-
Article
Open AccessABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism
ABCA7 loss-of-function variants are associated with increased risk of Alzheimer’s disease (AD). Using ABCA7 knockout human iPSC models generated with CRISPR/Cas9, we investigated the impacts of ABCA7 deficiency o...
-
Article
DOE: database offloading engine for accelerating SQL processing
The CPU-Accelerator heterogeneous systems have demonstrated performance and efficiency benefits on DBMSs. However, the CPU-Cache-DRAM architecture can not fully utilize the bandwidth of DRAMs such that in-memo...
-
Article
Open AccessWGCNA and transcriptome profiling reveal hub genes for key development stage seed size/oil content between wild and cultivated soybean
Soybean is one of the most important oil crops in the world. The domestication of wild soybean has resulted in significant changes in the seed oil content and seed size of cultivated soybeans. To better unders...
-
Article
Open AccessAPOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids
The apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer’s disease (AD); however, how it modulates brain homeostasis is not clear. The apoE protein is a major lipid carrier in the brain...
-
Chapter and Conference Paper
Exploring the Empowerment of Chinese Women’s Discourse in Tik Tok
In the new media environment, women are no longer the recipients of information, but rather the producers and consumers of information. The media image of women has become more diverse. Tik Tok is a product of...
-
Article
Suppression of Wnt/β-Catenin Signaling Is Associated with Downregulation of Wnt1, PORCN, and Rspo2 in Alzheimer’s Disease
Wnt and R-spondin (Rspo) proteins are two major types of endogenous Wnt/β-catenin signaling agonists. While Wnt/β-catenin signaling is greatly diminished in Alzheimer’s disease (AD), it remains to be elucidate...
-
Article
Open AccessLRP1 is a neuronal receptor for α-synuclein uptake and spread
The aggregation and spread of α-synuclein (α-Syn) protein and related neuronal toxicity are the key pathological features of Parkinson’s disease (PD) and Lewy body dementia (LBD). Studies have shown that patho...
-
Article
Correction to: Apolipoprotein E regulates lipid metabolism and α‑synuclein pathology in human iPSC‑derived cerebral organoids
-
Article
Open AccessApolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids
APOE4 is a strong genetic risk factor for Alzheimer’s disease and Dementia with Lewy bodies; however, how its expression impacts pathogenic pathways in a human-relevant system is not clear. Here using human iPSC-...
-
Article
Open AccessAuthor Correction: APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids
-
Article
Open AccessAPOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids
APOE4 is the strongest genetic risk factor associated with late-onset Alzheimer’s disease (AD). To address the underlying mechanism, we develop cerebral organoid models using induced pluripotent stem cells (iPSCs...
-
Article
Open AccessSynthesis and preliminary assessment of the anticancer and Wnt/β-catenin inhibitory activity of small amide libraries of fenamates and profens
As part of an ongoing program to study the anticancer activity of non-steroidal anti-inflammatory drugs (NSAIDs) through generating diversity libraries of multiple NSAID scaffolds, we synthesized a series of N...
-
Article
On the use of mathematically-derived traits in QTL map**
Mathematically-derived traits from two or more component traits, either by addition, subtraction, multiplication, or division, have been frequently used in genetics and breeding. When used in quantitative trai...
-
Chapter and Conference Paper
A Base Station-Coordinated Contention Resolution for IEEE 802.16 PMP Networks
IEEE 802.16 PMP mode recommends using truncated Binary Exponential Backoff (BEB) algorithm to resolve the contention when multiple Subscriber Stations (SSs) compete for the connection and resource allocation f...
-
Chapter and Conference Paper
Backtracking Based Handoff Rerouting Algorithm for WiMAX Mesh Mode
Reconstruct a new route for network services during the handoff process is a fundamental issue of wireless communication. This paper proposes a new rerouting algorithm to achieve a fast handoff based on k-hop bac...
-
Article
LRP6 expression promotes cancer cell proliferation and tumorigenesis by altering β-catenin subcellular distribution
The Wnt signaling pathway plays key roles in both embryogenesis and tumorigenesis. The low-density lipoprotein (LDL) receptor-related protein-6 (LRP6), a novel member of the expanding LDL receptor family, func...
