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Article
TBC1D10B promotes tumor progression in colon cancer via PAK4‑mediated promotion of the PI3K/AKT/mTOR pathway
This study aimed to explore the expression, function, and mechanisms of TBC1D10B in colon cancer, as well as its potential applications in the diagnosis and treatment of the disease.The expression levels of TB...
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Article
In situ Preparation and Visible-light-driven Photocatalytic Degradation Performance of Nano 3C-SiC@Multilayer Graphene Oxide Heterostructure
Nano 3C-SiC@multilayer graphene oxide (NS@MGO) heterostructure was in situ prepared by carbothermal reduction of pyrolyzed precursor composed of highly dispersed cured phenolic resin and silicon dioxide derived f...
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Article
Open AccessmiRNA-206-3p alleviates LPS-induced acute lung injury via inhibiting inflammation and pyroptosis through modulating TLR4/NF-κB/NLRP3 pathway
Acute lung injury (ALI) is life-threatening. MicroRNAs (miRNAs) are often abnormally expressed in inflammatory diseases and are closely associated with ALI. This study investigates whether miRNA-206-3p attenua...
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Article
Open AccessCausative role of a novel intronic indel variant in FBN1 and maternal germinal mosaicism in Marfan syndrome
Marfan syndrome (MFS) is an autosomal dominant connective tissue disease with wide clinical heterogeneity, and mainly caused by pathogenic variants in fibrillin-1 (FBN1).
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Article
SDCBP modulates tumor microenvironment, tumor progression and anti-PD1 efficacy in colorectal cancer
Anti-programmed cell death 1 (aPD1) therapy has yielded limited success in patients with colorectal cancer (CRC). Syndecan binding protein (SDCBP), encodes a PDZ domain-containing protein that is essential for...
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Article
Open AccessA freely precessing magnetar following an X-ray outburst
Magnetars—highly magnetized neutron stars—are thought to be the most likely progenitors for fast radio bursts (FRBs). Freely precessing magnetars are further invoked to explain the repeating FRBs. We report he...
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Article
High pyroptosis activity in pancreatic adenocarcinoma: poor prognosis and oxaliplatin resistance
Pyroptosis, as a type of inflammatory programmed cell death, has been studied in inflammatory diseases and numerous cancers but its role in pancreatic ductal adenocarcinoma (PDAC) remains further exploration.
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Article
Open AccessStem Leydig cells support macrophage immunological homeostasis through mitochondrial transfer in mice
As testicular mesenchymal stromal cells, stem Leydig cells (SLCs) show great promise in the treatment of male hypogonadism. The therapeutic functions of mesenchymal stromal cells are largely determined by thei...
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Article
Development of 96 SNP markers for Amorphophallus yuloensis, a species distributed across southwestern China
Amorphophallus yuloensis is a species endemic to southwestern China. Due to the isolated nature of its karst limestone habitat, this species is found in small and isolated populations. Because wild populations of...
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Article
Protean career orientation, supervisor perceptions and organizational career growth: a moderated mediation model
Protean career orientation is important for people to achieve career development in the unstable career environment, but less is known about how this orientation affects one’s career development within the org...
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Article
Open AccessHigh expression of TBRG4 in relation to unfavorable outcome and cell ferroptosis in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common type of malignant liver tumor with poor prognosis. In this study, we investigated the expression of transforming growth factor beta regulator 4 (TBRG4) in HCC ...
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Article
Open AccessCorrection: Bioactive VS4-based sonosensitizer for robust chemodynamic, sonodynamic and osteogenic therapy of infected bone defects
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Article
Open AccessExperimentally validated design principles of heteroatom-doped-graphene-supported calcium single-atom materials for non-dissociative chemisorption solid-state hydrogen storage
Non-dissociative chemisorption solid-state storage of hydrogen molecules in host materials is promising to achieve both high hydrogen capacity and uptake rate, but there is the lack of non-dissociative hydroge...
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Article
Open AccessCyclic loading changes the taproot's tensile properties and reinforces the soil via the shrub's taproot in semi-arid areas, China
This study aimed to reveal the soil reinforcement by shrub root systems after repeated stress from external forces, such as high winds and runoff, for extended periods in the wind-hydraulic compound erosion zo...
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Article
Open AccessHepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor)
A lasting imbalance between fatty acid synthesis and consumption leads to non-alcoholic fatty liver disease (NAFLD), coupled with hepatitis and insulin resistance. Yet the details of the underlying mechanisms ...
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Article
Open AccessBioactive VS4-based sonosensitizer for robust chemodynamic, sonodynamic and osteogenic therapy of infected bone defects
Most bone defects caused by bone disease or trauma are accompanied by infection, and there is a high risk of infection spread and defect expansion. Traditional clinical treatment plans often fail due to issues...
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Article
Open AccessCorrection: YangZheng **aoJi exerts anti-tumour growth effects by antagonising the effects of HGF and its receptor, cMET, in human lung cancer cells
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Article
Rice PIFs: Critical regulators in rice development and stress response
Phytochrome-interacting factors (PIFs) belong to a subfamily of the basic helix-loop-helix (bHLH) family of transcription factors, which serve as a “hub” for development and growth of plants. They have the cap...
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Chapter and Conference Paper
Study on Cumulative Characteristics of Transformer Windings Based on Finite Element Simulation
The study on cumulative characteristics of transformer windings is of great significance to improve the short-circuit withstand ability of power transformers. Current research on the cumulative characteristics...
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Chapter and Conference Paper
Design and Implementation of College Student Volunteer Service Platform Based on Collaborative Filtering Algorithm
In the past decade, voluntary service has mushroomed vigorously
