7 Result(s)

Article

Targeted ablation of signal transducer and activator of transduction 1 alleviates inflammation by microglia/macrophages and promotes long-term recovery after ischemic stroke

Brain microglia and macrophages (Mi/MΦ) can shift to a harmful or advantageous phenotype following an ischemic stroke. Identification of key molecules that regulate the transformation of resting Mi/MΦ could ai...

Wenxuan Han, Hongjian Pu, Sicheng Li, Yaan Liu… in Journal of Neuroinflammation (2023)

Article

Microglia-specific deletion of histone deacetylase 3 promotes inflammation resolution, white matter integrity, and functional recovery in a mouse model of traumatic brain injury

Histone deacetylases (HDACs) are believed to exacerbate traumatic brain injury (TBI) based on studies using pan-HDAC inhibitors. However, the HDAC isoform responsible for the detrimental effects and the cell t...

Yongfang Zhao, Hongfeng Mu, Yichen Huang, Sicheng Li… in Journal of Neuroinflammation (2022)

Article

Publisher Correction: Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Yejie Shi, Lili Zhang, Hongjian Pu, Leilei Mao, **aoming Hu… in Nature Communications (2020)

Article

Translational Stroke Research on Blood-Brain Barrier Damage: Challenges, Perspectives, and Goals

Yejie Shi, Rehana K. Leak, Richard F. Keep, Jun Chen in Translational Stroke Research (2016)

Article

Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury

The mechanism and long-term consequences of early blood–brain barrier (BBB) disruption after cerebral ischaemic/reperfusion (I/R) injury are poorly understood. Here we discover that I/R induces subtle BBB leak...

Yejie Shi, Lili Zhang, Hongjian Pu, Leilei Mao, **aoming Hu… in Nature Communications (2016)

Article

CART treatment improves memory and synaptic structure in APP/PS1 mice

Major characteristics of Alzheimer’s disease (AD) include deposits of β-amyloid (Aβ) peptide in the brain, loss of synapses and cognitive dysfunction. Cocaine- and amphetamine-regulated transcript (CART) has r...

Jia-li **, Anthony K.F. Liou, Yejie Shi, Kai-lin Yin, Ling Chen… in Scientific Reports (2015)

Article

Galectin-1-secreting neural stem cells elicit long-term neuroprotection against ischemic brain injury

Galectin-1 (gal-1), a special lectin with high affinity to β-galactosides, is implicated in protection against ischemic brain injury. The present study investigated transplantation of gal-1-secreting neural st...

Jiayin Wang, **chao **a, Feng Zhang, Yejie Shi, Yun Wu, Hongjian Pu… in Scientific Reports (2015)