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Article
Genotoxicity and safety pharmacology of the rVSVInd(GML)-mspSGtc vaccine against SARS-CoV-2 in Sprague–Dawley rats and Beagle dogs
The emergence of coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to a pandemic, prompting rapid vaccine development. Although vaccines are effective, t...
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Article
Determination of pepsin in human saliva using pepsin-susceptible peptide reporter and colorimetric dipstick assay: a prospective, cross-sectional study
A simple and effective pepsin detection assay is reported based on a pepsin-susceptible peptide (PSP) reporter degradation strategy. PSP, which can be specifically cleaved by pepsin, was modified with fluores...
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Article
Neural network method and multiscale modeling of the COVID-19 epidemic in Korea
A multiscale modeling procedure is proposed with integrating dynamical models and small-world network models to describe the transmission of COVID-19 in Korea, which featured many infections due to aggregation...
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Article
Locally conservative discontinuous bubble scheme for Darcy flow and its application to Hele-Shaw equation based on structured grids
In this paper, we present an algorithm to solve the Darcy flow coupled with a transport for the interface tracking and apply the algorithm to solve a Hele-Shaw flow. The main challenge in the solution of the H...
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Article
Next-Generation Sequencing Results Vary Between Cultured and Uncultured Microbes
Next-generation sequencing (NGS) technology has led to innovations in environmental metagenomics and investigations involving humans and microbes. However, it is necessary to analyze the components that will a...
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Article
Open AccessAdipose stem cell-derived extracellular vesicles ameliorates corticosterone-induced apoptosis in the cortical neurons via inhibition of ER stress
Corticosterone (CORT) can induce neuronal damage in various brain regions, including the cerebral cortex, the region implicated in depression. However, the underlying mechanisms of these CORT-induced effects r...
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Article
Open AccessDiscovering spatiotemporal patterns of COVID-19 pandemic in South Korea
A novel severe acute respiratory syndrome coronavirus 2 emerged in December 2019, and it took only a few months for WHO to declare COVID-19 as a pandemic in March 2020. It is very challenging to discover compl...
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Article
Open AccessComparative analysis of genetic characterization of β-lactam-resistant Escherichia coli from bulk tank milk in Korea
This study was conducted to analyze the genetic characteristics of 41 β-lactam-resistant Escherichia coli isolates, which are one of the common causes of environmental mastitis, isolated from the bulk tank milk o...
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Article
Open AccessA prospectively collected observational study of pelvic floor muscle strength and erectile function using a novel personalized extracorporeal perineometer
To investigate the association between pelvic floor muscle strength and erectile function in a prospectively collected observational cohort. 270 male volunteers were prospectively collected and grouped by Inte...
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Article
Locally Conservative Immersed Finite Element Method for Elliptic Interface Problems
In this paper, we introduce a locally conservative enriched immersed finite element method (EIFEM) to tackle the elliptic problem with interface. The immersed finite element is useful for handling interface wi...
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Article
Open AccessAsparagus cochinchinensis extract ameliorates menopausal depression in ovariectomized rats under chronic unpredictable mild stress
Depression is a serious and common psychiatric disorder generally affecting more women than men. A woman’s risk of develo** depression increases steadily with age, and higher incidence is associated with the...
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Article
Dieckol or phlorofucofuroeckol extracted from Ecklonia cava suppresses lipopolysaccharide-mediated human breast cancer cell migration and invasion
The phlorotannin compounds, dieckol and phlorofucofuroeckol (PFF), extracted from Ecklonia cava, have been suggested to exhibit anti-inflammatory, anti-adipogenic or anti-tumorigenic activity. However, role of di...
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Article
Open AccessMetabolomics approach to serum biomarker for laxative effects of red Liriope platyphylla in loperamide-induced constipation of SD rats
Red Liriope platyphylla (RLP) is a known herbal medicine used in the treatment of some chronic diseases including constipation, neurodegenerative disorders, diabetes and obesity. To determine and characterize put...
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Article
Open AccessComparison of scopolamine-induced cognitive impairment responses in three different ICR stocks
Cognitive impairment responses are important research topics in the study of degenerative brain diseases as well as in understanding of human mental activities. To compare response to scopolamine (SPL)-induced...
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Article
Open AccessOuter membrane vesicles from β-lactam-resistant Escherichia coli enable the survival of β-lactam-susceptible E. coli in the presence of β-lactam antibiotics
Outer membrane vesicles (OMVs) containing various bacterial compounds are released from mainly gram-negative bacteria. Secreted OMVs play important roles in the ability of a bacterium to defend itself, and thu...
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Article
Optimization of Ionic Liquid Pretreatment of Mixed Softwood by Response Surface Methodology and Reutilization of Ionic Liquid from Hydrolysate
We investigated the feasibility of producing bioethanol from mixed softwood pretreated with the ionic liquid 1-butyl-3-methylimidazolium acetate ([Bmim]Ac). The optimal pretreatment conditions were determined ...
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Article
Open AccessEffect of weight loss on circulating fatty acid profiles in overweight subjects with high visceral fat area: a 12-week randomized controlled trial
Significant associations between visceral fat and alterations in plasma fatty acids have been identified in overweight individuals. However, there are scant data regarding the relationships of the visceral fat...
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Article
Open AccessPrevalence and characterization of Salmonella in two integrated broiler operations in Korea
Vertical integration of the broiler industry allows producers to combine different biosecurity and sanitation practices, housing technologies, and feeding regimens to improve food safety. The purpose of this s...
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Article
Factors that influence lower urinary tract symptom (LUTS)-related quality of life (QoL) in a healthy population
The aim of this study was to evaluate the factors affecting the lower urinary tract symptoms (LUTS) related quality of life (QoL) score.
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Article
Age-dependent alterations in serum cytokines, peripheral blood mononuclear cell cytokine production, natural killer cell activity, and prostaglandin F2α
This study aimed to determine age-dependent alterations in serum cytokines, peripheral blood mononuclear cell (PBMC) cytokine production, natural killer (NK) cell activity, and urinary 8-epi-prostaglandin F2α (PG...
