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Open AccessTranscriptome profiles of Streptomyces clavuligerus strains producing different titers of clavulanic acid
Streptomyces clavuligerus NRRL 3585 is a native producer of clavulanic acid (CA), a clinically used β-lactamase inhibitor, and is widely used as an industrial strain for the production of antibiotics. Selective r...
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Dactylides A−C, three new bioactive 22-membered macrolides produced by Dactylosporangium aurantiacum
Three new 22-membered polyol macrolides, dactylides A−C (1−3), were isolated from Dactylosporangium aurantiacum ATCC 23491 employing repeated chromatographic separations, and their structures were established bas...
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Open AccessWhole-genome sequencing and analysis of Streptomyces strains producing multiple antinematode drugs
Nematodes are parasitic animals that cause over 100 billion US dollars loss in agricultural business. The whole-genomes of two Streptomyces strains, Streptomyces spectabilis KCTC9218T and Streptomyces sp. AN09196...
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Correction to: Dynamic analysis of antidum** using impulse responses: a case between the United States and China
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Article
Dynamic analysis of antidum** using impulse responses: a case between the United States and China
This study empirically investigated the dynamic aspects of antidum**. It focuses on the antidum** measures imposed by the United States on Chinese imports. To capture the dynamic effects, we employ a local...
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Article
Publisher Correction: Complete reconstitution of the diverse pathways of gentamicin B biosynthesis
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Microbial production of O-methylated flavanones from methylated phenylpropanoic acids in engineered Escherichia coli
Methylated flavonoids possess improved bioactivities compared to their unmethylated counterparts. In this study, for the efficient production of O-methylated flavonoids from simple methylated phenylpropanoic acid...
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Article
Improved production of clavulanic acid by reverse engineering and overexpression of the regulatory genes in an industrial Streptomyces clavuligerus strain
Genomic analysis of the clavulanic acid (CA)-high-producing Streptomyces clavuligerus strains, OL13 and OR, developed through random mutagenesis revealed a frameshift mutation in the cas1 gene-encoding clavaminat...
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Author Correction: Complete reconstitution of the diverse pathways of gentamicin B biosynthesis
In the version of this article originally published, reference to another structure of GenB1 was omitted (Dow, G. T., Thoden, J. B., & Holden, H. M. The three-dimensional structure of NeoB: an aminotransferase...
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Article
Open AccessHigh-yield production of multiple O-methylated phenylpropanoids by the engineered Escherichia coli–Streptomyces cocultivation system
O-Methylated phenylpropanoids, which are generally present in small amounts in plants, have improved or distinct biological activities and pharmacological properties as opposed to their unmethylated counterpart.....
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Article
Complete reconstitution of the diverse pathways of gentamicin B biosynthesis
Gentamicin B (GB), a valuable starting material for the preparation of the semisynthetic aminoglycoside antibiotic isepamicin, is produced in trace amounts by the wild-type Micromonospora echinospora. Though the ...
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Article
Recent advances in the discovery and combinatorial biosynthesis of microbial 14-membered macrolides and macrolactones
Macrolides, especially 14-membered macrolides, are a valuable group of antibiotics that originate from various microorganisms. In addition to their antibacterial activity, newly discovered 14-membered macrolid...
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Article
Open AccessStructural and mechanistic characterization of an archaeal-like chaperonin from a thermophilic bacterium
The chaperonins (CPNs) are megadalton sized hollow complexes with two cavities that open and close to encapsulate non-native proteins. CPNs are assigned to two sequence-related groups that have distinct allost...
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Article
An overview of rapamycin: from discovery to future perspectives
Rapamycin is an immunosuppressive metabolite produced from several actinomycete species. Besides its immunosuppressive activity, rapamycin and its analogs have additional therapeutic potentials, including anti...
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Article
Open AccessEngineered biosynthesis of milbemycins in the avermectin high-producing strain Streptomyces avermitilis
Milbemycins, produced from Streptomyces hygroscopicus subsp. aureolacrimosus and Streptomyces bingchenggensis, are 16-membered macrolides that share structural similarity with avermectin produced from Streptomyce...
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Article
Open AccessThe dynamic transcriptional and translational landscape of the model antibiotic producer Streptomyces coelicolor A3(2)
Individual Streptomyces species have the genetic potential to produce a diverse array of natural products of commercial, medical and veterinary interest. However, these products are often not detectable under lab...
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Article
The biosynthetic pathway of FK506 and its engineering: from past achievements to future prospects
FK506, a 23-membered macrolide produced by several Streptomyces species, is an immunosuppressant widely used to prevent the rejection of transplanted organs. In addition, FK506 and its analogs possess numerous pr...
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Article
Self-reported eating speed in relation to non-alcoholic fatty liver disease in adults
Non-alcoholic fatty liver disease (NAFLD), known to be related to insulin resistance, has been the focus of intensive research efforts due to its increasing prevalence and clinical significance. Rapid eating b...
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Characterization of fortimicin aminoglycoside profiles produced from Micromonospora olivasterospora DSM 43868 by high-performance liquid chromatography-electrospray ionization-ion trap-mass spectrometry
In this study, an efficient high-performance liquid chromatography (HPLC)-electrospray ionization (ESI)–ion trap-tandem mass spectrometry (MS/MS) was developed for the identification of the biosynthetic congen...
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Erratum: Reinvigorating natural product combinatorial biosynthesis with synthetic biology
Nat. Chem. Biol. 11, 649–659 (2015); published online 18 August 2015; corrected after print 23 September 2015 In the version of this article initially published, there were four typographical errors in the abs...
