
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Open AccessCSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling
The function of Casein kinase 2 beta (CSNK2B) in human malignancies has drawn increasing attention in recent years. However, its role in colorectal cancer (CRC) remains unclear. In the present study, we aimed to ...
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Prediction of Ubiquitin Ligase Nrdp1-Associated Proteins in Glioma Database
The ubiquitin proteasome pathway is conserved from yeast to mammals and is necessary for the targeted degradation of most short-lived proteins in eukaryotic cells. Its protein substrates include cell cycle reg...
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Development of SNP markers for conservation genetic monitoring of Amorphophallus krausei based on RAD sequencing
Amorphophallus krausei is a perennial plant which is native to Southeast Asia. Wild populations of A. krausei are declining in China due to anthropogenic threats. Genetic monitoring is an important tool for the c...
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Open AccessKLF4-mediated upregulation of CD9 and CD81 suppresses hepatocellular carcinoma development via JNK signaling
Tetraspanins CD9 and CD81 frequently serve as the surface markers of exosomes, which are involved in intercellular communication during tumor progression. KLF4 is a well-known tumor suppressor in various cance...
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Open AccessA phenomics-based approach for the detection and interpretation of shared genetic influences on 29 biochemical indices in southern Chinese men
Phenomics provides new technologies and platforms as a systematic phenome-genome approach. However, few studies have reported on the systematic mining of shared genetics among clinical biochemical indices base...
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Development of 30 SNP markers for Amorphophallus yunnanensis based on RAD sequencing
Amorphophallus yunnanensis is a tuber-producing plant species distributed in Southeastern Asia. Wild populations of A. yunnanensis are threatened as a result of human activity. To facilitate future work on the ge...
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Newly Developed Genomic SSRs Reveal Genetic Diversity in Wild and Cultivated Amorphophallus albus Germplasms
Amorphophallus albus is a crop plant of great economic value in glucomannan production. However, the cultivation industry surrounding this plant is so new that no comprehensive studies have been conducted on its ...
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Open AccessAdrenomedullin alleviates the pyroptosis of Leydig cells by promoting autophagy via the ROS–AMPK–mTOR axis
Adrenomedullin (ADM) exerts anti-oxidant, anti-inflammatory and anti-apoptotic effects in Leydig cells. However, the role and mechanism of ADM in the pyroptosis of Leydig cells are poorly understood. This stud...
