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Article
Arenobufagin regulates the p62-Keap1-Nrf2 pathway to induce autophagy-dependent ferroptosis in HepG2 cells
Hepatocellular carcinoma (HCC) is the most prevalent type of primary liver cancer, accounting for the overwhelming majority of malignant liver tumors. Therefore, how to effectively prevent and cure HCC has bec...
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Article
Open AccessComparison of different treatment strategies for T3N1-3 stage gastric cancer based on the SEER database
Treatment options for T3N1 stage gastric cancer exhibit regional variation, with optimal approach remaining unclear. We derived our data from the SEER database, using Cox proportional risk regression models fo...
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Article
Wh-Words: Existential or Universal Quantifiers in Child Mandarin?
Wh-words have been analysed as existential quantifiers (Chierchia in Logic in grammar: polarity, free choice, and intervention. Oxford University Press, Oxford, 2013; Fox, in Sauerland U, Stateva P (eds) Presupp....
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Article
Mechanism of Paris polyphylla saponin II inducing autophagic to inhibit angiogenesis of cervical cancer
Paris polyphylla saponin II (PPII) has good biological activity in inhibiting tumor angiogenesis. However, the mechanism of its action is still unclear. This study first observed the inhibitory effect of PPII on ...
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Article
Ferritin-mediated mitochondrial iron homeostasis is essential for the survival of hematopoietic stem cells and leukemic stem cells
Iron metabolism plays a crucial role in cell viability, but its relationship with adult stem cells and cancer stem cells is not fully understood. The ferritin complex, responsible for intracellular iron storag...
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Article
Open AccessIdentification of prognostic signatures in remnant gastric cancer through an interpretable risk model based on machine learning: a multicenter cohort study
The purpose of this study was to develop an individual survival prediction model based on multiple machine learning (ML) algorithms to predict survival probability for remnant gastric cancer (RGC).
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Article
Open AccessHistological analysis of (antral) follicle density in ovarian cortex tissue attached to stripped endometriomas
When resecting endometriomas with the strip** technique, in the majority of cases, a thin line of adjacent ovarian cortex is attached to the endometrioma. In this study, we performed histological analysis to...
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Article
Open AccessConstructing and validating the museum product creativity measurement (MPCM): dimensions for creativity assessment of souvenir products in Chinese urban historical museums
As museums continue to play an increasingly significant role in the preservation, innovation, and dissemination of cultural heritages, the products sold in their souvenir shops have become a vital carrier of c...
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Article
Open AccessCell softness renders cytotoxic T lymphocytes and T leukemic cells resistant to perforin-mediated killing
Mechanical force contributes to perforin pore formation at immune synapses, thus facilitating the cytotoxic T lymphocytes (CTL)-mediated killing of tumor cells in a unidirectional fashion. How such mechanical ...
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Article
Open AccessTransperitoneal vs retroperitoneal laparoscopic radical nephrectomy: a double-arm, parallel-group randomized clinical trial
To compare the outcomes of patients undergoing Retroperitoneal laparoscopic Radical nephrectomy (RLRN) and Transperitoneal laparoscopic Radical nephrectomy (TLRN).
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Article
Open AccessCorrection: Exploring the association between triglyceride-glucose index and thyroid function
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Article
Open AccessCXCL9 may serve as a potential biomarker for primary Sjögren’s syndrome with extra-glandular manifestations
Primary Sjögren's syndrome (pSS) is an autoimmune condition that causes harm to exocrine glands and also has extra-glandular manifestations (EGM). pSS patients with EGM have a worse prognosis than those with o...
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Chapter and Conference Paper
Research of Seat Vibration Absorption Performance by Vibration Model
The poor vibration absorption performance and large amplitude of seat during driving are common in vehicle development and market compliant. This paper establishes forced vibration and free vibration models of...
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Chapter and Conference Paper
Study on Dynamic Modeling and Vibration Noise Suppression Method of AUV
This paper focuses on the key technical problems of the autonomous underwater vehicle (AUV) vibration and noise reduction. The dynamic model of AUV with propeller-shaft-motor by the second Lagrange method is e...
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Article
Deformation characteristics and layout optimization of roadway in complex jointed rock mass: a case study based on discrete element method
Complex jointed rock masses are common in nature. When a roadway is located in complex jointed rock mass, numerous joints can weaken the strength of surrounding rock, resulting in large deformation of the road...
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Article
Open AccessExploring the association between triglyceride-glucose index and thyroid function
Thyroid dysfunction is associated with abnormal glucose-insulin homeostasis, and the triglyceride-glucose (TyG) index has been recommended as a convenient surrogate of insulin resistance (IR). This study aimed...
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Article
Open AccessComparison of 3 and 4 cycles of neoadjuvant gemcitabine and cisplatin for muscle-invasive bladder cancer: a systematic review and meta-analysis
In muscle-invasive bladder cancer (MIBC), neoadjuvant chemotherapy (NAC) combined with radical cystectomy (RC) is critical in reducing disease recurrence, with GC (gemcitabine and cisplatin) being one of the m...
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Article
Circ_0001715 Functions as a miR-1249-3p Sponge to Accelerate the Progression of Non-small Cell Lung Cancer via Upregulating the Level of FGF5
Circular RNAs (circRNAs) have been widely involved in the malignant development of human cancers. Circ_0001715 was aberrantly upregulated in non-small cell lung cancer (NSCLC). However, circ_0001715 function h...
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Article
LncRNA NEAT1 antagonizes the inhibition of melanoma proliferation, migration, invasion and EMT by Polyphyllin B
Polyphyllin B (PPB) is a compound with anti-tumor effects. Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long-stranded noncoding RNA that induces epithelial-mesenchymal transition (EMT) of tumor cells...
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Article
Synergistic Protective Effect of Interactions of Quercetin with Lycopene Against Ochratoxin A-Induced Ulcerative Colitis
Ulcerative colitis is a type of inflammatory bowel disease responsible for the inflammation of the innermost lining of the colon and rectum. The present study’s objective is to determine the potential synergis...
