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  1. Article

    Open Access

    Early Hydrogen–Oxygen Gas Mixture Inhalation in Patients with Aneurysmal Subarachnoid Hemorrhage (HOMA): study protocol for a randomized controlled trial

    Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening neurosurgical emergency with a high mortality rate. Delayed cerebral ischemia (DCI) and cerebral vasospasm (CVS) are delayed products of early br...

    Fa Lin, Runting Li, Yu Chen, Jun Yang, Ke Wang, Yitong Jia, Heze Han, Qiang Hao… in Trials (2024)

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  2. No Access

    Article

    Laser interstitial thermal therapy for recurrent glioblastomas: a systematic review and meta-analysis

    We aim to investigate the efficacy and safety of laser interstitial thermal therapy (LITT) in treating recurrent glioblastomas (rGBMs). A comprehensive search was conducted in four databases to identify studie...

    Xuzhe Zhao, Runting Li, Yiding Guo, Haibin Wan, Dabiao Zhou in Neurosurgical Review (2024)

  3. Article

    Correction to: Comparison of Long‑Term Outcomes in Ruptured Diffuse Brain Arteriovenous Malformations Between Interventional Therapy and Conservative Management

    Changyu Lu, Heze Han, Li Ma, Ruinan Li, Zhipeng Li… in Translational Stroke Research (2024)

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  4. No Access

    Article

    Recurrence of Cerebral Arteriovenous Malformation Following Complete Obliteration Through Endovascular Embolization

    Arteriovenous malformation (AVM) recurrence after embolization was rarely reported. This study aimed to explore the potential risk factors of recurrence in angiographically obliterated AVMs treated with endova...

    Qiang Hao, Haibin Zhang, Heze Han, Hengwei **, Li Ma… in Translational Stroke Research (2023)

  5. No Access

    Article

    Comparison of Long-Term Outcomes in Ruptured Diffuse Brain Arteriovenous Malformations Between Interventional Therapy and Conservative Management

    Brain arteriovenous malformations (AVMs) with a diffuse nidus structure present a therapeutic challenge due to their complexity and elevated risk of hemorrhagic events. This study examines the long-term effect...

    Changyu Lu, Heze Han, Li Ma, Ruinan Li, Zhipeng Li… in Translational Stroke Research (2023)

  6. No Access

    Article

    A 90-Day Prognostic Model Based on the Early Brain Injury Indicators after Aneurysmal Subarachnoid Hemorrhage: the TAPS Score

    This study aimed to establish a new scoring model based on the early brain injury (EBI) indicators to predict the 90-day functional outcomes in patients with aneurysmal subarachnoid hemorrhage (aSAH). We retro...

    Runting Li, Fa Lin, Yu Chen, Junlin Lu, Heze Han, Li Ma… in Translational Stroke Research (2023)

  7. Article

    Open Access

    Multimodality treatment for brain arteriovenous malformation in Mainland China: design, rationale, and baseline patient characteristics of a nationwide multicenter prospective registry

    Brain arteriovenous malformation (AVM) is an important cause of hemorrhagic stroke in young adults, which can lead to severe neurological impairment. The registry of Multimodality treatment for brain ArTeriove...

    Yu Chen, Heze Han, Li Ma, Ruinan Li, Zhipeng Li, Debin Yan… in Chinese Neurosurgical Journal (2022)

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  8. No Access

    Article

    The effect of sex differences on complications and 90-day outcomes after aneurysmal subarachnoid hemorrhage: a propensity score-matched analysis

    Aneurysmal subarachnoid hemorrhage (aSAH) is the most devastating form of stroke. Up to now, little is known about the effect of sex differences on complications and outcomes. We retrospectively reviewed aSAH ...

    Runting Li, Fa Lin, Yu Chen, Junlin Lu, Jun Yang, Heze Han… in Neurosurgical Review (2022)

  9. No Access

    Article

    mTOR-FABP4 signal is activated in brain arteriovenous malformations in humans

    Arteriovenous malformations (AVMs) are the most common types of cerebral vascular malformations, which are dynamic lesions with de novo growth potentials. The dysfunction of endothelial cells has been postulat...

    Debin Yan, Qiang Hao, Yu Chen, Zhipeng Li, Haibin Zhang… in Journal of Molecular Medicine (2022)

  10. No Access

    Article

    Elevated blood hemoglobin on admission as an independent predictor of unfavorable outcomes in patients with aneurysmal subarachnoid hemorrhage

    Hemoglobin (HGB), a potent spasmogen, may cause irreversible damage to the brain after aneurysm rupture. However, there is no clinical evidence to reveal the relationship between blood HGB concentrations on a...

