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Article
Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease
Microglial involvement in Alzheimer’s disease (AD) pathology has emerged as a risk-determining pathogenic event. While apolipoprotein E (APOE) is known to modify AD risk, it remains unclear how microglial apoE im...
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Article
Open AccessAPOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids
The apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer’s disease (AD); however, how it modulates brain homeostasis is not clear. The apoE protein is a major lipid carrier in the brain...
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Article
Open AccessNetwork structure of mobile phone addiction and anxiety symptoms among rural Chinese adolescents
The incidence of mobile phone addiction among adolescents in rural areas of China is increasing year by year, and has already exceeded that of some cities. And phone addiction increases the risk of anxiety and...
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Article
Open AccessCorrection: Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology
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Open AccessTrem2 H157Y increases soluble TREM2 production and reduces amyloid pathology
The rare p.H157Y variant of TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) was found to increase Alzheimer’s disease (AD) risk. This mutation is located at the cleavage site of TREM2 extracellular domai...
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Article
Open AccessPrediction of small-for-gestational-age neonates at 33–39 weeks’ gestation in China: logistic regression modeling of the contributions of second- and third-trimester ultrasound data and maternal factors
A screening model for prediction of small-for-gestational-age (SGA) neonates (SGAp) was established by logistic regression using ultrasound data and maternal factors (MF). We aimed to evaluate the ability of S...
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Article
Efficient Removal of Cr(VI) from Aqueous Solution by Fe-Mn Oxide-Modified Biochar
Removal of Cr(VI) is of great concern due to its high mobility and toxicity in the natural environment. In this study, Fe-Mn oxide-modified biochar composite (FMBC) was prepared by impregnation to remove Cr(VI...