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Article
Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer
Metastasis occurs frequently after resection of pancreatic cancer (PaC). In this study, we hypothesized that multi-parametric analysis of pre-metastatic liver biopsies would classify patients according to thei...
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Article
Open AccessTargeting pancreatic cancer metabolic dependencies through glutamine antagonism
Pancreatic ductal adenocarcinoma (PDAC) cells use glutamine (Gln) to support proliferation and redox balance. Early attempts to inhibit Gln metabolism using glutaminase inhibitors resulted in rapid metabolic r...
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Article
Open AccessAuthor Correction: Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment
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Article
Open AccessSingle-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment
The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) is a complex ecosystem that drives tumor progression; however, in-depth single cell characterization of the PDAC TME and its role in ...
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Article
Open AccessImpact of changing guidelines on genetic testing and surveillance recommendations in a contemporary cohort of breast cancer survivors with family history of pancreatic cancer
Changing practice guidelines and recommendations have important implications for cancer survivors. This study investigated genetic testing patterns and outcomes and reported family history of pancreatic cancer...
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Article
A novel target for combination immunotherapy in pancreatic cancer: IL-1β mediates immunosuppression in the tumour microenvironment
Immune checkpoint blockade (ICB) has demonstrated efficacy in multiple cancers, offering the potential of long-term disease control not achievable with cytotoxic or targeted therapies. However, the field has n...
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Article
Open AccessDominant role of CDKN2B/p15INK4B of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis
Human chromosome 9p21.3 is susceptible to inactivation in cell immortalization and diseases, such as cancer, coronary artery disease and type-2 diabetes. Although this locus encodes three cyclin-dependent kina...
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Article
Author Correction: Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas
A Correction to this paper has been published: https://doi.org/10.1038/s41587-019-0392-8.
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Article
Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas
Single-cell RNA sequencing (scRNA-seq) enables the systematic identification of cell populations in a tissue, but characterizing their spatial organization remains challenging. We combine a microarray-based sp...
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Article
Open AccessNew Labyrinth Microfluidic Device Detects Circulating Tumor Cells Expressing Cancer Stem Cell Marker and Circulating Tumor Microemboli in Hepatocellular Carcinoma
Hepatocellular Carcinoma (HCC) is one of the most lethal cancers with a high mortality and recurrence rate. Circulating tumor cell (CTC) detection offers various opportunities to advance early detection and mo...
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Article
ATDC mediates a TP63-regulated basal cancer invasive program
Basal subtype cancers are deadly malignancies but the molecular events driving tumor lethality are not completely understood. Ataxia-telangiectasia group D complementing gene (ATDC, also known as TRIM29), is high...
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Protocol
Pancreatic Microtumors: A Novel 3D Ex Vivo Testing Platform
The tumor microenvironment plays a vital role in therapeutic resistance in pancreatic adenocarcinoma. We have created a 3D model to study the tumor microenvironment ex vivo that integrates tumor cells with tum...
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Reference Work Entry In depth
Pancreatic Cancer Stem Cells
Cancer stem cells (CSCs) are a distinct subpopulation of cells within a tumor that are capable of self-renewal and producing differentiated progeny. These cells appear to be more resilient to treatment than bu...
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Reference Work Entry In depth
Pancreatic Cancer Stem Cells
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Article
A phase I trial of cabozantinib and gemcitabine in advanced pancreatic cancer
Background Cabozantinib and gemcitabine improve tumor control in pancreatic ductal adenocarcinoma (PDAC) in preclinical models through c-Met inhibition. We sought to determine the maximum...
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Living Reference Work Entry In depth
Pancreatic Cancer Stem Cells
Cancer stem cells (CSCs) are a distinct subpopulation of cells within a tumor that are capable of self-renewal and producing differentiated progeny. These cells appear to be more resilient to treatment than bu...
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Living Reference Work Entry In depth
Pancreatic Cancer Stem Cells
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Article
Erratum: Sensitive capture of circulating tumour cells by functionalized graphene oxide nanosheets
Nature Nanotechnology 8, 735–741 (2013); published online 29 September 2013; corrected after print 1 October 2013. In the version of this Letter originally published, in Fig. 1b one of the PEG chains was mispl...
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Article
Sensitive capture of circulating tumour cells by functionalized graphene oxide nanosheets
The spread of cancer throughout the body is driven by circulating tumour cells (CTCs)1. These cells detach from the primary tumour and move from the bloodstream to a new site of subsequent tumour growth. They als...
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Article
Breast Cancer Metastases to the Pancreas
The pancreas can serve as the destination for metastatic spread of malignancies from multiple organ sites. Breast cancer metastases to the pancreas are part of this spectrum and surgeons evaluate such patients...
