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Article
Open AccessThe causal relationship between anti-diabetic drugs and gastrointestinal disorders: a drug-targeted mendelian randomization study
The incidence of diabetic gastrointestinal diseases is increasing year by year. This study aimed to investigate the causal relationship between antidiabetic medications and gastrointestinal disorders, with the...
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Article
Time of exercise differentially impacts bone growth in mice
Although physical training has been shown to improve bone mass, the time of day to exercise for optimal bone growth remains uncertain. Here we show that engaging in physical activity during the early active ph...
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Article
Open AccessStrategies for improving fengycin production: a review
Fengycin is an important member of the lipopeptide family with a wide range of applications in the agricultural, food, medical and cosmetic industries. However, its commercial applicatio...
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Article
Open AccessThe landscape of transcriptional profiles in human oocytes with different chromatin configurations
With increasingly used assisted reproductive technology (ART), the acquisition of high-quality oocytes and early embryos has become the focus of much attention. Studies in mice have found that the transition o...
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Article
Open AccessEffects of task-based mirror therapy on upper limb motor function in hemiplegia: study protocol for a randomized controlled clinical trial
Research to date has lacked definitive evidence to determine whether mirror therapy promotes the recovery of upper extremity function after stroke. Considering that previous studies did not stratify patients b...
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Article
Open Accessp53/E2F7 axis promotes temozolomide chemoresistance in glioblastoma multiforme
Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer, and chemoresistance poses a significant challenge to the survival and prognosis of GBM. Although numerous regulatory mechanisms that c...
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Article
Antiviral drug recognition and elevator-type transport motions of CNT3
Nucleoside analogs have broad clinical utility as antiviral drugs. Key to their systemic distribution and cellular entry are human nucleoside transporters. Here, we establish that the human concentrative nucle...
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Article
Open AccessThe osteoclastic activity in apical distal region of molar mesial roots affects orthodontic tooth movement and root resorption in rats
The utilization of optimal orthodontic force is crucial to prevent undesirable side effects and ensure efficient tooth movement during orthodontic treatment. However, the sensitivity of existing detection tech...
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Article
Low-Dose LPS Modulates Microglia/Macrophages Phenotypic Transformation to Amplify Rehabilitation Effects in Chronic Spinal Cord Injured (CSCI) Mice
Spinal cord injury (SCI) results in stalled motor function recovery under the chronic phase. One of the reasons due to the presence of ongoing inflammation. Therefore, regulating the status of immune cells may...
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Article
Open AccessSurgery combined with adjuvant radiation and chemotherapy prolonged overall survival in stage IVC anaplastic thyroid cancer: a SEER-based analysis
Anaplastic thyroid carcinoma (ATC) is a rare but aggressive malignancy, which accounts for only 1–2% of all thyroid cancers. The median overall survival (OS) time for all stages patients is at about 5 months. ...
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Article
Open AccessCrystallographic orientation dependence on nanoscale friction behavior of energetic β-HMX crystal
Tribology behaviors of energetic crystals play critical roles in the friction-induced hotspot in high-energy explosive, however, the binder and energetic crystals are not distinguished properly in previous inv...
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Article
Open AccessOsteopontin enhances the effect of treadmill training and promotes functional recovery after spinal cord injury
In this study, we examined the combined impact of osteopontin (OPN) and treadmill training on mice with spinal cord injury (SCI). OPN was overexpressed by injecting AAV9-SPP1-GFP into the sensorimotor cortex, ...
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Article
Identification of DNA variants at ultra-low variant allele frequencies via Taq polymerase cleavage of wild-specific blockers
Detecting mutations related to tumors holds immense clinical significance for cancer diagnosis and treatment. However, the presence of highly redundant wild DNA poses a challenge for the advancement of low-cop...
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Article
IGF-1 Combined with OPN Promotes Neuronal Axon Growth in Vitro Through the IGF-1R/Akt/mTOR Signaling Pathway in Lipid Rafts
This study aims to investigate the effect of insulin-like growth factor 1 (IGF-1) combined with osteopontin (OPN) on the protein expression levels and growth of neuronal axons and its possible mechanism. In th...
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Article
Future carbon storages of ecosystem based on land use change and carbon sequestration practices in a large economic belt
Assessments of ecosystem carbon storage are needed to form the scientific basis for carbon policies. Due to lack of data, there are few accurate, large-scale, and long-term predictions of ecosystem carbon stor...
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Article
Approaches to electrodeposit molybdenum from ionic liquid
Molybdenum is a kind of refractory metal and can hardly be deposited in aqueous solution since it is more likely to form molybdenum oxide rather than elementary Mo, but molten salts and ionic liquid become alt...
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Article
Divergence in the distribution of di(2-ethylhexyl) phthalate (DEHP) in two soils
Understanding the distribution of di(2-ethylhexyl) phthalate (DEHP) is necessary for future risk evaluation of DEHP in agricultural soils. This study used 14C-labeled DEHP to examine its volatilization, mineraliz...
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Article
Elevated Atmospheric CO2 Reduced Antibiotics Accumulation in Rice Grains and Soil ARGs Abundance in Multiple Antibiotics-contaminated Paddy Fields
Antibiotic resistance genes(ARGs) as new pollutants have become a global environmental pollution problem in recent years. Elevated atmospheric CO2 is one of the major factors affecting global climate change. But,...
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Article
Developmental growth plate cartilage formation suppressed by artificial light at night via inhibiting BMAL1-driven collagen hydroxylation
Exposure to artificial light at night (LAN) can induce obesity, depressive disorder and osteoporosis, but the pernicious effects of excessive LAN exposure on tissue structure are poorly understood. Here, we de...
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Elevated CO2 may increase the health risks of consuming leafy vegetables cultivated in flooded soils contaminated with Cd and Pb
Elevated CO2 levels threat the crop quality by altering the environmental behavior of heavy metals (HMs) in soils. In reality, multiple HMs often co-exist in field, while details regarding coexisting HMs migratio...
