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Open AccessIndex tumor location affected early biochemical recurrence after radical prostatectomy in patients with negative surgical margin: a retrospective study
Index tumors are the most aggressive tumors of the prostate. However, their clinical significance remains unclear. This study aimed to assess the incidence of index tumor location according to the zonal origin...
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Article
Open AccessA data-driven ultrasound approach discriminates pathological high grade prostate cancer
Accurate prostate cancer screening is imperative for reducing the risk of cancer death. Ultrasound imaging, although easy, tends to have low resolution and high inter-observer variability. Here, we show that o...
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Article
Open AccessAutomated acquisition of explainable knowledge from unannotated histopathology images
Deep learning algorithms have been successfully used in medical image classification. In the next stage, the technology of acquiring explainable knowledge from medical images is highly desired. Here we show th...
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Article
Histopathological findings of pregnancy-induced hypertension: histopathology of early-onset type reflects two-stage disorder theory
The placental tissues of pregnancy-induced hypertension (PIH) patients exhibit multiple infarctions, acute atherosis, distal villous hypoplasia, and increased syncytial knots. However, these findings are not o...
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Article
Open AccessQuantitative diagnosis of breast tumors by morphometric classification of microenvironmental myoepithelial cells using a machine learning approach
Machine learning systems have recently received increased attention for their broad applications in several fields. In this study, we show for the first time that histological types of breast tumors can be cla...
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Article
Open AccessTumour and immune cell dynamics explain the PSA bounce after prostate cancer brachytherapy
Interstitial brachytherapy for localised prostate cancer may be followed by transient increases in prostate-specific antigen (PSA) that resolve without therapy. Such PSA bounces may be associated with an impro...
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Article
Quantitative analysis of nuclear shape in oral squamous cell carcinoma is useful for predicting the chemotherapeutic response
The number of people afflicted with oral carcinoma in Japan has increased in recent years. Although preoperative neoadjuvant therapy with cisplatin and 5-fluorouracil are performed, chemotherapeutic response v...
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Open AccessSupratentorial extraventricular anaplastic ependymoma in an adult with repeated intratumoral hemorrhage
We report the case of a 61-year-old man with supratentorial extraventricular anaplastic ependymoma who presented with repeated intratumoral hemorrhage. The patient was admitted with headache. Computed tomograp...
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Article
Open AccessInferior vena cava tumor thrombus after partial nephrectomy for renal cell carcinoma
Partial nephrectomy is now the gold standard treatment for small renal tumors. Local recurrence is a major problem after partial nephrectomy, and local recurrence in the remnant kidney after partial nephrectom...
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Article
Roles of fine-needle aspiration and core needle biopsy in the diagnosis of breast cancer
There is controversy regarding which of the two biopsy methods, fine-needle aspiration (FNA) or core needle biopsy (CNB), should be routinely employed for diagnosis of breast cancer. The aim of this study was ...