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Article
Open AccessQuantification of localized NAD+ changes reveals unique specificity of NAD+ regulation in the hypothalamus
Recently, it has become a consensus that systemic decreases in NAD+ are a critical trigger for age-associated functional decline in multiple tissues and organs. The hypothalamus, which contains several functional...
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Article
Open AccessRibonucleotide reductase M2B in the myofibers modulates stem cell fate in skeletal muscle
The balance among quiescence, differentiation, and self-renewal of skeletal muscle stem cells (MuSCs) is tightly regulated by their intrinsic and extrinsic properties from the niche. How the niche controls MuS...
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Article
Open AccessModulation of sensorimotor cortical oscillations in athletes with yips
The yips, an involuntary movement impediment that affects performance in skilled athletes, is commonly described as a form of task-specific focal dystonia or as a disorder lying on a continuum with focal dysto...
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Article
Open AccessThe ubiquitin–proteasome system in regulation of the skeletal muscle homeostasis and atrophy: from basic science to disorders
Skeletal muscle is one of the most abundant and highly plastic tissues. The ubiquitin–proteasome system (UPS) is recognised as a major intracellular protein degradation system, and its function is important fo...
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Article
Open AccessMetabolomic Analysis of Skeletal Muscle in Aged Mice
Sarcopenia is the age-induced, progressive loss of skeletal muscle mass and function. To better understand changes in skeletal muscle during sarcopenia, we performed a metabolomic analysis of skeletal muscle i...
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Article
Open AccessHistone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration
Regulation of gene expression requires selective incorporation of histone H3 variant H3.3 into chromatin. Histone H3.3 has several subsidiary variants but their functions are unclear. Here we characterize the ...
