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  1. No Access

    Article

    5-Aminolevulinic acid regulates the grain morphology, carbohydrate and hormone contents, increasing grain yield of maize in field land

    5-aminolaevulinic acid (ALA), being a plant growth promoter, effectively improves plant growth and development. However, relevant reports are deficient on how ALA regulates the maize grain yield. In this study...

    Lei Xu, Lidi Yuan, Ye Che, Fuzhong Tan, Di Wang, Zhigang Zhang… in Plant Growth Regulation (2024)

  2. No Access

    Article

    Novel Multiplexed High Throughput Screening of Selective Inhibitors for Drug-Metabolizing Enzymes Using Human Hepatocytes

    Selective chemical inhibitors are critical for reaction phenoty** to identify drug-metabolizing enzymes that are involved in the elimination of drug candidates. Although relatively selective inhibitors are a...

    Jianhua Liu, Daria Vernikovskaya, Gary Bora, Anthony Carlo… in The AAPS Journal (2024)

  3. No Access

    Article

    Characterization of CYP3A5 Selective Inhibitors for Reaction Phenoty** of Drug Candidates

    CYP3A is one of the most important classes of enzymes and is involved in the metabolism of over 70% drugs. While several selective CYP3A4 inhibitors have been identified, the search for a selective CYP3A5 inhi...

    Jie Chen, Lloyd Wei Tat Tang, Samantha Jordan, Makayla Harrison… in The AAPS Journal (2024)

  4. Article

    BNT162b vaccines protect rhesus macaques from SARS-CoV-2

    A safe and effective vaccine against COVID-19 is urgently needed in quantities that are sufficient to immunize large populations. Here we report the preclinical development of two vaccine candidates (BNT162b1 ...

    Annette B. Vogel, Isis Kanevsky, Ye Che, Kena A. Swanson, Alexander Muik… in Nature (2021)

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  5. No Access

    Article

    Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes

    Heterobifunctional chimeric degraders are a class of ligands that recruit target proteins to E3 ubiquitin ligases to drive compound-dependent protein degradation. Advancing from initial chemical tools, protein...

    James Schiemer, Reto Horst, Yilin Meng, Justin I. Montgomery… in Nature Chemical Biology (2021)

  6. Article

    Open Access

    Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20

    Chemokines are important protein-signaling molecules that regulate various immune responses by activating chemokine receptors which belong to the G protein-coupled receptor (GPCR) superfamily. Despite the subs...

    David Jonathan Wasilko, Zachary Lee Johnson, Mark Ammirati, Ye Che… in Nature Communications (2020)

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  7. No Access

    Protocol

    Design of Cyclic Peptides as Protein Recognition Motifs

    Protein–protein interactions are ubiquitous, essential to almost all known biological processes, and offer attractive opportunities for therapeutic intervention. Linear peptide drugs, however, can be applied t...

    Ye Che in Cyclic Peptide Design (2019)

  8. No Access

    Article

    Detection of conformation types of cyclosporin retaining intramolecular hydrogen bonds by mass spectrometry

    Cyclosporin is a family of neutral cyclic undecapeptides widely used for the prevention of organ transplant rejection and controlling viral infection. The equilibrium of conformations assumed by cyclosporin A ...

    Suk-Joon Hyung, **dong Feng, Ye Che… in Analytical and Bioanalytical Chemistry (2014)

  9. No Access

    Protocol

    Chemogenomics with Protein Secondary-Structure Mimetics

    During molecular recognition of proteins in biological systems, helices, reverse turns, and β-sheets are dominant motifs. Often there are therapeutic reasons for blocking such recognition sites, and significan...

    Garland R. Marshall, Daniel J. Kuster, Ye Che in Chemogenomics (2009)

  10. No Access

    Article

    Development of small molecules designed to modulate protein–protein interactions

    Protein–protein interactions are ubiquitous, essential to almost all known biological processes, and offer attractive opportunities for therapeutic intervention. Develo** small molecules that modulate protei...

    Ye Che, Bernard R. Brooks… in Journal of Computer-Aided Molecular Design (2006)