    Runting Li, Fa Lin, Yu Chen, Junlin Lu, Heze Han, Li Ma, Yahui Zhao… in Neurosurgical Review (2022)

  11. No Access

    Article

    The value of early CT perfusion parameters for predicting delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis

    Delayed cerebral ischemia (DCI) is a devastating complication of aneurysmal subarachnoid hemorrhage (aSAH). We aim to investigate the efficacy of early CT perfusion (CTP) parameters for predicting DCI in patie...

    Heze Han, Yu Chen, Runting Li, Fa Lin, Junlin Lu, **aolin Chen… in Neurosurgical Review (2022)

  12. No Access

    Article

    Dioscorea deltoidea Leaf Extract (DDLE) Targets PI3K/AKT/mTOR Pathway and Inhibits Ovarian Cancer Cell Growth

    Ovarian cancer is the malignant tumour of the female reproductive organ with highest mortality rate among all the types of gynaecological tumours. This study investigated the effect of Dioscorea deltoidea leaf ex...

    Ying Jiao, Ying **ong, Lin He, Zhifeng Yang… in Doklady Biochemistry and Biophysics (2021)

  13. No Access

    Article

    Docosahexaenoic Acid (DHA) Supplementation Alters Phospholipid Species and Lipid Peroxidation Products in Adult Mouse Brain, Heart, and Plasma

    The abundance of docosahexaenoic acid (DHA) in phospholipids in the brain and retina has generated interest to search for its role in mediating neurological functions. Besides the source of many oxylipins with...

    Grace Y. Sun, Michael K. Appenteng, Runting Li, Taeseon Woo… in NeuroMolecular Medicine (2021)

  14. No Access

    Article

    Harpagophytum procumbens Extract Ameliorates Allodynia and Modulates Oxidative and Antioxidant Stress Pathways in a Rat Model of Spinal Cord Injury

    Spinal cord injury (SCI) is a deliberating disorder with impairments in locomotor deficits and incapacitating sensory abnormalities. Harpagophytum procumbens (Hp) is a botanical widely used for treating inflammat...

    Garrett Ungerer, Jiankun Cui, Tina Ndam, Mikeala Bekemeier… in NeuroMolecular Medicine (2020)

  15. No Access

    Article

    Effects of Docosahexaenoic Acid and Its Peroxidation Product on Amyloid-β Peptide-Stimulated Microglia

    Growing evidence suggests that docosahexaenoic acid (DHA) exerts neuroprotective effects, although the mechanism(s) underlying these beneficial effects are not fully understood. Here we demonstrate that DHA, b...

    Xue Geng, Bo Yang, Runting Li, Tao Teng, Mary Jo Ladu… in Molecular Neurobiology (2020)

  16. No Access

    Article

    Human Papillomavirus 16 oncoprotein E7 retards mitotic progression by blocking Mps1-MAP4 signaling cascade

    Human epithelial cells can be infected by more than 200 types of human papilloma viruses (HPVs), and persistent HPV infections lead to cervical cancer or other deadly cancers. It has been established that mito...

    Yu Guo, **aojuan Zhang, Quanbin Xu, Fuxing Gong, **aoqian Shi, Chaokun Li… in Oncogene (2019)

  17. Article

    Open Access

    Unveiling anti-oxidative and anti-inflammatory effects of docosahexaenoic acid and its lipid peroxidation product on lipopolysaccharide-stimulated BV-2 microglial cells

    Phospholipids in the central nervous system are enriched in n-3 and n-6 polyunsaturated fatty acids (PUFA), especially docosahexaenoic acid (DHA) and arachidonic acid (ARA). These PUFA can undergo enzymatic re...

    Bo Yang, Runting Li, C. Michael Greenlief… in Journal of Neuroinflammation (2018)

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  18. No Access

    Article

    Withania somnifera and Its Withanolides Attenuate Oxidative and Inflammatory Responses and Up-Regulate Antioxidant Responses in BV-2 Microglial Cells

    Withania somnifera (L.) Dunal, commonly known as Ashwagandha, has been used in Ayurvedic medicine for promoting health and quality of life. Recent clinical trials together with experiment...

    Grace Y. Sun, Runting Li, Jiankun Cui, Mark Hannink, Zezong Gu… in NeuroMolecular Medicine (2016)