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Article
Association of birthweight and risk of incident dementia: a prospective cohort study
Given the epidemiological studies investigating the relationship between birthweight and dementia are limited. Our study aimed to explore the association between birthweight and the risk of dementia, cognitive...
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Article
Synthesis of nanosheet SSZ-39 zeolite with enhanced catalytic performance in methanol-to-olefins reaction
In order to improve the mass transfer rate of SSZ-39 and prolong its catalytic lifetime, peculiar nanosheet SSZ-39 zeolites were prepared by hydrothermal synthesis using N,N-dimethyl-3,5-dimethylpiperidinium as a...
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Article
Open AccessEfficacy and safety of tislelizumab plus bacillus-calmette guérin with or without chemotherapy as a bladder-sparing treatment for high-risk non-muscle-invasive bladder urothelial cancer: a real-world study
Despite adequate transurethral resection of the bladder tumor (TURBT) followed by intravesical bacillus-calmette guérin (BCG), high-risk non-muscle-invasive bladder cancer (HR-NMIBC) is associated with high ra...
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Article
Open AccessChikusetsu Saponin IVa liposomes modified with a retro-enantio peptide penetrating the blood-brain barrier to suppress pyroptosis in acute ischemic stroke rats
The therapeutic strategies for acute ischemic stroke were faced with substantial constraints, emphasizing the necessity to safeguard neuronal cells during cerebral ischemia to reduce neurological impairments a...
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Article
Characterizing the post-traumatic growth trajectory in gastric cancer survivors: a population-based longitudinal study
Post-traumatic growth can improve the quality of life of cancer survivors. The objective of this study was to investigate post-traumatic growth heterogeneity trajectory in perioperative gastric cancer survivor...
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Article
RIP3 orchestrates oxidative stress and pyroptosis in doxorubicin-induced cardiotoxicity through regulation of AKT/Nrf2 signaling cascade
This study was designed to explore the role of RIP3 in DOX-induced cardiotoxicity and its underlying molecular mechanisms. Our results demonstrate that RIP3 exacerbates DOX-induced cardiotoxicity through promo...
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Article
The realization of CRISPR gene therapy
The inaugural CRISPR-based drug Casgevy has been approved by several medical agencies, with other CRISPR-based therapies currently in clinical trials. Although there are technological hurdles to overcome, chem...
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Article
Applying Latent Variable Models to Estimate Cumulative Exposure Burden to Chemical Mixtures and Identify Latent Exposure Subgroups: A Critical Review and Future Directions
Environmental mixtures, which reflect joint exposure to multiple environmental agents, are a major focus of environmental health and risk assessment research. Advancements in latent variable modeling and psych...
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Article
Open AccessAlterations of the bile microbiome is associated with progression-free survival in pancreatic ductal adenocarcinoma patients
Patients with pancreatic ductal adenocarcinoma (PDAC) display an altered oral, gastrointestinal, and intra-pancreatic microbiome compared to healthy individuals. However, knowledge regarding the bile microbiom...
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Article
Open AccessA feasibility study of in vivo quantitative ultra-short echo time-MRI for detecting early cartilage degeneration
To explore the feasibility of Ultra-short echo time (UTE) – MRI quantitative imaging in detecting early cartilage degeneration in vivo and underlying pathological and biochemical basis.
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Article
Open AccessArtistic heritage conservation: the relevance and cultural value of Guangzhou clan building paintings to traditional rituals from a kinship perspective through perceptual assessment and data mining
The study of clan paintings reveals a shift in perspective from art aesthetics to cultural connotations to cultural identity, yet literature seldom discusses the relationship between art and kinship culture. T...
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Article
Open AccessAdvances in spatial transcriptomics and its applications in cancer research
Malignant tumors have increasing morbidity and high mortality, and their occurrence and development is a complicate process. The development of sequencing technologies enabled us to gain a better understanding...
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Article
Open AccessElectrical impedance tomography provides information of brain injury during total aortic arch replacement through its correlation with relative difference of neurological biomarkers
Postoperative neurological dysfunction (PND) is one of the most common complications after a total aortic arch replacement (TAAR). Electrical impedance tomography (EIT) monitoring of cerebral hypoxia injury du...
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Article
Open AccessThe circular RNA hsa_circ_0045800 serves as a favorable biomarker in pathogenesis of sjögren's syndrome
Circular RNAs (circRNAs) play various roles in the development of many autoimmune diseases. However, their expression profiles and specific function in Sjögren's Syndrome remains largely unknown.
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Article
Open AccessSCG5 and MITF may be novel markers of copper metabolism immunorelevance in Alzheimer’s disease
The slow-develo** neurological disorder Alzheimer’s disease (AD) has no recognized etiology. A bioinformatics investigation verified copper metabolism indicators for AD development. GEO contributed AD-relate...
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Article
Open AccessFactors influencing senior care and living preferences among older adults in Jiangsu, China: a cross-sectional survey study
As the population ages, senior care for older adults in China has become increasingly important and has attracted the attention of both government and society. This study aimed to explore preferences and influ...
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Article
Open AccessEarly Hydrogen–Oxygen Gas Mixture Inhalation in Patients with Aneurysmal Subarachnoid Hemorrhage (HOMA): study protocol for a randomized controlled trial
Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening neurosurgical emergency with a high mortality rate. Delayed cerebral ischemia (DCI) and cerebral vasospasm (CVS) are delayed products of early br...
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Article
Synthesis of LSX Using Seed-iteration Approach with High N2 Adsorption Capacity for Air Separation
A series of low silica X zeolites (LSX) was synthesized through a seed-iteration approach, based on the seed addition strategy, and then loaded with lithium ions by an ion exchanging method to obtain high N2 adso...
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Article
Open AccessPotential prognostic value of CSF-targeted proteomics across the Alzheimer’s disease continuum
Core biomarkers for Alzheimer’s disease (AD), such as Aβ42 and tau, have demonstrated high prognostic accuracy but do not fully capture the complex pathophysiology of AD. In this study, our objective was to id...
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Article
Temperature-switch-based light-responsive smart hydrogel for reversible message encryption and decryption
The use of stimulus-responsive hydrogels in intelligent gel anti-counterfeiting systems is a promising method to encrypt and decrypt information. External stimuli such as light, heat, electricity, magnetism an...
