10 Result(s)
within
English
Biomedicine
Cell Biology
Human Genetics
Yi**ang Chen
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Article
Open AccessPhase I study of A166, an antibody‒drug conjugate in advanced HER2-expressing solid tumours
In this phase I study, the safety, pharmacokinetics, and antitumour activity of the HER2-targeted antibody–drug conjugate A166 were evaluated in patients with HER2-expressing advanced solid tumours. Patients w...
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Open AccessAutomated and rapid detection of cancer in suspicious axillary lymph nodes in patients with breast cancer
Preoperative staging of suspicious axillary lymph nodes (ALNs) allows patients to be triaged to ALN dissection or to sentinel lymph node biopsy (SLNB). Ultrasound-guided fine needle aspiration (FNA) and cytolo...
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Replication study and meta-analysis indicate a suggestive association of RUNX3 locus with primary biliary cholangitis
Susceptibility to primary biliary cholangitis (PBC) is in part genetically determined. In our previous PBC genome-wide association study (GWAS) in 1118 Han Chinese PBC and 4036 controls, we noted that multiple...
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Article
Identification and expression analysis of a TLR11 family gene in the sea urchin Strongylocentrotus intermedius
In this study, a homolog of the TLR11 family gene from the sea urchin Strongylocentrotus intermedius (denoted as SiTLR11) was cloned and characterized. The full-length cDNA of SiTLR11 was 2096-bp long, which incl...
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Open AccessNext-generation sequencing of circulating tumor DNA to predict recurrence in triple-negative breast cancer patients with residual disease after neoadjuvant chemotherapy
Next-generation sequencing to detect circulating tumor DNA is a minimally invasive method for tumor genoty** and monitoring therapeutic response. The majority of studies have focused on detecting circulating...
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Congenic map** identifies a novel Idd9 subregion regulating type 1 diabetes in NOD mice
Type 1 diabetes (T1D) results from complex interactions between genetic and environmental factors. The nonobese diabetic (NOD) mouse develops spontaneous T1D and has been used extensively to study the genetic ...
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Combined effect of five single nucleotide polymorphisms related to IL23/Th17 pathway in the risk of psoriasis
Psoriasis is a common immune-mediated inflammatory skin disease with strong genetic components, in which the IL23/Th17 pathway has been implicated. To explore the effective role in psoriasis, we genotyped five...
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Article
A regulatory polymorphism in interferon-γ receptor 1 promoter is associated with the susceptibility to chronic hepatitis B virus infection
The antiviral cascade triggered by interferon-γ (IFN-γ) represents a vital event for eradicating hepatitis B virus (HBV) in experimental animals. IFN-γ signaling is mediated through the ligand binding to IFN-γ...
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Subcongenic analysis of genetic basis for impaired development of invariant NKT cells in NOD mice
Reduced numbers and function of invariant NKT (iNKT) cells partially contribute to type 1 diabetes (T1D) development in NOD mice. Previous linkage analysis identified a genetic locus on chromosome 2 controllin...
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HLA polymorphisms are associated with Helicobacter pylori infected gastric cancer in a high risk population, China
Helicobacter pylori is one of the most common bacterial infections associated with an increased risk of gastric cancer, but its association with host factors, particularly polymorphisms of the immune response gen...
