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Article
Survival mechanisms of circulating tumor cells and their implications for cancer treatment
Metastasis remains the principal trigger for relapse and mortality across diverse cancer types. Circulating tumor cells (CTCs), which originate from the primary tumor or its metastatic sites, traverse the vasc...
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Article
Open AccessInhibition of SQSTM1 S403 phosphorylation facilitates the aggresome formation of ubiquitinated proteins during proteasome dysfunction
Ubiquitin–proteasome-system-mediated clearance of misfolded proteins is essential for cells to maintain proteostasis and reduce the proteotoxicity caused by these aberrant proteins. When proteasome activity is...
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Article
Middle Yangtze sea-basin over Paleozoic-Mesozoic transition
On the centimeter scale of lithologic change, we conduct poly-statistic analysis on the sedimentary behavior and dynamic features of the stratigraphic sequence from upper Dalong formation to lower Daye formati...
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Article
The Earth’s inner core deviation to plate movement
Under the premise of the Earth’s layer structure and mass distribution, the solid inner core cannot be stable in the center of the sphere. Thus, the deviation of the inner core is towards the sphere’s center a...
