25 Result(s)
within
YingKai **ao
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessAn fNIRS dataset for driving risk cognition of passengers in highly automated driving scenarios
For highly autonomous vehicles, human does not need to operate continuously vehicles. The brain-computer interface system in autonomous vehicles will highly depend on the brain states of passengers rather than...
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Open AccessDynamics underlie the drug recognition mechanism by the efflux transporter EmrE
The multidrug efflux transporter EmrE from Escherichia coli requires anionic residues in the substrate binding pocket for coupling drug transport with the proton motive force. Here, we show how protonation of a s...
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Open AccessOnline legal driving behavior monitoring for self-driving vehicles
Defined traffic laws must be respected by all vehicles when driving on the road, including self-driving vehicles without human drivers. Nevertheless, the ambiguity of human-oriented traffic laws, particularly ...
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Open AccessSouthern Tibetan rifting since late Miocene enabled by basal shear of the underthrusting Indian lithosphere
Syncontractional extension is prominent in present-day Tibet, but its origin remains vigorously debated. Several deep-seated geodynamic processes (e.g., Indian underthrusting, horizontal flow, and mantle upwel...
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Open AccessDeep sequencing of microRNAs reveals circadian-dependent microRNA expression in the eyestalks of the Chinese mitten crab Eriocheir sinensis
MicroRNAs (miRNAs) are small endogenous non-coding RNAs. In crustaceans, miRNAs might be involved in the regulation of circadian rhythms. Many physiological functions of crustaceans including immunity and horm...
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Open AccessIntestinal bacterial community composition of juvenile Chinese mitten crab Eriocheir sinensis under different feeding times in lab conditions
Feeding time is an important factor affecting the physiological activity and feeding rhythm of crustaceans. However, little is known about the factors and mechanisms contributing to variations in feeding time ...
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Open AccessSelective and noncovalent targeting of RAS mutants for inhibition and degradation
Activating mutants of RAS are commonly found in human cancers, but to date selective targeting of RAS in the clinic has been limited to KRAS(G12C) through covalent inhibitors. Here, we report a monobody, termed 1...
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Open AccessDominant role of CDKN2B/p15INK4B of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis
Human chromosome 9p21.3 is susceptible to inactivation in cell immortalization and diseases, such as cancer, coronary artery disease and type-2 diabetes. Although this locus encodes three cyclin-dependent kina...
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Article
Open AccessEGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction
Epigallocatechin gallate (EGCG) from green tea can induce apoptosis in cancerous cells, but the underlying molecular mechanisms remain poorly understood. Using SPR and NMR, here we report a direct, μM interact...
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Article
Open AccessModulation of virus-induced NF-κB signaling by NEMO coiled coil mimics
Protein-protein interactions featuring intricate binding epitopes remain challenging targets for synthetic inhibitors. Interactions of NEMO, a scaffolding protein central to NF-κB signaling, exemplify this cha...
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Open AccessOncopig Soft-Tissue Sarcomas Recapitulate Key Transcriptional Features of Human Sarcomas
Human soft-tissue sarcomas (STS) are rare mesenchymal tumors with a 5-year survival rate of 50%, highlighting the need for further STS research. Research has been hampered by limited human sarcoma cell line av...
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Open AccessResveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation
Resveratrol is a natural compound found in red wine that has been suggested to exert its potential health benefit through the activation of SIRT1, a crucial member of the mammalian NAD+-dependent deacetylases. SI...
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Article
Open AccessA quantum approach to homomorphic encryption
Encryption schemes often derive their power from the properties of the underlying algebra on the symbols used. Inspired by group theoretic tools, we use the centralizer of a subgroup of operations to present a...
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Article
Open AccessGiant Two-photon Absorption in Circular Graphene Quantum Dots in Infrared Region
We investigate theoretically the two-photon absorption (TPA) for circular graphene quantum dots (GQDs) with the edge of armchair and zigzag on the basis of electronic energy states obtained by solving the Dira...
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Open AccessDirect observation of a Fermi liquid-like normal state in an iron-pnictide superconductor
There are two prerequisites for understanding high-temperature (high-Tc) superconductivity: identifying the pairing interaction and obtaining a correct description of the normal state from which superconductivity...
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Alterations in cecal microbiota of **hua piglets fostered by a Yorkshire sow
Gut microbiota play important roles in host health and diseases. Several factors, in particular antibiotics, affect the gut microbiota of pigs. Cross-fostering has been applied as a regular practice to equaliz...
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Article
An atlas of DNA methylomes in porcine adipose and muscle tissues
It is evident that epigenetic factors, especially DNA methylation, have essential roles in obesity development. Here, using pig as a model, we investigate the systematic association between DNA methylation and...
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Open AccessStable isotope fractionation of chlorine during evaporation of brine from a saline lake
Brine from the saline Qarhan Lake was evaporated at 28±2°C in a clean environment. Two groups of experiments were conducted; one with complete separation of precipitate and brine at different stages of evapora...
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In situ boron isotope measurements of natural geological materials by LA-MC-ICP-MS
There are two main methods to determine boron isotopic composition. One is the solution method, in which boron is purified after the samples are dissolved in solution and the boron isotope ratios are determine...
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Strontium and boron isotopic constraint on the marine origin of the Khammuane potash deposits in southeastern Laos
Since 2006, we have conducted a geological exploration of the Khammuane area in southeastern Laos. Several thick sequences of potash deposits containing sylvite and carnallite were discovered from drilling Pal...
