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  1. Article

    Open Access

    A covalent BTK ternary complex compatible with targeted protein degradation

    Targeted protein degradation using heterobifunctional chimeras holds the potential to expand target space and grow the druggable proteome. Most acutely, this provides an opportunity to target proteins that lac...

    James Schiemer, Andrew Maxwell, Reto Horst, Shen** Liu… in Nature Communications (2023)

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  2. No Access

    Article

    Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes

    Heterobifunctional chimeric degraders are a class of ligands that recruit target proteins to E3 ubiquitin ligases to drive compound-dependent protein degradation. Advancing from initial chemical tools, protein...

    James Schiemer, Reto Horst, Yilin Meng, Justin I. Montgomery… in Nature Chemical Biology (2021)