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  1. Article

    Open Access

    Index tumor location affected early biochemical recurrence after radical prostatectomy in patients with negative surgical margin: a retrospective study

    Index tumors are the most aggressive tumors of the prostate. However, their clinical significance remains unclear. This study aimed to assess the incidence of index tumor location according to the zonal origin...

    Yoshihiko Ogata, Jun Akatsuka, Yuki Endo, Hikaru Mikami, Masato Yanagi in BMC Urology (2024)

  2. Article

    Open Access

    A data-driven ultrasound approach discriminates pathological high grade prostate cancer

    Accurate prostate cancer screening is imperative for reducing the risk of cancer death. Ultrasound imaging, although easy, tends to have low resolution and high inter-observer variability. Here, we show that o...

    Jun Akatsuka, Yasushi Numata, Hiromu Morikawa, Tetsuro Sekine in Scientific Reports (2022)

  3. Article

    Open Access

    Automated acquisition of explainable knowledge from unannotated histopathology images

    Deep learning algorithms have been successfully used in medical image classification. In the next stage, the technology of acquiring explainable knowledge from medical images is highly desired. Here we show th...

    Yoichiro Yamamoto, Toyonori Tsuzuki, Jun Akatsuka, Masao Ueki in Nature Communications (2019)

  4. No Access

    Article

    Histopathological findings of pregnancy-induced hypertension: histopathology of early-onset type reflects two-stage disorder theory

    The placental tissues of pregnancy-induced hypertension (PIH) patients exhibit multiple infarctions, acute atherosis, distal villous hypoplasia, and increased syncytial knots. However, these findings are not o...

    Ayako Tateishi, Satoshi Ohira, Yoichiro Yamamoto, Hiroyuki Kanno in Virchows Archiv (2018)

  5. Article

    Open Access

    Quantitative diagnosis of breast tumors by morphometric classification of microenvironmental myoepithelial cells using a machine learning approach

    Machine learning systems have recently received increased attention for their broad applications in several fields. In this study, we show for the first time that histological types of breast tumors can be cla...

    Yoichiro Yamamoto, Akira Saito, Ayako Tateishi, Hisashi Shimojo in Scientific Reports (2017)

  6. Article

    Open Access

    Tumour and immune cell dynamics explain the PSA bounce after prostate cancer brachytherapy

    Interstitial brachytherapy for localised prostate cancer may be followed by transient increases in prostate-specific antigen (PSA) that resolve without therapy. Such PSA bounces may be associated with an impro...

    Yoichiro Yamamoto, Chetan P Offord, Go Kimura in British Journal of Cancer (2016)

  7. No Access

    Article

    Quantitative analysis of nuclear shape in oral squamous cell carcinoma is useful for predicting the chemotherapeutic response

    The number of people afflicted with oral carcinoma in Japan has increased in recent years. Although preoperative neoadjuvant therapy with cisplatin and 5-fluorouracil are performed, chemotherapeutic response v...

    Maki Ogura, Yoichiro Yamamoto, Hitoshi Miyashita in Medical Molecular Morphology (2016)

  8. Article

    Open Access

    Supratentorial extraventricular anaplastic ependymoma in an adult with repeated intratumoral hemorrhage

    We report the case of a 61-year-old man with supratentorial extraventricular anaplastic ependymoma who presented with repeated intratumoral hemorrhage. The patient was admitted with headache. Computed tomograp...

    Naotaka Iwamoto, Yasuo Murai, Yoichiro Yamamoto, Koji Adachi in Brain Tumor Pathology (2014)

  9. Article

    Open Access

    Inferior vena cava tumor thrombus after partial nephrectomy for renal cell carcinoma

    Partial nephrectomy is now the gold standard treatment for small renal tumors. Local recurrence is a major problem after partial nephrectomy, and local recurrence in the remnant kidney after partial nephrectom...

    Jun Akatsuka, Yasutomo Suzuki, Tsutomu Hamasaki, Takao Shindo in BMC Research Notes (2014)

  10. No Access

    Article

    Roles of fine-needle aspiration and core needle biopsy in the diagnosis of breast cancer

    There is controversy regarding which of the two biopsy methods, fine-needle aspiration (FNA) or core needle biopsy (CNB), should be routinely employed for diagnosis of breast cancer. The aim of this study was ...

    Tomoko Kurita, Shin-ichi Tsuchiya, Yasuhiko Watarai, Yoichiro Yamamoto in Breast Cancer (2012)