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Flexible BNOH@ polyurethane composites with high in-plane thermal conductivity for efficient thermal management
Develo** flexible thermal management materials is quite urgent for emerging flexible electronics and wearable devices. Here, a novel strategy is used to prepare hydroxyl-functionalized boron nitride@polyuret...
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Retraction Note: Solvent-Free Cyanosilylation of Aldehydes and Anti-cervical Cancer Activity of a Highly Porous Zinc-MOF
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A prospective multi-center randomized comparative trial evaluating outcomes of transrectal ultrasound (TRUS)-guided 12-core systematic biopsy, mpMRI-targeted 12-core biopsy, and artificial intelligence ultrasound of prostate (AIUSP) 6-core targeted biopsy for prostate cancer diagnosis
Artificial intelligence ultrasound of prostate (AIUSP)-targeted biopsy has been used for prostate cancer (PCa) diagnosis. The objective of this prospective multi-center head-to-head clinical randomized compara...
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Open AccessComparative proteomic analysis of children FSGS FFPE tissues
In children, focal segmental glomerulosclerosis (FSGS) is the main cause of steroid resistant nephrotic syndrome (SRNS). To identify specific candidates and the mechanism of steroid resistance, we examined the...
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Open AccessPhenotypic spectrum and genetics of PAX2-related disorder in the Chinese cohort
Pathogenic variants of PAX2 cause autosomal-dominant PAX2-related disorder, which includes variable phenotypes ranging from renal coloboma syndrome (RCS), congenital anomalies of the kidney and urinary tract (CAK...
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Open AccessAn accessible insight into genetic findings for transplantation recipients with suspected genetic kidney disease
Determining the etiology of end-stage renal disease (ESRD) constitutes a great challenge in the context of renal transplantation. Evidence is lacking on the genetic findings for adult renal transplant recipien...
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Open AccessGenetic Architecture of Childhood Kidney and Urological Diseases in China
Kidney disease is manifested in a wide variety of phenotypes, many of which have an important hereditary component. To delineate the genotypic and phenotypic spectrum of pediatric nephropathy, a multicenter re...
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RETRACTED ARTICLE: Solvent-Free Cyanosilylation of Aldehydes and Anti-cervical Cancer Activity of a Highly Porous Zinc-MOF
A new three-dimensional (3D) zinc(II) metal–organic framework (MOF) {[Zn2(abtc)(H2O)3](DMA)}n bearing the rigid organic ligand 3,3′,5,5′-azobenzene-tetracarboxylic acid (H4abtc) were prepared by reaction of zinc(...
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Article
Late Mesozoic Tectonic Evolution of Southwestern Fujian Province, South China: Constraints from Magnetic Fabric, Zircon U-Pb Geochronology and Structural Deformation
A combined study of magnetic fabrics, zircon U-Pb geochronology and structural deformation was carried out for Late Paleozoic sedimentary and Mesozoic magmatic rocks in the southwestern Fujian rift basin, Sout...
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Article
Selenium Speciation in Rice Samples by Magnetic Ionic Liquid-Based Up-and-Down-Shaker-Assisted Dispersive Liquid-Liquid Microextraction Coupled to Graphite Furnace Atomic Absorption Spectrometry
A novel and sensitive magnetic ionic liquid-based up-and-down-shaker-assisted dispersive liquid-liquid microextraction (MIL-UDSA-DLLME) was developed for the graphite furnace atomic absorption spectrometric me...
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Open AccessIntensity interrogation near cutoff resonance for label-free cellular profiling
We report a method enabling intensity-based readout for label-free cellular assays and realize a reader device with the same footprint as a microtiter plate. For unambiguous resonance intensity measurements in...
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The effects of α-zearalanol on the proliferation of bone-marrow-derived mesenchymal stem cells and their differentiation into osteoblasts
The aim of this study was to explore the effects of α-zearalanol (α-ZAL) on the proliferation of mouse bone-marrow-derived mesenchymal stem cells (BMSCs) and their differentiation into osteoblasts. Six- to eig...
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Corning Incorporated: Designing a New Future with Glass and Optics
Corning Incorporated is a world leader in glass and ceramic products, and has been innovating in these materials since 1851. The company sells component-level technical products that are integrated into system...
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Label-Free Cell Phenotypic Identification of d-Luciferin as an Agonist for GPR35
d-Luciferin (also known as beetle or firefly luciferin) is one of the most widely used bioluminescent reporters for monitoring in vitro or in vivo luciferase activity. The identification of several natural phen....
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Label-Free Cell Phenotypic Identification of Active Compounds in Traditional Chinese Medicines
Traditional Chinese medicines (TCMs) have been used in clinic for thousands of years. These TCMs display reliable therapeutic efficacy and are important resources for drug discovery. Elucidating mechanisms of ...
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Protocol
Label-Free Cell Phenotypic Profiling and Screening: Techniques, Experimental Design, and Data Assessment
Label-free biosensors enable novel cell phenotypic assays for drug discovery by providing a holistic view of drug action in native cells. The label-free cellular profiles of drug molecules permit the comprehen...
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Open AccessLabel-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel
Current technologies for studying ion channels are fundamentally limited because of their inability to functionally link ion channel activity to cellular pathways. Herein, we report the use of label-free cell ...
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Open AccessDivergent Label-free Cell Phenotypic Pharmacology of Ligands at the Overexpressed β2-Adrenergic Receptors
We present subclone sensitive cell phenotypic pharmacology of ligands at the β2-adrenergic receptor (β2-AR) stably expressed in HEK-293 cells. The parental cell line was transfected with green fluorescent protein...
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Open AccessLabel-free integrative pharmacology on-target of opioid ligands at the opioid receptor family
In vitro pharmacology of ligands is typically assessed using a variety of molecular assays based on predetermined molecular events in living cells. Many ligands including opioid ligands pose the ability to bind ...
