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Article
Open AccessRIP3 is an upregulator of aerobic metabolism and the enhanced respiration by necrosomal RIP3 feeds back on necrosome to promote necroptosis
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Article
Open AccessYL064 directly inhibits STAT3 activity to induce apoptosis of multiple myeloma cells
Aberrant activation of signal transducer and activator of transcription 3 (STAT3) plays a critical role in the proliferation and survival of multiple myeloma. And inactivation of STAT3 is considered a promisin...
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Article
Open AccessLncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia/reperfusion injury
Ischemia-reperfusion (I/R) is a common pathology when the blood supply to an organ was disrupted and then restored. During the reperfusion process, inflammation and tissue injury were triggered, which were med...
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Article
Open AccessFate decision of satellite cell differentiation and self-renewal by miR-31-IL34 axis
Quiescent satellite cells (SCs) that are activated to produce numerous myoblasts underpin the complete healing of damaged skeletal muscle. How cell-autonomous regulatory mechanisms modulate the balance among c...
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Article
Open AccessFecal microbiota transplantation from patients with autoimmune encephalitis modulates Th17 response and relevant behaviors in mice
The significance of the microbiota-gut-brain axis has been increasingly recognized as a major modulator of autoimmunity. Here, we aim to characterize the gut microbiota of a large cohort of treatment-naïve anti-N
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Open AccessLncRNA ZNF674-AS1 regulates granulosa cell glycolysis and proliferation by interacting with ALDOA
Granulosa cell (GC) is a critical somatic component of ovarian follicles to support oocyte development, while the regulatory role of long noncoding RNA (lncRNA) in GCs is largely unknown. Here, we identified a...
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Open AccessDownregulated developmental processes in the postnatal right ventricle under the influence of a volume overload
The molecular atlas of postnatal mouse ventricular development has been made available and cardiac regeneration is documented to be a downregulated process. The right ventricle (RV) differs from the left ventr...
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Article
The long non-coding RNA PFI protects against pulmonary fibrosis by interacting with splicing regulator SRSF1
Pulmonary fibrosis (PF) is a type of interstitial pneumonia with complex etiology and high mortality, characterized by progressive scarring of the alveolar interstitium and myofibroblastic lesions. Recently, t...
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Article
Arginine methyltransferase PRMT5 methylates and stabilizes KLF5 via decreasing its phosphorylation and ubiquitination to promote basal-like breast cancer
Krüppel-like factor 5 (KLF5) is an oncogenic factor that is highly expressed in basal-like breast cancer (BLBC) and promotes cell proliferation, survival, migration, stemness, and tumor growth; however, its po...
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Open AccessICA69 aggravates ferroptosis causing septic cardiac dysfunction via STING trafficking
Previous studies have demonstrated that cardiomyocyte apoptosis, ferroptosis, and inflammation participate in the progress of sepsis-induced cardiomyopathy (SIC). Although Islet cell autoantigen 69 (ICA69) is ...
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Open AccessSilencing of lncRNA MALAT1 facilitates erastin-induced ferroptosis in endometriosis through miR-145-5p/MUC1 signaling
Endometriosis is a chronic disorder characterized by the implantation of endometrial glands and stroma outside the uterus. However, the pathogenesis of endometriosis is still unclear. To date, there is no full...
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Article
YB-1 is a positive regulator of KLF5 transcription factor in basal-like breast cancer
Y-box binding protein 1 (YB-1) is a well-known oncogene highly expressed in various cancers, including basal-like breast cancer (BLBC). Beyond its role as a transcription factor, YB-1 is newly defined as an ep...
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Open AccessGankyrin modulated non-small cell lung cancer progression via glycolysis metabolism in a YAP1-dependent manner
Non-small cell lung cancer (NSCLC) is highly malignant and heterogeneous form of lung cancer and involves various oncogene alterations. Glycolysis, an important step in tumor metabolism, is closely related to ...
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Open AccessRBM47 inhibits hepatocellular carcinoma progression by targeting UPF1 as a DNA/RNA regulator
The mechanisms by which the tumor behaviors of hepatocellular carcinoma (HCC) support growth and metastasis remain largely unknown, and it has become increasingly apparent that molecular dysregulation is of co...
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Article
Open AccessHuman-specific gene CT47 blocks PRMT5 degradation to lead to meiosis arrest
Exploring the functions of human-specific genes (HSGs) is challenging due to the lack of a tractable genetic model system. Testosterone is essential for maintaining human spermatogenesis and fertility, but the...
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Article
Open AccessNSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress
Doxorubicin (DOX) is a commonly used antitumor drug, but its application has been limited because of its strong cardiac damage. This study aims to explore the role of NSUN2 in DOX-induced heart injury. C57BL/6...
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Open AccessCorrection to: LncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia/reperfusion injury
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Open AccessJMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a chronic disorder characterized by hyperproliferation of pulmonary arterial smooth muscle cells (PASMCs). JMJD1C, a member of the Jumonji domain containing C (JMJC) hi...
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Open AccessCorrection to: NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress
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Histone demethylase KDM5B licenses macrophage-mediated inflammatory responses by repressing Nfkbia transcription
Macrophages play a critical role in the immune homeostasis and host defense against invading pathogens. However, uncontrolled activation of inflammatory macrophages leads to tissue injury and even fuels autoim...