35 Result(s)
within
Yong Bum Kim
English
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Article
Genotoxicity and safety pharmacology of the rVSVInd(GML)-mspSGtc vaccine against SARS-CoV-2 in Sprague–Dawley rats and Beagle dogs
The emergence of coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to a pandemic, prompting rapid vaccine development. Although vaccines are effective, t...
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Open AccessApplication of multiple-finding segmentation utilizing Mask R-CNN-based deep learning in a rat model of drug-induced liver injury
Drug-induced liver injury (DILI) presents significant diagnostic challenges, and recently artificial intelligence-based deep learning technology has been used to predict various hepatic findings. In this study...
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Preclinical evaluation of general toxicity and safety pharmacology of a receptor-binding domain-based COVID-19 subunit vaccine in various animal models
The coronavirus disease 2019 pandemic has resulted in the introduction of several naïve methods of vaccine development, which have been used to prepare novel viral vectors and mRNA-based vaccines. However, rel...
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Open AccessA comparative study on the implementation of deep learning algorithms for detection of hepatic necrosis in toxicity studies
Deep learning has recently become one of the most popular methods of image analysis. In non-clinical studies, several tissue slides are generated to investigate the toxicity of a test compound. These are conve...
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Open AccessSegmentation algorithm can be used for detecting hepatic fibrosis in SD rat
Liver fibrosis is an early stage of liver cirrhosis. As a reversible lesion before cirrhosis, liver failure, and liver cancer, it has been a target for drug discovery. Many antifibrotic candidates have shown p...
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Preclinical safety assessment of the suction-assisted intradermal injection of the SARS-CoV-2 DNA vaccine candidate pGO-1002 in white rabbit
pGO-1002, a non-viral DNA vaccine that expresses both spike and ORF3a antigens of SARS-CoV-2, is undergoing phase 1 and phase 2a clinical trials in Korea and the US. A preclinical repeated-dose toxicity study ...
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Open AccessPreparing pathological data to develop an artificial intelligence model in the nonclinical study
Artificial intelligence (AI)-based analysis has recently been adopted in the examination of histological slides via the digitization of glass slides using a digital scanner. In this study, we examined the effe...
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Article
Whole-Body Control and Angular Momentum Regulation using Torque Sensors for Quadrupedal Robots
Ground reaction force (GRF) plays an integral role in legged robots to control interaction with the ground. However, most techniques in whole-body controller for quadrupedal robots do not explicitly take into ...
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Subacute dermal toxicity of perfluoroalkyl carboxylic acids: comparison with different carbon-chain lengths in human skin equivalents and systemic effects of perfluoroheptanoic acid in Sprague Dawley rats
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are used in various fields but raise concerns regarding human health and environmental consequences. Among PFASs, perfluorooctanoic acid (PFOA) and short-c...
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Article
Open AccessAuthor Correction: Multimodal imaging analyses in patients with genetic and sporadic forms of small vessel disease
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessNatural course of fatty liver in 36,195 South Korean adults
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver disease, and yet the natural course remains unclear. Study population included 36,195 individuals who participated in a health-screeni...
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Article
Sampling-based motion planning of manipulator with goal-oriented sampling
A sampling-based planning algorithm is one of the most powerful tools for collision avoidance in the motion planning of manipulators. However, this algorithm takes a long time to generate motions of the manipu...
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Open AccessMultimodal imaging analyses in patients with genetic and sporadic forms of small vessel disease
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is thought to be a pure genetic form of subcortical vascular cognitive impairment (SVCI). The aim of this st...
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Article
Open AccessContinuous crop** of endangered therapeutic plants via electron beam soil-treatment and neutron tomography
Various medicinal plants are threatened with extinction owing to their over-exploitation and the prevalence of soil borne pathogens. In this study, soils infected with root-rot pathogens, which prevent continu...
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Open AccessHigher incidence of sperm granuloma in the epididymis of C57BL/6N mice
C57BL/6N mice are inbred strains widely used in biomedical research. Hence, a large amount of basic data has been accumulated. However, in the field of histopathology, spontaneous data for relatively younger m...
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Article
Twenty-six-week oral carcinogenicity study of 3-monochloropropane-1,2-diol in CB6F1-rasH2 transgenic mice
The carcinogenic potential of 3-monochloro-1,2-propanediol (3-MCPD) was evaluated in a short-term carcinogenicity testing study using CB6F1 rasH2-Tg (rasH2-Tg) mice. 3-MCPD is found in many foods and food ingred...
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Open AccessReference values of clinical pathology parameters in cynomolgus monkeys (Macaca fascicularis) used in preclinical studies
Nonhuman primates are increasingly used in biomedical research since they are highly homologous to humans compared to other rodent animals. However, there is limited reliable reference data of the clinical pat...
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Article
Computation of minimum contact forces of multifingered robot hand with soft fingertips
In the human hand, the softness of a fingertip plays a significant role on stable gras** and dexterous manipulation. This paper presents a method of computing minimum grasp forces of a multi-fingered hand wi...
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Article
Comparison of the toxicity of aluminum oxide nanorods with different aspect ratio
Aluminum oxide nanoparticles are listed among 14 high-priority nanomaterials published by the Organization for Economic Co-operation and Development, but limited information is available on their potential haz...
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Comparative gene expression analysis in the liver, kidney and blood vessels during renal injury after repeated exposure to tacrolimus in Sprague-Dawley rats
To elucidate the molecular mechanisms associated with renal injury based on multi-organ interactions, we simultaneously examined the changes in expression profiles of the liver, kidneys, and blood vessels afte...
