59 Result(s)

Article

KRAS G12 mutations as adverse prognostic factors in KMT2A-rearranged acute myeloid leukemia

Shinju Iyoda, Kenichi Yoshida, Kota Shoji, Nana Ito, Miu Tanaka… in Leukemia (2024)

Article

Sustained remission after cord blood transplantation for breast cancer with lung metastases and myelodysplastic syndrome

Allogenic hematopoietic stem cell transplantation (allo-HSCT) is not a standard therapy for solid cancer because of its high toxicity and insufficient evidence levels. However, the potential graft-versus-solid...

Naokazu Nakamura, Nao Yamamoto, Tadakazu Kondo… in International Journal of Hematology (2024)

Article

First report of familial mixed phenotype acute leukemia: shared clinical characteristics, Philadelphia translocation, and germline variants

While our understanding of the molecular basis of mixed phenotype acute leukemia (MPAL) has progressed over the decades, our knowledge is limited and the prognosis remains poor. Investigating cases of familial...

Yuka Shiozawa, Shinya Fujita, Yasuhito Nannya… in International Journal of Hematology (2024)

Article

Donor NKG2D rs1049174 polymorphism predicts hematopoietic recovery and event-free survival after single-unit cord blood transplantation in adults

Takaaki Konuma, Megumi Hamatani-Asakura, Maki Monna-Oiwa… in Bone Marrow Transplantation (2024)

Article

Unrelated hematopoietic stem cell transplantation for familial platelet disorder/acute myeloid leukemia with germline RUNX1 mutations

Germline mutations in RUNX1 result in rare autosomal-dominant familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML). As genetic analysis is becoming increasingly prevalent, the diagno...

Kazunori Toratani, Mizuki Watanabe, Junya Kanda… in International Journal of Hematology (2023)

Article

Successful azacitidine therapy for myelodysplastic syndrome associated with VEXAS syndrome

VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is caused by UBA1 somatic mutations and is characterized by late-onset systemic autoimmune inflammation and blood abnormalities such as cy...

Asami Kataoka, Chisaki Mizumoto, Junya Kanda… in International Journal of Hematology (2023)

Article

Thyrotoxicosis after unrelated cord blood transplantation for adults

Takaaki Konuma, Akira Tomonari, Jun Ooi, Hitomi Nagayama… in Annals of Hematology (2023)

Article

Genetic deletion and pharmacologic inhibition of E3 ubiquitin ligase HOIP impairs the propagation of myeloid leukemia

We investigated the role of Hoip, a catalytic subunit of linear ubiquitin chain assembly complex (LUBAC), in adult hematopoiesis and myeloid leukemia by using both conditional deletion of Hoip and small-molecule ...

Koji Jimbo, Ayuna Hattori, Shuhei Koide, Takahiro Ito, Katsuhiro Sasaki… in Leukemia (2023)

Article

Prognostic impact of switching from cyclosporine to corticosteroids early after single cord blood transplantation

Kosuke Takano, Takaaki Konuma, Maki Monna-Oiwa, Masamichi Isobe… in Annals of Hematology (2022)

Article

Immunoglobulin superfamily member 8 maintains myeloid leukemia stem cells through inhibition of β-catenin degradation

The identification of characteristic differences between cancer stem cells and their normal counterparts remains a key challenge for cancer treatment. Here, we investigated the role of immunoglobulin superfami...

Koji Jimbo, Yaeko Nakajima-Takagi, Takahiro Ito, Shuhei Koide, Yasuhito Nannya… in Leukemia (2022)

Article

Identification of an asymptomatic Shwachman–Bodian–Diamond syndrome mutation in a patient with acute myeloid leukemia

Shwachman–Diamond syndrome (SDS) is an autosomal recessive inherited disorder characterized by bone marrow failure, exocrine pancreatic dysfunction, and skeletal abnormalities. SDS is typically caused by a pat...

Sho Shibata, Shojiro Inano, Mizuki Watanabe… in International Journal of Hematology (2022)

Article

Germline RUNX1 translocation in familial platelet disorder with propensity to myeloid malignancies

Masatoshi Sakurai, Yasuhito Nannya, Rie Yamazaki, Kentaro Yamaguchi… in Annals of Hematology (2022)

Article

Hematological effects on peri-transplant use of linezolid in adults undergoing single-unit cord blood transplantation

Takeo Yasu, Takaaki Konuma, Maki Oiwa-Monna, Satoshi Takahashi… in Annals of Hematology (2021)

Article

Paroxysmal nocturnal hemoglobinuria complicated with essential thrombocythemia harboring concomitant PIGA, CALR, and ASXL1 mutations

Haruya Okamoto, Nobuhiko Uoshima, Yuri Kamitsuji, Eri Kawata… in Annals of Hematology (2021)

Article

Co-mutation pattern, clonal hierarchy, and clone size concur to determine disease phenotype of SRSF2^P95-mutated neoplasms

Somatic mutations in splicing factor genes frequently occur in myeloid neoplasms. While SF3B1 mutations are associated with myelodysplastic syndromes (MDS) with ring sideroblasts, SRSF2^P95 mutations are found in ...

Gabriele Todisco, Maria Creignou, Anna Gallì, Paola Guglielmelli, Elisa Rumi… in Leukemia (2021)