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  1. Article

    Open Access

    Common dietary emulsifiers promote metabolic disorders and intestinal microbiota dysbiosis in mice

    Dietary emulsifiers are linked to various diseases. The recent discovery of the role of gut microbiota–host interactions on health and disease warrants the safety reassessment of dietary emulsifiers through th...

    Suraphan Panyod, Wei-Kai Wu, Chih-Ting Chang, Naohisa Wada in Communications Biology (2024)

  2. No Access

    Chapter and Conference Paper

    Face-Milling Cutting Simulation of Bevel Gears Using Ring-Dexel Method

    Face milling is primarily used for producing spiral bevel and hypoid gears. Over the past few decades, this cutting method has been implemented on five-axis CNC machine tools with a cutting path that has five ...

    Yi-Pei Shih, Bor-Tyng Sheen, Chuan-Feng Ting in Advances in Mechanism and Machine Science (2024)

  3. No Access

    Article

    Co-printing of micro/nanostructures integrated with preconcentration to enhance protein detection

    This paper reports a fabrication method that can make microstructures such as microfluidic channels and nanostructures to generate surface plasmon resonance (SPR) signals in one-step using hot embossing. We fi...

    Yi-Jung Lu, Han-Yun Hsieh, Wen-Fai Yang, Kuang-Chong Wu in Microfluidics and Nanofluidics (2023)

  4. Article

    Open Access

    Ginger essential oil and citral ameliorates atherosclerosis in ApoE−/− mice by modulating trimethylamine-N-oxide and gut microbiota

    Recently, the role of the gut microbiota in diseases, including cardiovascular disease (CVD), has gained considerable research attention. Trimethylamine-N-oxide (TMAO), which is formed during ʟ-carnitine metab...

    Suraphan Panyod, Wei-Kai Wu, Sin-Yi Peng, Yea-**g Tseng in npj Science of Food (2023)

  5. Article

    Correction: Comparing Predictability of Non‑invasive Tools for Hepatocellular Carcinoma in Treated Chronic Hepatitis C Patients

    Yen-Chun Liu, Ya-Ting Cheng, Yi-Cheng Chen in Digestive Diseases and Sciences (2023)

  6. No Access

    Article

    Comparing Predictability of Non-invasive Tools for Hepatocellular Carcinoma in Treated Chronic Hepatitis C Patients

    Non-invasive tools including liver stiffness measurement (LSM) or FIB-4, assessed before or after direct acting antivirals (DAA), have been suggested to predict hepatocellular carcinoma (HCC).

    Yen-Chun Liu, Ya-Ting Cheng, Yi-Cheng Chen in Digestive Diseases and Sciences (2023)

  7. Article

    Open Access

    Impact of chronic hepatitis on cardiovascular events among type 2 diabetes patients in Taiwan pay-for-performance program

    To investigate the impact of chronic hepatitis on cardiovascular events in patients with type 2 diabetes mellitus (T2DM). This nationwide retrospective cohort study included 152,709 adult patients (> 20 years)...

    Yi-**g Sheen, Chih-Cheng Hsu, Pei-Tseng Kung, Li-Ting Chiu in Scientific Reports (2022)

  8. Article

    Open Access

    Risk factors of recurrence and distant metastasis in primary cutaneous melanoma in Taiwan

    Risk factors of recurrence and distant metastasis of acral lentiginous melanoma (ALM) are of great interest for the high percentage of ALM in cutaneous melanoma in Asian populations. This single-center retrosp...

    Tung-Lin Lee, Yi-Hua Liao, Jau-Yu Liau, Yi-Shuan Sheen in Scientific Reports (2021)

  9. Article

    Open Access

    Characterization of TMAO productivity from carnitine challenge facilitates personalized nutrition and microbiome signatures discovery

    The capability of gut microbiota in degrading foods and drugs administered orally can result in diversified efficacies and toxicity interpersonally and cause significant impact on human health. Production of a...

    Wei-Kai Wu, Suraphan Panyod, Po-Yu Liu, Chieh-Chang Chen, Hsien-Li Kao in Microbiome (2020)

  10. Article

    Open Access

    Impact of Liver Cirrhosis on Incidence of Dialysis Among Patients with Type 2 Diabetes

    Renal injury is a common complication of liver cirrhosis and type 2 diabetes mellitus (T2DM). The aim of this study was to analyze the association between cirrhosis and dialysis in patients with T2DM.

    Yi-**g Sheen, Pei-Tseng Kung, Wayne H.-H. Sheu, Wei-Yin Kuo in Diabetes Therapy (2020)

  11. Article

    Open Access

    A Smartphone-based Diffusometric Immunoassay for Detecting C-Reactive Protein

    In this study, we developed a portable smartphone-based diffusometry for analyzing the C-reactive protein (CRP) concentration. An optimized fluorescence microscopic add-on system for a smartphone was used to i...

    Chih-Shen Chuang, Chih-Zong Deng, Yi-Fan Fang, Hong-Ren Jiang in Scientific Reports (2019)

  12. Article

    Open Access

    CCL4 is the only predictor for non-responder in GT-1 CHC patients with favorable IL28B genotype when treated with PegIFN/RBV

    Chemokines/cytokines play important roles in the pathogenesis of chronic hepatitis C (CHC). However, their clinical characteristics and implications in treatment responses to pegylated interferon plus ribaviri...

    Chia-Chen Lin, Shih-Huan Su, Wen-Juei Jeng, Chien-Hao Huang in BMC Gastroenterology (2017)

  13. Article

    Open Access

    Memory Regulatory T cells Increase Only In Inflammatory Phase of Chronic Hepatitis B Infection and Related to Galectin-9/Tim-3 interaction

    CD4+Foxp3+ regulatory T cells (Tregs) are the main immune suppressors with subpopulation of inflamed-tissue related memory Tregs (mTregs) and non-related resting Treg (rTregs). Previously, Treg was proposed to be...

    Ching-Chih Hu, Wen-Juei Jeng, Yi-Cheng Chen, Jian-He Fang in Scientific Reports (2017)

  14. Article

    Open Access

    A clinicopathological analysis of 153 acral melanomas and the relevance of mechanical stress

    The pathogenesis of melanomas emerging in plantar surfaces remains unclear; however, mechanical stress has been reported to increase the formation of melanomas. In this study, we conducted a multicenter retros...

    Yi-Shuan Sheen, Yi-Hua Liao, Ming-Hsien Lin, Jau-Shiuh Chen in Scientific Reports (2017)

  15. Article

    Open Access

    Increased EMR2 expression on neutrophils correlates with disease severity and predicts overall mortality in cirrhotic patients

    Patients with liver cirrhosis are susceptible to infections with high short-term mortalities. One CD97-related EGF-TM7 molecule, EMR2 (EGF-like molecule containing mucin-like hormone receptor 2), had been show...

    Chien-Hao Huang, Wen-Juei Jeng, Yu-Pin Ho, Wei- Teng, Yi-Chung Hsieh in Scientific Reports (2016)

  16. Article

    Open Access

    7th drug hypersensitivity meeting: part one

    Oral Abstracts

    Daniel F. Carr, Wen-Hung Chung, Rosalind E. Jenkiins in Clinical and Translational Allergy (2016)

  17. No Access

    Article

    TIRF-enhanced nanobeads’ Brownian diffusion measurements for detecting CRP in human serum

    This paper reports the in situ detection of C-reactive protein (CRP) and antibody-coated nanobead interaction by measuring the variation of the Brownian diffusion of the nanobeads. The measurements are carried...

    Yu-Jui Fan, Horn-Jiunn Sheen, Zheng-Yu Chen, Yi-Hsing Liu in Microfluidics and Nanofluidics (2015)

  18. No Access

    Article

    Photoactivated Metal-Oxide Gas Sensing Nanomesh by Using Nanosphere Lithography

    A photoactivated ZnO nanomesh with precisely controlled dimensions and geometries is fabricated by using nanosphere lithography process. The nanomesh structures effectively increase the surface-to-volume ratio...

    Yu-Hsuan Ho, Tsu-Hung Lin, Yi-Wen Chen, Wei-Cheng Tian in MRS Online Proceedings Library (2014)

  19. Article

    Open Access

    AGROBEST: an efficient Agrobacterium-mediated transient expression method for versatile gene function analyses in Arabidopsis seedlings

    Transient gene expression via Agrobacterium-mediated DNA transfer offers a simple and fast method to analyze transgene functions. Although Arabidopsis is the most-studied model plant with powerful genetic and gen...

    Hung-Yi Wu, Kun-Hsiang Liu, Yi-Chieh Wang, **g-Fen Wu, Wan-Ling Chiu in Plant Methods (2014)

  20. No Access

    Article

    Association between the characteristics of metabolic syndrome and Alzheimer’s disease

    Various epidemiological studies have shown that type 2 diabetes and metabolic syndrome are highly correlated with Alzheimer’s disease (AD). Here, we sought to assess the impact of metabolic syndrome characteri...

    Hui-Ting Yang, Yi-**g Sheen, Chuen-Der Kao, Chin-An Chang in Metabolic Brain Disease (2013)

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